store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JAK-IN-21 is a selective and potent JAK inhibitor that inhibits JAK1, JAK2, J2V617F and TYK2 with IC50 values of 1.73, 2.04, 109 and 62.9 nM, respectively.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 49,500 |
2 mg | 在庫あり | ¥ 73,000 |
5 mg | 在庫あり | ¥ 123,500 |
10 mg | 在庫あり | ¥ 189,000 |
25 mg | 在庫あり | ¥ 363,000 |
50 mg | 在庫あり | ¥ 454,500 |
100 mg | 在庫あり | ¥ 574,000 |
説明 | JAK-IN-21 is a selective and potent JAK inhibitor that inhibits JAK1, JAK2, J2V617F and TYK2 with IC50 values of 1.73, 2.04, 109 and 62.9 nM, respectively. |
ターゲット&IC50 | JAK1:1.73 nM, TYK2:62.9 nM, JAK2:2.04 nM, JAK2 (V617F):109 nM |
In vitro | JAK-IN-21 (Example 4) lacks inhibitory effects on CYPs and demonstrates favorable stability in liver microsomes.[1] |
In vivo | JAK-IN-21 (Example 4) (10 mg/kg; Oral gavage; SD rats) exhibits limited bioavailability with a value of 1.9%.[1] |
分子量 | 372.38 |
分子式 | C19H16N8O |
CAS No. | 2445499-20-5 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
JAK-IN-21 2445499-20-5 Angiogenesis Chromatin/Epigenetic JAK/STAT signaling Stem Cells Tyrosine Kinase/Adaptors Tyrosine Kinases JAK Inhibitor inhibitor inhibit