Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor. The solute carrier (SLC) monocarboxylate transporter 1 (MCT1; SLC16A1) represents a promising target for the treatment of cancer. MCT1-IN-3 (compound 24) showed the highest MCT1 transport inhibition with an IC50 value of 81.0 Nm. MCT1-IN-3 has also significant inhibitivity against the multidrug transporter ABCB1.
説明 | MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor. The solute carrier (SLC) monocarboxylate transporter 1 (MCT1; SLC16A1) represents a promising target for the treatment of cancer. MCT1-IN-3 (compound 24) showed the highest MCT1 transport inhibition with an IC50 value of 81.0 Nm. MCT1-IN-3 has also significant inhibitivity against the multidrug transporter ABCB1. |
ターゲット&IC50 | MCT1:81nM |
In vitro | MCT1-IN-3 has great antiproliferative activities against the MCT1-expressing cancer cell lines A-549 and MCF-7 with GI50 values of 20 μM and 15.1 μM, respectively. Treatment with MCT1-IN-3 5μM for 24 h significantly leads to cancer cell cycle arrest as well as apoptosis, which has also significant inhibitory power against the multidrug transporter ABCB1 and shows to reverse ABCB1-mediated multidrug resistance (MDR)[1]. |
分子量 | 389.4 |
分子式 | C22H19N3O4 |
CAS No. | 2878360-80-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 22.5 mg/mL (57.78 mM)
You can also refer to dose conversion for different animals. 詳細
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MCT1-IN-3 2878360-80-4 Membrane transporter/Ion channel Monocarboxylate transporter MCT1IN3 Inhibitor inhibitor inhibit