store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PAF (C16) is a potent MAPK and MEK/ERK activator that induces increased vascular permeability. PAF (C16) (PAF (C16)) is a platelet-activating factor, a phospholipid-derived mediator and a ligand for PAF G protein-coupled receptor (PAFR). PAF (C16) has shown anti-apoptotic and anti-inflammatory activity in vitro, inhibiting Caspase-dependent apoptosis by interacting with its receptor (PAF-R) to perform cell signaling.
説明 | PAF (C16) is a potent MAPK and MEK/ERK activator that induces increased vascular permeability. PAF (C16) (PAF (C16)) is a platelet-activating factor, a phospholipid-derived mediator and a ligand for PAF G protein-coupled receptor (PAFR). PAF (C16) has shown anti-apoptotic and anti-inflammatory activity in vitro, inhibiting Caspase-dependent apoptosis by interacting with its receptor (PAF-R) to perform cell signaling. |
In vitro |
In PAFR+/+ cultures, C16-PAF (PAF (C16); 0.5-1.5 μM; for 24 hours) does not elicit significant concentration-dependent neuronal loss, whereas it does induce significant concentration-dependent neuronal loss in PAFR?/? cultures. Specifically, C16-PAF (1 μM) induces neuronal death in PAFR?/? cells infected with EGFP alone[1].In PAFR neurons, C16-PAF (1 μM; for 24 hours) activates caspase 7 but not caspase 3[1]. Synthesized by two distinct pathways, the remodeling pathway and the de novo synthesis pathway, C16-PAF acts by binding to a unique G-protein-coupled seven-transmembrane receptor[2][3]. Furthermore, C16-PAF (1-25 μg/ml; 6, 12, 24 h) exhibits time-dependent inhibition of M. smegmatis and M. bovis BCG growth[3]. |
別名 | C16-PAF |
分子量 | 523.68 |
分子式 | C26H54NO7P |
CAS No. | 74389-68-7 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 30 mg/mL (57.29 mM), Sonication is recommended.
DMSO: 40 mg/mL (76.38 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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PAF (C16) 74389-68-7 MAPK Metabolism ERK MEK Endogenous Metabolite C16-PAF C16 PAF C-16 C 16 Inhibitor inhibitor inhibit