RIP kinase

RIP kinases (receptor-interacting protein kinases) are a class of serine/threonine protein kinases. In humans, five different RIP kinases are known:RIPK1,RIPK2,RIPK3,RIPK4,RIPK5.

Cat. No.	製品名	CAS No.	Purity
T5054	GSK963	2049868-46-2	98%
T5054	GSK963 (Racemate), a structurally distinct, potent and selective inhibitor of RIP1 kinase(IC50=29 nM).
T9702	Eclitasertib	2125450-76-0	98%
T9702	Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).
T35694	OD36	1638644-62-8	98%
T35694	OD36 is a selective and potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 inhibits ALK2 signaling and osteogenic differentiation (KD: 37 nM), and binds efficien...
T9095	Necrostatin-34	375835-43-1	98%
T9095	Necrostatin-34 is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain.
T7397	GSK547	2226735-55-1	98%
T7397	GSK547 is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.
T15437	GSK3145095	1622849-43-7	98%
T15437	GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.
T7795	RIPA-56	1956370-21-0	98%
T7795	RIPA-56 is an inhibitor of RIP1
T5401	GSK2983559 active metabolite	1423186-80-4	98%
T5401	GSK 2983559 (RIP2 kinase inhibitor 1) is a potent, selective receptor-interacting protein-2 (RIP2) kinase inhibitor.
T7504	Necrostatin 2 racemate	852391-15-2	98%
T7504	Necrostatin 2 racemate is an potent and specific inhibitor of RIPK1.
T6815	HS-1371	2158197-70-5	98%
T6815	HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.
T12731	RIPK1-IN-7	2300982-44-7	98%
T12731	RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimen...
T37558	Necrostatin-5	337349-54-9	98%
T37558	Necrostatin-5 is a selective inhibitor of RIP1 kinase and a cell necrosis inhibitor that prevents the death of Fadd-deficient Jurkat cells treated with TNF-α wit...
T12493	PK68	2173556-69-7	98%
T12493	PK68 is an effective and selective inhibitor of type II receptor-interacting kinase 1 (RIPK1, IC50 = 90 nM). PK68 can be used for research on the treatment of in...
T11492	GSK2983559 free acid	1579965-12-0	98%
T11492	GSK2983559 free acid is an effective and selective inhibitor of receptor-interacting protein 2 (RIP2). GSK2983559 free acid shows excellent activity in blocking ...
T3537	GSK583	1346547-00-9	98%
T3537	GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).
T9072	Tuxobertinib	2414572-47-5	98%
T9072	BDTX-189 is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reape...
T7151	GSK2982772	1622848-92-3	98%
T7151	GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.
T8931L	ICCB-19 hydrochloride	1803605-68-6	98%
T8931L	ICCB-19 HCl is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N), whic...
T9305	Necroptosis-IN-1	1391980-92-9	98%
T9305	Necroptosis-IN-1 is a potent necroptosis inhibitor of RIPK1. It is an analog of Necrostatin-1.
T4074	GSK-872	1346546-69-7	98%
T4074	GSK872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activi...