Powder: -20°C for 3 years | In solvent: -80°C for 1 year
WDR5-0102 is a compound that inhibits the WDR5-MLL1 interface (K dis = 7 μM, K d = 4 μM), selectively reducing MLL1 HMT activity without affecting the human H3K4 methyltransferase SETD7 or other HMTs, including G9a, EHMT1, SUV39H2, SETD8, PRMT3, and PRMT5.
説明 | WDR5-0102 is a compound that inhibits the WDR5-MLL1 interface (K dis = 7 μM, K d = 4 μM), selectively reducing MLL1 HMT activity without affecting the human H3K4 methyltransferase SETD7 or other HMTs, including G9a, EHMT1, SUV39H2, SETD8, PRMT3, and PRMT5. |
ターゲット&IC50 | WDR5-MLL1:4 μM(Kd), SHP2 (human):1.8 µM, WDR5-MLL1:7 μM(Kdis) |
In vitro |
Bioassay-guided fractionation resulted in the isolation of Mauritianin as a new topoisomerase I inhibitor.[1] After 14 weeks, Mauritianin antagonized the flavonol glycosides on cell-mediated immunosuppression in the two-stage carcinogenesis in terms of initiation.[3] |
分子量 | 374.82 |
分子式 | C18H19ClN4O3 |
CAS No. | 824960-50-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45.0 mg/mL (120.1 mM), Sonication and heating to 62℃ are recommended.
You can also refer to dose conversion for different animals. 詳細
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WDR5-0102 824960-50-1 Chromatin/Epigenetic Histone Methyltransferase Inhibitor inhibitor inhibit