FADD | TargetMol

カタログ番号	製品名	別名	ターゲット
T3560	Desmethylanethol trithione	ADT-OH	VEGFR , Akt
	Desmethylanethol trithione (ADT-OH) is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, Desmethylanethol trithione markedly...		VEGFR , Akt
T9095	Necrostatin-34	2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4	RIP kinase
	Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain.		RIP kinase
T11259	FadD32 Inhibitor-1		Others
	FadD32 inhibitor -1 has anti-tuberculosis activity and is an effective FadD32 inhibitor.		Others
T37558	Necrostatin-5	Nec-5	RIP kinase , Necroptosis
	Necrostatin-5 (Nec-5) is a selective inhibitor of RIP1 kinase and a cell necrosis inhibitor that prevents the death of Fadd-deficient Jurkat cells treated with TNF-α with an EC50 value of 240 nM.		RIP kinase , Necroptosis
T12203L	Necrostatin 2		Others
			Others

Compounds

Desmethylanethol trithione

T3560

Synonym: 2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4

Target: RIP kinase, Necroptosis

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-01315	CASR Protein, Human, Recombinant (GST)	Human	E. coli
	CASR Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 93.6 kDa and the accession number is P41180.
TMPH-01057	Caspase-8 Protein, Human, Recombinant (His)	Human	E. coli
	Caspase-8 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 21.9 kDa and the accession number is Q14790.
TMPH-02650	FCMR/FAIM3 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory...
TMPH-02876	RIPK1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways. Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold fun...
TMPK-00277	TRAIL R2/DR5/TNFRSF10B Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter mol...
TMPJ-00696	NOL3 Protein, Human, Recombinant	Human	E. coli
	Nucleolar protein 3 is encoded by NOL3 gene. Multiple transcript variants encoding different isoforms have been found for this gene. So far, Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in...
TMPY-02213	RAIDD Protein, Human, Recombinant (His)	Human	E. coli
	Death domain-containing protein CRADD, also known as Caspase and RIP adapter with death domain, RIP-associated protein with a death domain, CRADD and RAIDD, is a protein which is constitutively expressed in most tissu...
TMPJ-00215	Fas/CD95 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Mouse Apoptosis-mediating surface antigen FAS (Fas) belongs to the death receptor subfamily of the TNF receptor superfamily and is designated TNFRSF6. Mouse Fas contains 1 death domain and 3 TNFR-Cys repeats. It detected...
TMPH-02521	PYCARD Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mit...