Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AB21 HCl is a selective antagonist of the σ1 receptor, with Kis of 13 nM for σ1 receptor and 102 nM for σ2 receptor. AB21 HCl is known for its ability to reduce mechanical hypersensitivity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 45,000 | |||
5 mg | 在庫あり | ¥ 99,000 | |||
10 mg | 在庫あり | ¥ 146,000 | |||
25 mg | 在庫あり | ¥ 226,500 | |||
50 mg | 在庫あり | ¥ 312,500 | |||
100 mg | 在庫あり | ¥ 420,000 | |||
500 mg | 在庫あり | ¥ 844,500 |
説明 | AB21 HCl is a selective antagonist of the σ1 receptor, with Kis of 13 nM for σ1 receptor and 102 nM for σ2 receptor. AB21 HCl is known for its ability to reduce mechanical hypersensitivity. |
ターゲット&IC50 | S1R:13 nM (ki), S2R:102 nM(ki) |
In vitro | AB21 HCL measured Ki values of 12 nM and 14 nM in the S1R radioligand binding assay with and without Phenythoin, respectively.[1] |
In vivo | AB21 HCL (20 mg/kg; s.c.; administered 30 minutes before injection of Capsaicin reversed mechanical hypersensitivity in a Phenythoin-induced pain model and showed greater efficacy than BD1063 dihydrochloride higher potency, the dose administered was half that of BD-1063 (40 mg/kg).[1] |
分子量 | 384.2 |
分子式 | C23H29ClN2O |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6.25 mg/mL (16.27 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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AB21 HCl GPCR/G Protein Sigma receptor AB21HCL Inhibitor inhibitor inhibit