Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that effectively impedes the activity of TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2. It exhibits antiproliferative effects on MCF7, HCT116, and EKVX cancer cell lines with IC50s of 3.36 μM, 1.40 μM, and 3.49 μM, respectively. Furthermore, Multi-kinase-IN-6 induces cell cycle arrest at the G1/S and G1 phases in MCF7 and HCT116 cells, respectively, and triggers apoptosis effectively [1].
説明 | Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that effectively impedes the activity of TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2. It exhibits antiproliferative effects on MCF7, HCT116, and EKVX cancer cell lines with IC50s of 3.36 μM, 1.40 μM, and 3.49 μM, respectively. Furthermore, Multi-kinase-IN-6 induces cell cycle arrest at the G1/S and G1 phases in MCF7 and HCT116 cells, respectively, and triggers apoptosis effectively [1]. |
In vitro | MK2-IN-5 at concentrations of 5-10 μM for 2 hours inhibits the expression of connective tissue growth factor and type I collagen induced by TGF-b1 in human scar keloid fibroblasts [3]. |
In vivo | MK2-IN-5 (2 mg/kg, intraperitoneal injection, single dose) reduces the phosphorylation of HSP25 in ventilator-induced lung injury models [2]. |
動物実験 | s |
分子量 | N/A |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Multi-kinase-IN-6 Tyrosine Kinase/Adaptors Trk receptor Inhibitor inhibitor inhibit