Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PI5P4Ks-IN-2 is an inhibitor of the phosphatidylinositol 5-phosphate 4-kinase PI5P4Kγ. Targeting the PI5P4K isoforms, PI5P4Ks-IN-2 inhibited PI5P4Kα, PI5P4Kβ, PI5P4Kγ, and PI5P4Kγ+, with IC50 values of <4.3, <4.6, 6.2, and 0.32, respectively.
説明 | PI5P4Ks-IN-2 is an inhibitor of the phosphatidylinositol 5-phosphate 4-kinase PI5P4Kγ. Targeting the PI5P4K isoforms, PI5P4Ks-IN-2 inhibited PI5P4Kα, PI5P4Kβ, PI5P4Kγ, and PI5P4Kγ+, with IC50 values of <4.3, <4.6, 6.2, and 0.32, respectively. |
ターゲット&IC50 | PI5P4Kα:<4.3(pIC50), PI5P4Kβ:<4.6(pIC50), PI5P4Kγ:6.2(pIC50), PI5P4Kγ+:0.32(pIC50), PI5P4Kγ (WT):68 nM(Ki), PI5P4Kβ:>30 μM(Ki) |
In vitro | PI5P4Ks-IN-2 (10 μM) showed selectivity towards a group of 140 protein kinases and 15 lipid kinases, binding to PI5P4Kγ-WT (Ki=68 nM) or PI5P4Kβ (Ki >30,000 nM).[1] |
In vivo | PI5P4Ks-IN-2 (10 μM) showed selectivity towards a group of 140 protein kinases and 15 lipid kinases, binding to PI5P4Kγ-WT (Ki=68 nM) or PI5P4Kβ (Ki >30,000 nM).[1] |
分子量 | 357.45 |
分子式 | C22H23N5 |
CAS No. | 2766854-03-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (72.08 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PI5P4Ks-IN-2 2766854-03-7 PI3K/Akt/mTOR signaling PI3K PI5P4KsIN2 Inhibitor inhibitor inhibit