|
T6459 |
Cyclosporine
|
|
Phosphatase
|
|
Cyclosporine is a calcineurin phosphatase pathway inhibitor, used as an immunosuppressant drug to prevent rejection in organ transplantation. |
|
T9936 |
ZX-J-19J
|
N-(2,3-Diphenyl-6-quinoxalinyl)octanamide |
Others
|
|
ZX-J-19J (N-(2,3-Diphenyl-6-quinoxalinyl)octanamide), an inhibitor of Cyclophilin J (CyPJ), demonstrates remarkable inhibition of tumor cell growth, comparable to cyclosporine A but much stronger than 5-fluorouracil. |
|
T28080 |
Mocravimod
|
KRP 203 free base,KRP-203,KRP203 |
|
|
Mocravimod is an agonist of sphingosine 1-phosphate receptor type 1. Mocravimod ameliorates atherosclerosis in LDL-R-/- mice. KRP-203 attenuates rat autoimmune myocarditis. KRP-203 combined with cyclosporine prolonged gr... |
|
T70889 |
Oxeclosporin
|
|
|
|
Oxeclosporin is a hydroxyethyl derivative of serine(8)-cyclosporine; inhibits proliferation and functions of lymphocytes. |
|
T32020 |
Gusperimus
|
Deoxyspergualin,15-Deoxyspergualin |
|
|
Gusperimus was synthesized by chemical modification of spergualin and in combination with cyclosporine A to prevent diabetes in susceptible NOD mice. |
|
T0679 |
Ketoconazole
|
R-41400,Xolegel,(±)-Ketoconazol,Extina |
NADPH-oxidase
,
P450
,
Hydroxylase
,
Antifungal
,
Ras
|
|
Ketoconazole (R-41400), a CYP3A4 inhibitor, is an imidazole anti-fungal agent. |
|
T34999 |
UNIL-088
|
UNIL 088 |
|
|
UNIL088 is a water-soluble prodrug of cyclosporine A (CsA) designed for topical ocular delivery. The pro-moiety is grafted via an ester function to CsA and the solubilizing group is a phosphate ion. UNIL-088 can be rapid... |
