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T79323 |
PROTAC Hsp90α degrader 1
|
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HSP
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Compound X10g (PROTAC Hsp90α degrader 1) is a selective agent targeting Hsp90α for degradation and is utilized in breast cancer research. It demonstrates inhibitory effects on the proliferation of breast cancer cell line... |
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T8958 |
PU-H54
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GPR
|
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PU-H54 is a purine-based inhibitor of Grp94. It is a Grp94-selective resorcinol-based inhibitor isolated through probing of the exclusive binding region of S2 subpocket in Grp94. |
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T6609 |
NMS-E973
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HSP
|
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NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases. |
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T16994 |
Pimitespib
|
TAS-116 |
HSP
|
|
Pimitespib (TAS-116) is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively). |
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T6118 |
NVP-HSP990
|
HSP990 |
Apoptosis
,
HSP
|
|
NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM). |
|
T1989 |
Luminespib
|
AUY922,VER-52296,NVP-AUY922 |
Apoptosis
,
HSP
,
Autophagy
|
|
Luminespib (VER-52296) is a new-type inhibitor of HSP90 (IC50s: 7.8/21 nM for HSP90α/β in cell free assay). |
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T7261 |
Grp94 Inhibitor-1
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GPR
,
HSP
|
|
Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor (IC50 : 2 nM). |
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T6558 |
KW-2478
|
KW2478 |
HSP
|
|
KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM. |
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T24685 |
PU-20F
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|
|
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PU-20F is a selective inhibitor of Hsp90α and Hsp90 . |
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T15088 |
Debio 0932
|
CUDC-305 |
HSP
|
|
|
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T78809 |
NDNA3
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|
HSP
|
|
NDNA3 (compound 14) selectively inhibits Hsp90α with an IC50 of 0.51 μM, demonstrating low membrane permeability and minimal toxicity to Ovcar-8 and MCF-10A cells, with IC50 values of 12.66 μM and 11.72 μM respectively. ... |
|
T78808 |
NDNA4
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HSP
|
|
NDNA4 (compound 17) is a selective Hsp90α inhibitor (IC50: 0.34 μM), characterized by its permanent charge and low membrane permeability. It exhibits minimal cytotoxicity against Ovcar-8 and MCF-10A cell lines (IC50 >100... |
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T69365 |
HMS607P03
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HMS607P03 is an activator of SIRT1 which induces autophagic cell death via the AMPK-mTOR-ULK complex and induces mitophagy by the SIRT1-PINK1-Parkin pathway. HMS607P03 downregulates 14-3-3γ, catalase, profilin-1, and HSP... |
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T64261 |
HDAC/HSP90-IN-4
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|
|
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HDAC/HSP90-IN-4 significantly inhibited HDAC and HSP90 activity, with compound 20 (HDACIC50= 194 nM; HSP90αIC50= 153 nM) and compound 26 ((HDACIC50= 360 nM; HSP90αIC50= 77 nM) having the strongest HDAC and HSP90α inhibit... |
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T63528 |
HSP90-IN-11
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|
|
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HSP90-IN-11 is a potent inhibitor of HSP90 and induces significant accumulation of the sub-G1 population. HSP90-IN-11 has a potent HSP90α inhibitory effect comparable to that of AUY-922 (Luminespib). In CRC and NSCLC cel... |
|
T79486 |
MAO A/HSP90-IN-1
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|
Monoamine Oxidase
|
|
MAO A/HSP90-IN-1 (4-b) is a dual inhibitor of MAO A and HSP90, exhibiting IC50 values of 1.77 μM in glioblastoma (GBM) GL26 cells and 0.019 μM against HSP90α. This compound impairs the activities of MAO A, disrupts HSP90... |
