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RIP kinase

RIP kinases (receptor-interacting protein kinases) are a class of serine/threonine protein kinases. In humans, five different RIP kinases are known:RIPK1,RIPK2,RIPK3,RIPK4,RIPK5.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T63544 RIPK3-IN-1 2361139-70-8 98%
RIPK3-IN-1 is a selective and potent RIPK3 inhibitor (IC50: 9.1 nM) that inhibits the activities of c-Met kinase, RIPK1 and RIPK2.RIPK3-IN-1 has potential tumori...
T35694 OD36 1638644-62-8 98%
OD36 is a selective and potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 inhibits ALK2 signaling and osteogenic differentiation (KD: 37 nM), and binds efficien...
T83640 RIPK2-IN-5 2885227-09-6 98%
RIPK2-IN-5 is a receptor-interacting protein kinase 2 (RIPK2) inhibitor with potential anti-inflammatory activity for the study of diseases caused by immune dysf...
T7397 GSK547 2226735-55-1
GSK547 (GSK'547) is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.
T9702 Eclitasertib 2125450-76-0
Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).
T15437 GSK3145095 1622849-43-7 100%
GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.
T11484 GSK2593074A 1337531-06-2 100%
GSK2593074A (GSK'074) is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3.
T1847 Necrostatin-1 4311-88-0 100%
Necrostatin-1 (Nec-1) is a necrotic apoptosis inhibitor and RIP1 inhibitor with specificity. Necrostatin-1 inhibits TNF-α-induced necrotic apoptosis. Necrostatin...
T7795 RIPA-56 1956370-21-0 100%
RIPA-56 is an inhibitor of RIP1
T9095 Necrostatin-34 375835-43-1 97%
Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distin...
T5401 GSK2983559 active metabolite 1423186-80-4 97.07%
GSK2983559 active metabolite (RIPK2-IN-1) is a potent, selective receptor-interacting protein-2 (RIP2) kinase inhibitor.
T5054 GSK963 2049868-46-2 97.45%
GSK963 (Racemate), a structurally distinct, potent and selective inhibitor of RIP1 kinase(IC50=29 nM).
T6815 HS-1371 2158197-70-5 98%
HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.
T12731 RIPK1-IN-7 2300982-44-7 98.02%
RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimen...
T37558 Necrostatin-5 337349-54-9 98.03%
Necrostatin-5 (Nec-5) is a selective inhibitor of RIP1 kinase and a cell necrosis inhibitor that prevents the death of Fadd-deficient Jurkat cells treated with T...
T12493 PK68 2173556-69-7 98.13%
PK68 is an effective and selective inhibitor of type II receptor-interacting kinase 1 (RIPK1, IC50 = 90 nM). PK68 can be used for research on the treatment of in...
T12728 RIP2 Kinase Inhibitor 3 1398053-50-3 98.35%
RIP2 Kinase Inhibitor 3 is a potent and selective inhibitor of RIP2 with an IC50 of 1 nM.
T24152 HTH-01-091 2000209-42-5 98.40%
HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK...
T11492 GSK2983559 free acid 1579965-12-0 98.61%
GSK2983559 free acid is an effective and selective inhibitor of receptor-interacting protein 2 (RIP2). GSK2983559 free acid shows excellent activity in blocking ...
T3537 GSK583 1346547-00-9 98.68%
GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).
RIPK3-IN-1
T63544
RIPK3-IN-1 is a selective and potent RIPK3 inhibitor (IC50: 9.1 nM) that inhibits the activities of c-Met kinase, RIPK1 and RIPK2.RIPK3-IN-1 has potential tumori...
OD36
T35694
OD36 is a selective and potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 inhibits ALK2 signaling and osteogenic differentiation (KD: 37 nM), and binds efficien...
RIPK2-IN-5
T83640
RIPK2-IN-5 is a receptor-interacting protein kinase 2 (RIPK2) inhibitor with potential anti-inflammatory activity for the study of diseases caused by immune dysf...
GSK547
T7397
GSK547 (GSK'547) is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.
Eclitasertib
T9702
Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).
GSK3145095
T15437
GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.
GSK2593074A
T11484
GSK2593074A (GSK'074) is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3.
Necrostatin-1
T1847
Necrostatin-1 (Nec-1) is a necrotic apoptosis inhibitor and RIP1 inhibitor with specificity. Necrostatin-1 inhibits TNF-α-induced necrotic apoptosis. Necrostatin...
RIPA-56
T7795
RIPA-56 is an inhibitor of RIP1
Necrostatin-34
T9095
Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distin...
GSK2983559 active metabolite
T5401
GSK2983559 active metabolite (RIPK2-IN-1) is a potent, selective receptor-interacting protein-2 (RIP2) kinase inhibitor.
GSK963
T5054
GSK963 (Racemate), a structurally distinct, potent and selective inhibitor of RIP1 kinase(IC50=29 nM).
HS-1371
T6815
HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.
RIPK1-IN-7
T12731
RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimen...
Necrostatin-5
T37558
Necrostatin-5 (Nec-5) is a selective inhibitor of RIP1 kinase and a cell necrosis inhibitor that prevents the death of Fadd-deficient Jurkat cells treated with T...
PK68
T12493
PK68 is an effective and selective inhibitor of type II receptor-interacting kinase 1 (RIPK1, IC50 = 90 nM). PK68 can be used for research on the treatment of in...
RIP2 Kinase Inhibitor 3
T12728
RIP2 Kinase Inhibitor 3 is a potent and selective inhibitor of RIP2 with an IC50 of 1 nM.
HTH-01-091
T24152
HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK...
GSK2983559 free acid
T11492
GSK2983559 free acid is an effective and selective inhibitor of receptor-interacting protein 2 (RIP2). GSK2983559 free acid shows excellent activity in blocking ...
GSK583
T3537
GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).
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