|
T41027 |
MLKL-IN-2
|
|
MLK
|
|
MLKL-IN-2 is an MLKL inhibitor with potential tumorigenic activity for the study of cellular necrosis-related diseases. |
|
T79731 |
MLKL-IN-6
|
|
Necroptosis
|
|
MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor that specifically targets the Mixed Lineage Kinase domain-like (MLKL) protein. It effectively prevents MLKL phosphorylation and oligomerization, which are crit... |
|
T73279 |
MLKL-IN-5
|
|
|
|
MLKL-IN-5 is a potent MLKL inhibitor that mediates necroptosis . |
|
T60885 |
MLKL-IN-1
|
|
|
|
MLKL-IN-1 is a covalent inhibitor of MLKL with a Kd value of 50 μM. |
|
T79831 |
PROTAC MLKL Degrader-1
|
|
|
|
PROTAC MLKL Degrader-1 (Compound 36) is a selective PROTAC degrader targeting MLKL, achieving a degradation maximum (D max) over 90%. The compound encompasses modified cereblon (CRBN) ligands and a lenalidomide-linker as... |
|
T7697 |
BIX-01294
|
|
Histone Methyltransferase
,
Autophagy
|
|
BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM). |
|
T1959 |
BIX-01294 trihydrochloride
|
BIX 01294 |
Histone Methyltransferase
,
Autophagy
|
|
BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase. |
|
T11520 |
GW806742X
|
|
MLK
,
VEGFR
|
|
GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd: 9.3 μM) with anti-necroptosis activity. GW806742X has activity against VEGFR2. |
|
T7129 |
(E/Z)-Necrosulfonamide
|
|
MLK
|
|
(E/Z)-Necrosulfonamide is a novel inhibitor of MLKL. |
|
T6904 |
Necrosulfonamide
|
(E)-Necrosulfonamide |
MLK
|
|
(E)-Necrosulfonamide ((E)-Necrosulfonamide) is an inhibitor of necroptosis. Blocks mixed lineage kinase domain-like protein (MLKL), a critical substrate of receptor-interacting serine-threonine kinase 3 (RIP3) during nec... |
|
T81268 |
RIPK1-IN-17
|
|
RIP kinase
|
|
RIPK1/3-IN-1 (Compound 10) is a selective inhibitor of both RIPK1 and RIPK3, effectively preventing necroptosis by blocking the phosphorylation of RIPK1, RIPK3, and MLKL [1]. |
|
T78784 |
RIPK3-IN-3
|
|
|
|
RIPK3-IN-3 (compound 20) is a selective RIPK3 inhibitor that demonstrates potent activity with an IC50 value of 10 nM. This compound effectively blocks RIPK3-mediated phosphorylation of MLKL, preventing its oligomerizati... |
|
T74681 |
NecroIr2
|
|
|
|
NecroIr2, an iridium(III) complex, functions as a necroptosis inducer in cisplatin-resistant lung cancer cells (A549R). It preferentially accumulates in mitochondria, causing oxidative stress and a reduction in mitochond... |
|
T74680 |
NecroIr1
|
|
|
|
NecroIr1, an iridium(III) complex, acts as a necroptosis inducer in Cisplatin-resistant lung cancer cells (A549R). It selectively targets mitochondria, causing oxidative stress and reducing mitochondrial membrane potenti... |
|
T17010 |
TC13172
|
|
Others
|
|
TC13172 is an inhibitor of mixed lineage kinase domain-like protein (EC50: 2 nM for HT-29 cells). |
