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T14776 |
BRD4 Inhibitor-10
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Epigenetic Reader Domain
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BRD4 Inhibitor-10 is an inhibitor of BRD4-BD1 (IC50: 8 nM). |
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T78555 |
BRD4 Inhibitor-27
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Epigenetic Reader Domain
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BRD4 Inhibitor-27 is a potent BRD4 inhibitor that inhibits BRD4 BD1 and BRD4 BD2 with IC50s of 9.6 and 11.3 μM, respectively.BRD4 Inhibitor-27 has anticancer activity and can be used for breast cancer research. |
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T77339 |
BRD4-IN-4
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Epigenetic Reader Domain
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BRD4-IN-4 is a selective BRD4 inhibitor with an IC50 value of 6.83 μM for BRD4.BRD4-IN-4 selectively inhibits the proliferation of the MV4-11 cell line and arrests the cells in G1 phase.BRD4-IN-4 can be used to study MLL... |
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T12551 |
PROTAC BRD4 ligand-1
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Epigenetic Reader Domain
,
Ligands for Target Protein for PROTAC
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PROTAC BRD4 ligand-1 is a ligand for BRD4 for Protac GNE-987 and an inhibitor of BET. |
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T9629 |
BRD4 Inhibitor-24
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Epigenetic Reader Domain
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BRD4 Inhibitor-24 is a BRD4 small molecule inhibitor with antitumor activity. |
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T40305 |
BRD4-IN-2
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BRD4-IN-2 |
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BRD4-IN-2 is a bromodomain BRD4 inhibitor with an IC 50 value of 9.9 nM. |
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T61318 |
BRD4 Inhibitor-20
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Epigenetic Reader Domain
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BRD4 Inhibitor-20 is a potent bromodomain protein 4 (BRD4) inhibitor with oral activity. BRD4 Inhibitor-20 has antiproliferative activity in cancer cell lines and is used in studies of various cancers, such as colon canc... |
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T50048 |
BRD4 Inhibitor 31
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Others
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4,4-dimethyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-one is a benzodiazepine derivative. It is an orthosteric modulator of the GABAA receptor and selectively binds to the benzodiazepine site of the GABAA receptor. It h... |
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T50022 |
BRD4 Inhibitor 30
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Others
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4-(2-fluorophenyl)-2,3-dihydro-1,3-thiazol-2-one is a thiazol-2-one analog that has been found to possess anti-inflammatory, antibacterial, antifungal, and antitumor activities. |
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T40073 |
PROTAC BRD4 Degrader-10
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PROTAC BRD4 Degrader-10 |
PROTACs
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PROTAC BRD4 Degrader-10, also known as compound 8b, is a dual ligand-based PROTAC that combines ligands for von Hippel-Lindau and BRD4. To degrade the BRD4 protein in PC3 prostate cancer cells, PROTAC BRD4 Degrader-10 ca... |
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T40075 |
PROTAC BRD4 Degrader-13
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PROTAC BRD4 Degrader-13 |
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PROTAC BRD4 Degrader-13 (compound 9d) is a bioactive compound that functions as a proteolysis targeting chimera (PROTAC), linking ligands for von Hippel-Lindau and BRD4 proteins. In the context of PC3 prostate cancer cel... |
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T40074 |
PROTAC BRD4 Degrader-15
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PROTAC BRD4 Degrader-15 |
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PROTAC BRD4 Degrader-15 is a chemical compound consisting of a PROteolysis TArgeting Chimera (PROTAC) linked to ligands specific to von Hippel-Lindau and BRD4. It exhibits an IC50 of 7.2 nM for BRD4 BD1 and 8.1 nM for BR... |
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T36242 |
PROTAC BRD4 Degrader-5
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PROTAC BRD4 Degrader-5 |
PROTACs
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PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1]. |
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T36628 |
PROTAC BRD4 Degrader-8
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PROTAC BRD4 Degrader-8 |
PROTACs
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PROTAC BRD4 Degrader-8 is a potent BRD4 inhibitor, with IC50s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells... |
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T39628 |
PROTAC BRD4 ligand-2
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PROTAC BRD4 ligand-2 |
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PROTAC BRD4 ligand-2 is a ligand for target BRD4 protein for PROTAC CFT-2718. |
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T40072 |
PROTAC BRD4 Degrader-9
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PROTAC BRD4 Degrader-9 |
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PROTAC BRD4 Degrader-9 (compound 8a) is a novel chemical compound consisting of ligands for von Hippel-Lindau and BRD4, connected by a PROTAC moiety. This compound can effectively degrade the BRD4 protein in PC3 prostate... |
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T64117 |
BRD4-BD1-IN-2
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Epigenetic Reader Domain
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BRD4-BD1-IN-2 is a selective and potent BRD4-BD1 inhibitor with an IC50 value of 2.51 µM, which is 20-fold greater than the inhibitory activity against BRD4-BD2.BRD4-BD1-IN-2 can be used in the study of cardiovascular an... |
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T30580 |
BRD4-Kinases-IN-3
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BRD4 kinases inhibitor 3,BRD4-Kinases inhibitor-3 |
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BRD4-Kinases-IN-3 is a dual BRD4-Kinases inhibitor that can be used as a value-added multi-targeted chemical probe for cancer therapy. |
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T39629 |
BRD4 ligand-Linker Conjugate 1
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BRD4 ligand-Linker Conjugate 1 |
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BRD4 Ligand-Linker Conjugate 1 is a compound consisting of a ligand and a linker, specifically designed to bind to the target protein BRD4. This conjugate serves as a valuable tool for synthesizing PROTACs, molecules uti... |
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T4365 |
FL-411
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FL 411,FL411,BRD4-IN-1 |
Epigenetic Reader Domain
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FL-411 (BRD4-IN-1) is a potent and selective BRD4 inhibitor with an IC50 of 0.43±0.09 μM for BRD4. |
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T5439 |
BRD4 degrader AT1
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Epigenetic Reader Domain
,
PROTACs
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BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells. |
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T13833 |
PROTAC BRD4 Degrader-1
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Epigenetic Reader Domain
,
PROTACs
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PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM). |
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T13834 |
PROTAC BRD4 Degrader-2
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Epigenetic Reader Domain
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PROTAC BRD4 Degrader-2 is an efficacious degrader of PROTAC BRD4(BRD4 BD1,IC50 of 14.2 nM). |
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T13835 |
PROTAC BRD4 Degrader-3
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Epigenetic Reader Domain
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PROTAC BRD4 Degrader-3 is an efficacious degrader of PROTAC BRD4. |
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T18598 |
PROTAC BRD2/BRD4 degrader-1
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Others
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PROTAC BRD2/BRD4 degrader-1 (compound 15) serves as a potent, selective degrader of BET proteins BRD4 and BRD2, achieving rapid, reversible, and unexpectedly selective elimination of BRD4 and BRD2 compared to BRD3. Its e... |
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T18599 |
PROTAC BRD4-binding moiety 1
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Others
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PROTAC BRD4-binding moiety 1 is a BRD4 ligand that binds to the cereblon ligand through a linker, enabling the formation of a PROTAC complex. This complex efficiently degrades BRD4[1]. |
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T18603 |
PROTAC BRD4 degrader for PAC-1
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Others
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PROTAC BRD4 degrader for PAC-1 (compound 5) is a chimeric BET degrader GNE-987 conjugated with a disulfide-containing linker[1]. This PROTAC-linker conjugate specifically targets and degrades BRD4, enabling selective pro... |
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T72636 |
BRD4 Inhibitor-26
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BRD4 Inhibitor-26, a bromodomain protein 4 (BRD4) inhibitor/nitric oxide-donator, exhibits inhibitory activity against BRD4 (BD1) and BRD4 (BD2) with IC50 values of 0.82 μM and 1.94 μM, respectively. It is utilized in ov... |
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T63302 |
BRD4 Inhibitor-19
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BRD4 inhibitors -19 are BET inhibitors that act on BRD4-BD1 (IC50: 55 nM) and can be used to study multiple myeloma. |
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T73830 |
BRD4 Inhibitor-16
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BRD4 Inhibitor-16 (Compound 4) is a potent inhibitor of bromodomain 4 (BRD4), whose overexpression is closely correlated with various human cancers through the regulation of histone post-translational modifications. It s... |
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T63352 |
BRD4 Inhibitor-18
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BRD4 Inhibitor-18 is a potent BRD4 inhibitor (IC50: 110 nM) with a hydrophobic acetylcyclopentane side chain. BRD4 Inhibitor-18 significantly reduces the proliferation of MV-4-11 cells with high BRD4 levels, inhibits G0/... |
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T61187 |
BRD4 Inhibitor-17
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BRD4 Inhibitor-17 (Compound 5i) is a highly potent inhibitor of BRD4, exhibiting an impressive IC50 value of 0.33 μM. It fulfills a crucial regulatory function in transcription by effectively modulating the expression of... |
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T78851 |
BRD4 Inhibitor-28
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Epigenetic Reader Domain
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BRD4 Inhibitor-28 (Compound 18), an orally active molecule, selectively inhibits the bromodomains of BRD4 (BRD4-BD1 and BRD4-BD2) with IC50 values of 15 and 55 nM, respectively. It also demonstrates inhibition of BRD2-BD... |
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T62883 |
BRD4 Inhibitor-23
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BRD4 Inhibitor-23 is a potent, orally active BRD4 inhibitor that acts on BRD4 BD-1 (IC50: 6.21 nM) and BRD4 BD-2 (IC50: 1.44 nM). |
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T61327 |
BRD4 Inhibitor-15
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BRD4 Inhibitor-15 (compound 13) is a highly potent and specific inhibitor of BRD4, effectively inhibiting it with an IC50 of 18 nM. By regulating the Bcl-2/Bax proteins and activating the caspase-3 signaling pathway, BRD... |
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T72630 |
BRD4 Inhibitor-25
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BRD4 Inhibitor-25, a chemical compound targeting the BD1 and BD2 domains of BRD4 with half-maximal inhibitory concentrations (IC50s) of 0.82 μM and 1.94 μM respectively, demonstrates efficacy in inducing apoptotic and au... |
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T78647 |
PROTAC BRD4 Degrader-16
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PROTACs
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PROTAC BRD4 Degrader-16 is a potent degrader of BRD4, exhibiting IC50 values of 34.58 nM for BRD4 (BD1) and 40.23 nM for BRD4 (BD2). It significantly reduces Cyclin B1 expression, thereby impeding G2/M phase progression,... |
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T74126 |
PROTAC BRD4 Degrader-14
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PROTAC BRD4 Degrader-14, a PROTAC (Proteolysis Targeting Chimera) linked by ligands to von Hippel-Lindau and BRD4, exhibits IC50 values of 1.8 nM and 1.7 nM for BRD4 BD1 and BD2, respectively. This compound effectively d... |
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T75149 |
PROTAC BRD4 Degrader-19
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PROTACs
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PROTAC BRD4 Degrader-19 (compound 176) is a proteolysis-targeting chimera (PROTAC) designed to specifically degrade the BRD4 protein, offering potential utility in cancer research [1]. |
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T74125 |
PROTAC BRD4 Degrader-12
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PROTAC BRD4 Degrader-12 (compound 9c) is a PROTAC that links von Hippel-Lindau and BRD4 ligands. When conjugated with STEAP1 and CLL1 antibodies, this compound effectively degrades BRD4 protein in PC3 prostate cancer cel... |
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T74270 |
PROTAC BRD4 Degrader-17
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PROTAC BRD4 Degrader-17 (compound 13i), a potent inhibitor, exhibits IC50 values of 29.54 nM (BRD4 (BD1)) and 3.82 nM (BRD4 (BD2)), effectively reducing Cyclin B1 expression linked with G2/M phase progression and signifi... |
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T62030 |
BRD4-BD1-IN-1
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BRD4-BD1-IN-1 (Compound 9a) is a BRD4-BD1 inhibitor(IC50= 38.20 μM). |
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T63471 |
PARP1/BRD4-IN-1
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PARP1/BRD4-IN-1 is a highly selective and potent inhibitor of PARP1 (IC50: 49 nM) and BRD4 (IC50: 202 nM).PARP1/BRD4-IN-1 inhibits the expression and activity of PARP1 and BRD4, thereby synergistically suppressing the ma... |
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T64058 |
PLK1/BRD4-IN-1
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PLK1/BRD4-IN-1 (9b) is an orally active dual inhibitor of PLK1 (IC50: 22 nM) and BRD4 (IC50: 109 nM). It has been shown to have good anti-tumour effects in vivo. |
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T79818 |
PROTAC BRD4 Degrader-21
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Epigenetic Reader Domain
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PROTAC BRD4 Degrader-21 (Comp 74), a potent degrader of BRD4, has demonstrated substantial inhibition of tumor growth in mouse xenograft models, showing its potential for use in anticancer research [1]. |
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T81386 |
PROTAC BRD4 Degrader-22
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Epigenetic Reader Domain
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PROTAC BRD4 Degrader-22 (Compd 44h) is a PROTAC-based degrader targeting BRD4, exhibiting a pDC50 of 9.2 in MOLT4 cells over 24 hours [1]. |
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T64089 |
BRD4 D1-IN-1
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BRD4 D1-IN-1 is a selective inhibitor of BRD4 D1 with an IC50 <0.092 μM. BRD4 D1-IN-1 has an affinity of 18 nM and over 500-fold selectivity for BRD4 D1 and BRD4 D2. |
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T74090 |
PROTAC BRD4 Degrader-7
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PROTAC BRD4 Degrader-7, a potent bromodomain BRD4 inhibitor exemplified by compound 1a, demonstrates half-maximal inhibitory concentrations (IC50s) of 15.5 nM and 12.3 nM for BRD4-BD1 and BRD4-BD2, respectively [1]. |
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T64192 |
BRD4 D1-IN-2
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BRD4 D1-IN-2 (compound 26) is a selective and potent inhibitor of BRD4 D1 with an IC50 value of less than 0.092 μM. BRD4 D1-IN-2 has a 15 nM affinity for BRD4 D1 and is more than 500-fold selective for BRD2 D1 and BRD4 D... |
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T62540 |
PARP1/BRD4-IN-2
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PARP1/BRD4-IN-2 is a potent and selective inhibitor of PARP1 (IC50: 197 nM) and BRD4 (IC50: 238 nM).PARP1/BRD4-IN-2 inhibits DNA damage repair, blocks the G0/G1 cell cycle transition, and induces apoptosis.PARP1/BRD4-IN-... |
