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カタログ番号 | 製品名 | 別名 | ターゲット |
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T21548 | PF-4981517 | CYP3cide | P450 |
PF-4981517 (CYP3cide) is a efficient, specific and time-dependent inhibitor of cytochrome P4503A4 (CYP3A4). The IC 50 values for CYP3A activity are 0.03 μM,17 μM, and 71 μM for CYP3A4, CYP3A5, and CYP3A7, respectively. P... | |||
T84532 | 11α-hydroxy Testosterone | Others | |
11α-Hydroxy Testosterone, a testosterone metabolite, is synthesized by the cytochrome P450 (CYP) isoform CYP3A.1, and can alternatively be produced from testosterone by a CYP107A1 mutant or from 11α-hydroxy progesterone ... |
カタログ番号 | 製品名 | 別名 | ターゲット |
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T19792 | 1,3,7-Trimethyluric acid | Others | |
1,3,7-Trimethyluric acid is a purine alkaloid that occurs as a minor metabolite of caffeine in humans. As an antioxidant, it has shown an ability to scavenge hydroxyl radicals as well as protective potential against lipi... | |||
T2926 | Schizandrin A | P450 , Virus Protease , Autophagy | |
Schisandrin A, a primary active component extracted from the traditional Eastern medicine Schisandra chinensis, inhibits CYP3A activity, with an IC50 of 6.60 μM and a Ki of 5.83 μM. | |||
T6S0119 | Dauricine | Apoptosis , Others , NF-κB | |
1. Dauricine has pulmonary toxicity, can produce pulmonary injury in CD-1 mice by the metabolism of Dauricine mediated by CYP3A. 2. Dauricinec can pass the blood-brain barrier, and that P-glycoprotein has an important ro... | |||
TN3146 | 6',7'-Dihydroxybergamottin acetonide | Others | |
6',7'-Dihydroxybergamottin is a potent inhibitor of CYP3A activity, and may be primarily responsible for the effects of grapefruit juice on cytochrome P450 activity in humans. |