Powder: -20°C for 3 years | In solvent: -80°C for 1 year
OT-551 HCl is an NF-Κb inhibitor, a disubstituted hydroxylamine with antioxidant properties can be used for the treatment of cataracts and age-related macular degeneration and geographic atrophy (GA).
説明 | OT-551 HCl is an NF-Κb inhibitor, a disubstituted hydroxylamine with antioxidant properties can be used for the treatment of cataracts and age-related macular degeneration and geographic atrophy (GA). |
In vivo | OT-551 HCl (intraperitoneally injected; rats; approximately 30 min prior to a 6 h exposure to 2700 lux white fluorescent light) significantly reduced the number of RPE cell nuclei in light-exposed eyes from water-treated animals. RPE damage index was significantly lower in the animals treated with any dose of OT-551 HCl compared to water-treated animals both in the inferior and superior hemispheres. Systemic administration of OT-551 HCl provides RPE cell protection against acute light damage.[1] |
別名 | OT-551 HCl(627085-11-4 Free base) |
分子量 | 474.55 |
分子式 | C27H30N4O4 |
CAS No. | 627085-15-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.6 mg/mL (12.96 mM)
You can also refer to dose conversion for different animals. 詳細
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OT-551 HCl 627085-15-8 NF-Κb NF-κB OT-551 HCl(627085-11-4 Free base) 627085-11-4 627085-11-4 Free base Inhibitor inhibitor inhibit