Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IHMT-PI3Kδ-372 is a selective inhibitor of PI3Kδ with an IC50 of 14 nM and can be used in studies about chronic obstructive pulmonary disease.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 10,500 | |||
5 mg | 在庫あり | ¥ 26,000 | |||
10 mg | 在庫あり | ¥ 41,000 | |||
25 mg | 在庫あり | ¥ 67,500 | |||
50 mg | 在庫あり | ¥ 100,000 | |||
100 mg | 在庫あり | ¥ 136,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 27,000 |
説明 | IHMT-PI3Kδ-372 is a selective inhibitor of PI3Kδ with an IC50 of 14 nM and can be used in studies about chronic obstructive pulmonary disease. |
ターゲット&IC50 | CYP2C9:2.7 μM (IC50), PI3Kδ:14 nM (IC50) |
In vitro | In Raji cells, IHMT-PI3Kδ-372 (0.03-3 μM) inhibits PI3Kδ-mediated AKT T308 phosphorylation (EC50 = 67 nM).IHMT-PI3Kδ-372 moderately inhibits CYP2C9 (IC50 = 2.7 μM) and no apparently inhibits CYP1A2, CYP2B6, CYP2C19, and CYP3A4 (IC50s > 10 μM)[1]. |
In vivo | IHMT-PI3Kδ-372 (1-5 mg/kg; inhalation) improves lung function and reduced the inflammatory patterns characteristic of COPD with better forced expiratory volume in FEV1, FVC, and PEF. IHMT-PI3Kδ-372 dose-dependently decreases the inflammatory cell and reduces the abnormally high level of leukocytes including the alveolar macrophages, neutrophils, and lymphocytes. In rats, IHMT-PI3Kδ-372 (5 mg/kg; inhalation) displays a half-life of 2.3 h, low exposure of 66 ng/mL, and high clearance of 348.5 mL/min/kg in plasma and high exposure of 5599 ng/g (6 h after inhalation) in lung tissue[1]. |
別名 | IHMT-PI3Kδ-372 |
分子量 | 503.5 |
分子式 | C26H23F2N7O2 |
CAS No. | 2429889-62-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 37.8 mg/mL (75.1 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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IHMT-PI3Kδ-372 2429889-62-1 PI3K/Akt/mTOR signaling PI3K IHMT-PI3Kdelta-372 IHMTPI3Kδ372 IHMT-PI-3Kδ-372 IHMT PI3Kδ 372 Inhibitor inhibitor inhibit