Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tanimilast (CHF-6001) is a novel, potent and selective phosphodiesterase 4 inhibitor with an IC 50 value of 0.026 ± 0.006 nM.Tanimilast has potent anti-inflammatory activity and is indicated for topical use in the lungs.Tanimilast was used in the study of obstructive lung disease.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 64,500 |
5 mg | 在庫あり | ¥ 158,500 |
10 mg | 在庫あり | ¥ 225,500 |
25 mg | 在庫あり | ¥ 335,000 |
50 mg | 在庫あり | ¥ 452,500 |
100 mg | 在庫あり | ¥ 608,500 |
説明 | Tanimilast (CHF-6001) is a novel, potent and selective phosphodiesterase 4 inhibitor with an IC 50 value of 0.026 ± 0.006 nM.Tanimilast has potent anti-inflammatory activity and is indicated for topical use in the lungs.Tanimilast was used in the study of obstructive lung disease. |
ターゲット&IC50 | PDE4:0.026±0.006 nM |
In vitro | Methacholine-induced protein expression of smooth muscle-myosin was fully inhibited by CHF-6001 (0.3-100 nM; Guinea pig precision-cut lung slices). CHF-6001 did not affect airway closure and had limited effects on TGF-β1-induced remodeling, but rather, it inhibited methacholine-induced TGF-β release.[2] |
別名 | CHF-6001 |
分子量 | 687.54 |
分子式 | C30H30Cl2F2N2O8S |
CAS No. | 1239278-59-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (72.72 mM)
You can also refer to dose conversion for different animals. 詳細
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Tanimilast 1239278-59-1 Metabolism PDE CHF 6001 CHF-6001 CHF6001 Inhibitor inhibitor inhibit