Powder: -20°C for 3 years | In solvent: -80°C for 1 year
STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM.
説明 | STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM. |
In vitro | STX-0119 (10-50 μM; 24 h) inhibits STAT3 dimerization through a direct interaction with the STAT3 protein and not via the modulation of upstream regulators such as JAK in HEK293 and MDA-MB-468 cells. STX-0119 (10-50 μM; 24 h) reduces the expression of STAT3 target proteins[1]. |
In vivo | STX-0119 (160 mg/kg; oral gavage; daily for 4 days) inhibits SCC-3 tumor growth in mice. The plasma concentration of STX-0119 (160 mg/kg; oral gavage) is maintained at >100 μg/mL (>260 μM), even at 8 h after administration[1]. |
分子量 | 382.37 |
分子式 | C22H14N4O3 |
CAS No. | 851095-32-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (143.84 mM)
You can also refer to dose conversion for different animals. 詳細
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STX-0119 851095-32-4 JAK/STAT signaling Stem Cells STAT STX 0119 STX0119 Inhibitor inhibitor inhibit