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T22195 |
CBFβ Inhibitor
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5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine |
DNA/RNA Synthesis
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CBFβ Inhibitor (5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine) is a cell-permeable CBFβ inhibitor and inhibits its association with Runx1. |
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T4687 |
Ro5-3335
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CBFβ-Runx1 inhibitor II,Ro 5-3335 |
DNA/RNA Synthesis
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Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). Ro5-3335 represses RUNX1/CBFβ-dependent transactivation ... |
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T9016 |
AI-10-47
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1H-Benzimidazole, 2-(2-pyridinyl)-6-(trifluoromethoxy)-AI-10-47 |
Others
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AI-10-47 (1H-Benzimidazole, 2-(2-pyridinyl)-6-(trifluoromethoxy)-AI-10-47) is a small molecule inhibitor of CBFβ-RUNX binding(IC50 : 3.2 μM). |
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T6753 |
AI-10-49
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DNA/RNA Synthesis
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AI-10-49 is a selective inhibitor of the binding of CBFβ-SMMHC to RUNX1 with IC50 of 260 nM. |
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T1748 |
Kartogenin
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KGN |
TGF-beta/Smad
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Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes. |
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T24550 |
NSC-140873
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GCPK |
Others
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NSC-140873 is the RUNX1-CBFβ interaction inhibitor. |
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T69678 |
WUN40378
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Others
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WUN40378 is compound first reported in PCT Int. Appl. (2019), WO 201909959, in which it was described as CBFβ-RUNX1 inhibitor. WUN40378 is very similar to Ro 5-3335 but with an F instead of Cl. WUN40378 is also analog of... |
