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T80221 |
TAT-BH4 (Bcl-xL)
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Apoptosis
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TAT-BH4 (Bcl-xL), primarily localized at the mitochondria, inhibits apoptotic cell death. This compound comprises an N-terminal eosin-labeled cysteine and the protein transduction domain of the HIV TAT protein (amino aci... |
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T80222 |
TAT-BH4 (Bcl-xL) (TFA)
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Apoptosis
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"TAT-BH4 (Bcl-xL) TFA, primarily localized at the mitochondria, inhibits apoptotic cell death. This compound comprises an eosin-labeled cysteine at the N-terminal and the protein transduction domain from the HIV TAT prot... |
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T21366 |
Sapropterin free base
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BPH4,Dapropterin,6R-BH4,Tetrahydro-6-biopterin,THB,Phenoptin |
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Sapropterin is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of dopamine, epinephrine, melatoni... |
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T6778 |
BDA-366
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BCL
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BDA-366, a potent Bcl2 antagonist, selectively binds the Bcl2-BH4 domain with high affinity (Ki = 3.3 nM), inducing a conformational change that nullifies its antiapoptotic function, thereby transforming it into a pro-ap... |
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T7461 |
2,4-Diamino-6-hydroxypyrimidine
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DAHP |
Reactive Oxygen Species
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NO Synthase
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2,4-Diamino-6-hydroxypyrimidine (DAHP) (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis |
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T16924 |
SPR inhibitor 3
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SPRi3 |
Others
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SPR inhibitor 3 is an effective sepiapterin reductase inhibitor. SPR inhibitor 3 decreases neuropathic and inflammatory pain through a reduction of BH4 levels. SPR inhibitor 3 shows a high binding affinity to human SPR i... |
