|
T8961 |
GW280264X
|
Carbamic acid |
MMP
|
|
GW280264X (Carbamic acid) is an inhibitor of ADAM17 . |
|
T27603 |
INCB3619
|
INCB-3619,INCB 3619 |
Immunology/Inflammation related
|
|
INCB3619 is a selective and potent inhibitor of ADAM with antitumour effects, inhibiting ADAM10, ADAM17, MMP12 and MMP15. |
|
T4122 |
TAPI-1 trifluoroacetate (163847-77-6(free base))
|
|
MMP
|
|
TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. |
|
T27654 |
JG26
|
JG 26,JG-26 |
MMP
,
Immunology/Inflammation related
|
|
JG26 is a potent inhibitor of ADAM17, which can inhibit ADAM8, ADAM17, ADAM10 and MMP-12, with IC50 values of 12 nM, 1.9 nM, 150 nM and 9.4 nM, respectively, and can be used to study the immune system of the body. |
|
T7522 |
GI254023X
|
GI 254023X |
MMP
,
Immunology/Inflammation related
|
|
GI254023X is a potent MMP9 and ADAM10 inhibitor (IC50s: 2.5 and 5.3 nM) with 100-fold selectivity for the α-secretase ADAM10 over ADAM17 (TACE). GI254023X can remarkably inhibit the proliferation and induce the apoptosis... |
|
T6009 |
TAPI1
|
TAPI 1,TAPI,TAPI-1 |
MMP
|
|
TAPI1 (TAPI) , an ADAM17/TACE inhibitor, inhibits shedding of cytokine receptors. |
|
T13410 |
ZLDI-8
|
|
Apoptosis
,
Phosphatase
,
Gamma-secretase
,
Immunology/Inflammation related
|
|
ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein. |
|
T27592 |
IK-862
|
IK 862 |
|
|
IK-862 is a selective inhibitor of TACE (ADAM17). |
|
T26105 |
Ro 32-7315
|
Ro-327315,Ro327315,Ro 32 7315 |
|
|
Ro 32-7315 is a selective inhibitor of ADAM17. |
|
T63390 |
(S,S)-TAPI-1
|
|
|
|
(S,S)-TAPI-1 is an isomer of TAPI-1. Among them, TAPI-1 is a metalloproteinase (MMP) inhibitor and a TACE (ADAM17) inhibitor that exhibits potent inhibition of a variety of cell surface protein shedding. |
|
T40901 |
Aderbasib
|
INCB007839,INCB7839 |
|
|
Aderbasib (INCB007839) is a highly potent and orally active hydroxamate-based inhibitor of ADAM10 and ADAM17, with low nanomolar affinity. This compound demonstrates strong antineoplastic activity and holds potential for... |
|
T28985 |
TMI-1
|
WAY-171318 |
Apoptosis
,
MMP
|
|
TMI-1 (WAY-171318), a novel orally active inhibitor of ADAM17 (TACE) and MMP, induces tumor apoptosis in a breast cancer. |
|
T77778 |
KP-457
|
TNF‐α‐converting enzyme |
|
|
KP-457 (TNF-α-converting enzyme) is a selective inhibitor of ADAM17, with an IC50 value of 11.1 nM/L in cell-free assays. The compound can also cleave a variety of molecules, including GPIbα, GPV and TNF-α. |
