|
T1944 |
LDN-214117
|
|
ALK
,
TGF-beta/Smad
|
|
LDN-214117 is a potent and selective ALK2 inhibitor. |
|
T1935 |
LDN193189
|
LDN-193189,DM-3189,LDN 193189 |
ALK
,
TGF-beta/Smad
|
|
LDN193189 (LDN-193189) (DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of ALK2 and ALK3 (IC50s: 0.8/0.8/5.3/16.7 nM for ALK1/2/3/6). |
|
T10287 |
ALK2-IN-2
|
|
ALK
,
TGF-beta/Smad
|
|
ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) (IC50: 9 nM), inhibiting ALK2 700-fold more than ALK3. |
|
T35348 |
LDN-193189 2HCl
|
LDN-193189 2HCl,DM-3189 2HCl |
ALK
,
TGF-beta/Smad
|
|
LDN-193189 2HCl (DM-3189 2HCl) is a selective BMP signaling inhibitor that inhibits ALK1,ALK2,ALK3 and ALK6, showing IC50s of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM, respectively, in kinase assays.LDN-193189 2HCl inhibited ... |
|
T1943 |
ML347
|
LDN 193719 |
ALK
,
TGF-beta/Smad
|
|
ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3. |
|
T1977 |
Dorsomorphin
|
Compound C,BML-275 |
AMPK
,
Autophagy
,
TGF-beta/Smad
|
|
Dorsomorphin (BML-275) is an AMPK inhibitor (Ki=109 nM) that is selective and ATP-competitive. Dorsomorphin inhibits the BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin induces autophagy, and possesses antitumor ... |
|
T24897 |
TP0427736
|
TP427736,TP-0427736,TP-427736 |
TGF-beta/Smad
|
|
TP-0427736 is a novel potent and selective ALK5 inhibitor (IC50: 2.72 nM). P0427736 was 300-fold higher than the inhibitory effect on ALK3. TP0427736 reduces TGF-β induced growth inhibition in human outer root sheath cel... |
|
T1914 |
K02288
|
K 02288 |
ALK
,
TGF-beta/Smad
|
|
K 02288 is a novel small molecule inhibitor of ALK1/2/3/6. |
|
T1942 |
DMH-1
|
DMH1 |
ALK
,
Autophagy
,
TGF-beta/Smad
|
|
DMH-1 is a potent and selective BMP inhibitor. |
|
T1900 |
LDN-212854
|
LDN212854,BMP Inhibitor III |
ALK
,
TGF-beta/Smad
|
|
LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors; possesses differences towards ALK2(IC50=1.3 nM) versus ALK1/3 compared to other inhibitors. |
|
T6146 |
Dorsomorphin dihydrochloride
|
BML-275 2HCl,Compound C dihydrochloride,Dorsomorphin (Compound C) 2HCl,Compound C 2HCl,BML-275 dihydrochloride |
AMPK
,
Autophagy
,
TGF-beta/Smad
|
|
Dorsomorphin dihydrochloride (BML-275 2HCl) is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity on structurally related kinases. |
|
T63897 |
LDN193189 Tetrahydrochloride
|
|
|
|
LDN193189 Tetrahydrochloride is a selective inhibitor of BMPI-type receptors and inhibits ALK2 (IC50: 5 nM) and ALK3 (IC50: 30 nM), with weak effects on ALK4, ALK5 and ALK7 (IC50 ≥ 500 nM). |
|
T6158 |
LDN-193189 HCl
|
LDN193189 Hydrochloride |
ALK
|
|
LDN-193189 HCl (LDN193189 Hydrochloride) is a selective BMP type I receptor kinases inhibitor. |
|
T61029 |
TP0427736 hydrochloride
|
|
|
|
TP0427736 hydrochloride can be used in the androgenic alopecia (AGA) research. TP0427736 hydrochloride inhibits the phosphorylation of Smad2/3 in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM. TP0427736 hydr... |
