Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NRX-103094 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP, which enhances the affinity of pSer33/Ser37 β-catenin for β-TrCP with an EC50 of 62 nM and a Kd of 0.6 nM.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 15,500 | |||
5 mg | 在庫あり | ¥ 37,500 | |||
10 mg | 在庫あり | ¥ 66,500 | |||
25 mg | 在庫あり | ¥ 133,000 | |||
50 mg | 在庫あり | ¥ 209,500 | |||
100 mg | 在庫あり | ¥ 314,500 |
説明 | NRX-103094 is a potent enhancer of the interaction of β-catenin with the homologous E3 ligase SCFβ-TrCP, which enhances the affinity of pSer33/Ser37 β-catenin for β-TrCP with an EC50 of 62 nM and a Kd of 0.6 nM. |
ターゲット&IC50 | β-catenin-β-TrCP:0.6 nM(Kd), β-catenin-β-TrCP:62 nM(EC50) |
In vitro |
RX-103094 demonstrates high potency against the pSer33/Ser37 β-catenin peptide with an EC50 of 457 nM. At 250 nM, NRX-103094 enhances the ubiquitylation of the pSer33/S37A β-catenin peptide to levels surpassing those of the wild-type pSer33/pSer37.[1] NRX-103094 significantly enhances the binding affinity of the S33E/S37A phosphomimetic peptide for β-TrCP, reducing it from >5 μM in the absence of the compound to 22 nM in the presence of 40 μM NRX-103094. In the presence of 20 μM NRX-103094, we observe robust, time-dependent ubiquitylation of the S33E/S37A β-catenin peptide. Similarly, when 20 μM NRX-103094 is present, the full-length S33E/S37A β-catenin protein undergoes strong ubiquitylation, with ubiquitylation levels approaching those of the WT full-length β-catenin protein.[1] |
別名 | NRX103094, NRX 103094 |
分子量 | 503.28 |
分子式 | C20H11Cl2F3N2O4S |
CAS No. | 2763260-36-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL (79.48 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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NRX-103094 2763260-36-0 Cytoskeletal Signaling Stem Cells Wnt/beta-catenin NRX103094 NRX 103094 Inhibitor inhibitor inhibit