Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RSH-7 is a potent dual inhibitor of BTK and FLT3, with IC50s of 47 and 12 nM, respectively.RSH-7 has antiproliferative and antitumor activities, inducing apoptosis and inhibiting BTK and FLT3 signaling.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 22,500 | |||
5 mg | 在庫あり | ¥ 60,500 | |||
10 mg | 在庫あり | ¥ 98,500 | |||
25 mg | 在庫あり | ¥ 186,500 | |||
50 mg | 在庫あり | ¥ 271,000 | |||
100 mg | 在庫あり | ¥ 372,000 | |||
500 mg | 在庫あり | ¥ 741,500 |
説明 | RSH-7 is a potent dual inhibitor of BTK and FLT3, with IC50s of 47 and 12 nM, respectively.RSH-7 has antiproliferative and antitumor activities, inducing apoptosis and inhibiting BTK and FLT3 signaling. |
ターゲット&IC50 | BTK:47 nM, FLT3:12 nM |
In vitro |
RSH-7 (1-1000 nM; 72 h) exhibits antiproliferative activities for Jeko-1, MV-4-11, Molt4, and K562 cells with IC50 values of 17 nM, 3 nM, 11 nM, and 930 nM respectively.[1] RSH-7 (1-1000 nM; 72 h) dose-dependently reduces the expression of p-BTK (TYR223), p-PLCγ(Tyr1217), p-FLT3 (Tyr589), and p-STAT5 (TYR694).[1] RSH-7 (1-1000 nM; 72 h) dose-dependently triggers apoptosis and upregulates the expression of BAX, p53, and cleaved caspase 3 in Jeko-1 cells.[1] |
In vivo | RSH-7 (25, 50 mg/kg; i.p.; daily for 16 days; Female NOD/SCID mice) suppressed tumor growth in a dose-dependent manner, with tumor growth inhibition (TGI) values of 66.95% and 79.78% at doses of 25 and 50 mg/kg.[1] |
分子量 | 436.49 |
分子式 | C22H25FN8O |
CAS No. | 2764609-97-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 75 mg/mL (171.83 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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RSH-7 2764609-97-2 Angiogenesis Apoptosis Tyrosine Kinase/Adaptors BTK FLT Inhibitor inhibitor inhibit