Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SCH529074 is a selective activator of p53 (Ki = 1 μM) and can be used in studies about non-small-cell lung carcinoma. SCH529074 restores mutant p53 function and interrupts HDM2-mediated ubiquitination of wild Type p53.
説明 | SCH529074 is a selective activator of p53 (Ki = 1 μM) and can be used in studies about non-small-cell lung carcinoma. SCH529074 restores mutant p53 function and interrupts HDM2-mediated ubiquitination of wild Type p53. |
ターゲット&IC50 | p53 DBD:1-2 μM (Ki) |
In vitro | SCH529074 (2-4 µM) reduces cell viability and decreases to 20-25% in p53 mutant cells including H157, H1975, and H322, and to 68% in the p53 WT cell line A549 at 4 µM. SCH 529074 (2-4 µM) induces NSCLC cells including H157, A549, HCT116, and HCT116 p53-/- arrested at the G0/G1 phase (59%; 72%; 66%; and 57%)[2]. |
In vivo | In female nude mice, 5–7 weeks of age, received subcutaneous inoculation of DLD-1 human colorectal carcinoma cells, SCH529074 (orally; 30 and 50 mg/kg) reduces 79 and 43% of tumor growth with the plasma exposure of 0.26–0.55 μm at 30 mg/kg and 0.39-0.79 μm at 50 mg/kg[1]. |
別名 | SCH 529074 |
分子量 | 563.56 |
分子式 | C31H36Cl2N6 |
CAS No. | 922150-11-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 33 mg/mL
DMF: 33 mg/mL
DMSO: 22.5mg/mL (39.9mM)
You can also refer to dose conversion for different animals. 詳細
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SCH529074 922150-11-6 Apoptosis p53 SCH-529074 SCH 529074 Inhibitor inhibitor inhibit