A monoclonal antibody is secreted by a single B lymphocyte clone which can only produce a kind of proprietary antibody against an antigen-determining cluster, and has the characteristics of single biological activity and particular specificity of binding with antigen.
The active sites of monoclonal antibody drugs involve a variety of tumor-related signaling pathways and targets. For example, the most common targets are epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), and epidermal growth factor receptor -2 (her-2 /neu, or egfr-2). Besides, there is a group of targets that are getting a lot of attention called “immune checkpoints”.
After the activation of immune cells that regulate the anti-tumor immune response, a variety of highly expressed receptors on the surface of immune cells bind to the highly expressed ligands on the surface of tumor cells to reduce the strength of the immune response, thus down-regulating the intensity of tumor-related immune response. These immunoregulatory sites are known as immune checkpoints. Currently, the most widely studied immune checkpoints are PD-1, PD-L1, and CTLA-4.
Targetmol provides 30 monoclonal antibody drugs, including the above immune checkpoint inhibitors and other types of targeted antibody inhibitors, for scientific research only.
Cat. No. | 製品名 | CAS No. | Purity | Chemical Structure |
---|---|---|---|---|
T76975 | Tomaralimab | 1449294-76-1 | 98% |
Tomaralimab
|
Tomaralimab (OPN-305) is a humanized IgG4 monoclonal antibody targeting TLR2. Tomarlimab is used to study myelodysplastic syndromes (MDS). | ||||
T76957 | Belimumab | 356547-88-1 | 98% |
|
Belimumab(LymphoStat B) is a human IgG1λ monoclonal antibody that inhibits B-cell activating factor (BAFF).Belimumab is used in the study of fatigue and in the t... | ||||
T76956 | Vixarelimab | 2243320-83-2 | 98% |
|
Vixarelimab (KPL-716) is a human anti-oncostatin M (OSM) monoclonal antibody with affinity for the beta chain of the OSM receptor and inhibition of IL-31 and OSM... | ||||
T76941 | Carotuximab | 1268714-50-6 | 98% |
Carotuximab
|
Carotuximab (DE-122) is a novel endocholine antibody with strong antiangiogenic and anti-inflammatory activity. Carotuximab blocks endothelial glycoprotein (CD10... | ||||
T76927 | Bersanlimab | 1987854-08-9 | 98% |
|
Bersanlimab (BI-505) is a fully human monoclonal antibody targeting Intercellular Adhesion Molecule-1 (ICAM-1).Bersanlimab has anticancer properties and can be u... | ||||
T76924 | Efalizumab | 214745-43-4 | 98% |
Efalizumab
|
Efalizumab, a novel potent regulator of T cells, is a humanized LFA-1 α subunit (CD11a) monoclonal antibody. Efalizumab has inhibitory effects on T cell activati... | ||||
T76910 | Astegolimab | 2173054-79-8 | 98% |
|
Astegolimab (RG 6149) is a humanised IgG2 monoclonal antibody that targets the IL-33 receptor and inhibits IL-33 signalling. Astegolimab is used in the study of ... | ||||
T76907 | Palivizumab | 188039-54-5 | 98% |
|
Palivizumab (MEDI 493) is a humanized RSV-specific monoclonal antibody that selectively inhibits epitopes at the F protein A antigenic site of RSV subtypes A and... | ||||
T76896 | Abrezekimab | 2043952-59-4 | 98% |
Abrezekimab
|
Abrezekimab (VR 942) is composed of CDP7766, leucine, and trehalose. Abrezekimab is a humanized antibody that targets human IL-13. Abrezekimab inhibits binding t... | ||||
T76892 | Ordesekimab | 879293-15-9 | 98% |
Ordesekimab
|
Ordesekimab (AMG 714) is a human IgG1 κ-anti-IL-15 (Interleukin Related) monoclonal antibody. Ordesekimab binds competitively to IL-15, inhibiting the interactio... | ||||
T76891 | Oxelumab | 1186098-83-8 | 98% |
Oxelumab
|
Oxelumab (R 4930) is a human monoclonal antibody for OX40L. Oxelumab could be used to study asthma. | ||||
T76890 | Petosemtamab | 2213450-26-9 | 98% |
Petosemtamab
|
Petosemtamab (MCLA 158) is a highly potent monoclonal antibody against EGFR (Kd: 0.22 nM) and LGR5 (Kd: 0.86 nM). Petosemtamab promotes EGFR signaling disruption... | ||||
T76888 | Quetmolimab | 2084037-83-0 | 98% |
Quetmolimab
|
Quetmolimab is a humanized monoclonal antibody targeting chemokine ligand 1 (CX3CL1) that can be used to study rheumatoid arthritis. | ||||
T76884 | Spesolimab | 2097104-58-8 | 98% |
Spesolimab
|
Spesolimab (BI 655130) is an anti-interleukin-36 receptor antibody. IL-36 plays an important role in the immune system and is associated with a reduction in biom... | ||||
T76883 | Talacotuzumab | 1826831-79-1 | 98% |
Talacotuzumab
|
Talacotuzumab (JNJ 56022473) is an IgG1 fully humanized CD123 neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has a high affin... | ||||
T76882 | Talquetamab | 2226212-40-2 | 98% |
|
Talquetamab (JNJ-64407564) is a T-cell retargeting GPRC5D bispecific antibody for multiple myeloma with antitumor activity that induces T-cell-mediated killing o... | ||||
T76877 | Vofatamab | 1312305-12-6 | 98% |
|
Vofatamab (B-701) is a fully human monoclonal antibody targeting FGFR3. Vofatamab has potential anticancer and antitumor activity and is often used in combinatio... | ||||
T76874 | Erenumab | 1582205-90-0 | 98% |
Erenumab
|
Erenumab is a whole-human monoclonal antibody. Erenumab inhibits calcitonin gene-related peptide (CGRP) receptors. Erenumab can be used to prevent migraine attac... | ||||
T76873 | Nidanilimab | 2171061-85-9 | 98% |
Nidanilimab
|
Nidanilimab (CAN04) is a fully humanized IL1RAP monoclonal antibody with a Kd value of 1.10 pM. Nidanilimab has antitumor activity, cutting off the IL1α and IL1β... | ||||
T76870 | Narsoplimab | 2108782-45-0 | 98% |
Narsoplimab
|
Narsoplimab (OMS 721) is a selective whole-human immunoglobulin gamma-4 (IgG4) monoclonal antibody, a mannan-binding lectin-associated serine protease-2 (MASP-2)... |