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Search Results for " N-methyltransferase "

ターゲット

Histone Methyltransferase Antifolate Histamine Receptor

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T8548	Metoprine		Histone Methyltransferase , Antifolate , Histamine Receptor
	Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity.		Histone Methyltransferase , Antifolate , Histamine Receptor
T8381	Amodiaquine		Others , Histone Methyltransferase , Parasite
	Amodiaquine is a synthetic aminoquinoline, used to treat malaria.		Others , Histone Methyltransferase , Parasite
T2038	RG108	N-Phthalyl-L-tryptophan	DNA Methyltransferase
	RG108 (N-Phthalyl-L-tryptophan) is an DNA methyltransferase inhibitor(IC50=115 nM).		DNA Methyltransferase
T2352	AMI-1		Histone Methyltransferase
	AMI-1 is an effective and selective Histone Methyltransferase (HMT) inhibitor (IC50: 3.0/8.8 μM, for yeast Hmt1p, and human PRMT1).		Histone Methyltransferase
T7157	XY1		Histone Methyltransferase
	XY1 is a very close analogue of SGC707 (a potent, selective, and non-competitive inhibitor of PRMT3 with IC50 of 31 nM), It is intended to be used as a negative control for SGC707 in studies involving PRMT3 action.		Histone Methyltransferase
T0381	Amodiaquine dihydrochloride dihydrate	Amodiaquine hydrochloride,Amodiaquin dihydrochloride dihydrate	Histone Methyltransferase , Parasite , Histamine Receptor
	Amodiaquine dihydrochloride dihydrate (Amodiaquine hydrochloride) is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties.		Histone Methyltransferase , Parasite , Histamine Receptor
T22956	LY 78335	1-(2,3-Dichlorophenyl)ethanamine hydrochloride	Others
	LY 78335 (1-(2,3-Dichlorophenyl)ethanamine hydrochloride) is a phenylethanolamine-N-methyltransferase (PNMT) inhibitor.		Others
T10363	Arazine	N-Acetyl-S-farnesyl-L-cysteine	Others
	Arazine (N-Acetyl-S-farnesyl-L-cysteine) can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site. Arazine is a cell-permeable modulator of G protein and G...		Others
T8106	JBSNF-000088	JBSNF000088	Others
	JBSNF-000088 is an Nicotinamide N-methyltransferase (NNMT)inhibitor. It is used for the treatment of metabolic disorders.		Others
T7697	BIX-01294		Histone Methyltransferase , Autophagy
	BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).		Histone Methyltransferase , Autophagy
T8760	NNMTi	5-Amino-1-methylquinolinium	Others
	NNMTi (5-Amino-1-methylquinolinium) is a substrate site-targeting, selective nicotinamide N-methyltransferase (NNMT) inhibitor (IC50 = 1.2 μM; 50 μM SAM, 100 μM NCA) that reduces 3T3-L1 lipogenesis (EC50 = 30μM) and adip...		Others
T1959	BIX-01294 trihydrochloride	BIX 01294	Histone Methyltransferase , Autophagy
	BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.		Histone Methyltransferase , Autophagy
T72947	JBSNF-000028	JBSNF-000028 free base	Others
	JBSNF-000028 is an orally active and potent nicotinamide N-methyltransferase (NNMT) inhibitor with inhibitory effects on human NNMT (hNNMT), monkey NNMT (mkNNMT), and mouse NNMT (mNNMT) with IC50s of 0.033 μM, 0.19 μM, a...		Others
T24604	PDAT	Propyl Dimethyl Amino Tryptamine
	PDAT is a noncompetitive Indolethylamine N-methyltransferase inhibitor.
T27831	Lifibrate
	Lifibrate is an inhibitor of cholinephosphotransferase (CPT), phosphatidyl-N,N-dimethylethanolamine N-methyltransferase (PDE-NMT), and phosphatidyl-N-methylethanolamine N-methyltransferase (PME-NMT).
T23367	SKF 91488 dihydrochloride		Others
	histamine N-methyltransferase inhibitor		Others
T27924	LY 87130	LY87130,LY-87130
	LY 87130 is a phenylethanolamine-N-methyltransferase inhibitor.
T27872	LY 134046	LY-134046,LY134046,Lilly 134046
	LY 134046 is an inhibitor of phenylethanolamine-N-methyltransferase (PNMT).
T68694	Quinacrine acetate
	Quinacrine acetate is a histamine N-methyltransferase inhibitor.
T71922	MS2734
	MS2734 is a novel Bisubstrate Inhibitor of Nicotinamide N-Methyltransferase (NNMT).
T37693	N-acetyl-S-geranylgeranyl-L-Cysteine
	N-acetyl-S-geranylgeranyl-L-Cysteine is a synthetic substrate for the isoprenylated protein methyltransferase (also known as S-adenosylmethionine-dependent methyltransferase). Because it is able to serve as a substrate f...
T70105	Chlorpromazine Sulfone Hydrochloride
	Chlorpromazine Sulfone Hydrochloride is a metabolite of Chlorpromazine -- an anti-emetic and anti-psychotic agent. It may also be used as a potential N-methyltransferase inhibitor.
T36802	Bisubstrate Inhibitor 78
	Bisubstrate inhibitor 78 is an inhibitor of nicotinamide N-methyltransferase (NNMT; IC50= 1.41 μM).1It binds the NNMT active site in the binding pockets for the NNMT substrates S-adenosyl-L-methionine (SAM) and nicotinam...
T26744	BAY-598 R-isomer	BAY598 R-isomer,BAY 598 R-isomer
	BAY-598 R-isomer is the R-isomer of BAY589, which is used as a reference compound. It is is an inhibitor of lysine N-methyltransferase (SMYD2) and is selective for SMYD2 over protease-activated receptor 1 (PAR1).
T83949	DC 432
	DC 432, a potent peptidomimetic inhibitor of N-terminal methyltransferase 1/2 (NTMT1/2) with an IC50 value of 54 nM, incorporates a BM30 peptide enhanced by five arginine residues. It effectively reduces the N-terminal m...
T28114	MS2177	MS 2177,MS-2177
	MS2177 is a potent and selective inhibitor of SETD8, the only methyltransferase known to catalyze monomethylation of histone H4 lysine 20 (H4K20). MS2177 has an in vitro IC50 of 1.9 μM (σ = 1.05 μM, n = 4) in ascintillat...
T22242	Amodiaquine hydrochloride
	Amodiaquine dihydrochloride (Amodiaquin dihydrochloride), a member of the 4-aminoquinoline class, serves as an antimalarial agent and exhibits potent oral activity as a histamine N-methyltransferase inhibitor, displaying...
T78164	JBSNF-000028 hydrochloride		Others
	JBSNF-000028 hydrochloride is a potent inhibitor of nicotinamide N-methyltransferase (NNMT) with IC50 values of 0.033 μM for human NNMT (hNNMT), 0.19 μM for monkey NNMT (mkNNMT), and 0.21 μM for mouse NNMT (mNNMT). This ...		Others
T82011	JBSNF-000028 free base
	JBSNF-000028 is an orally active inhibitor of nicotinamide N-methyltransferase (NNMT) demonstrating inhibitory concentration (IC50) values of 0.033 µM for human NNMT (hNNMT), 0.19 µM for monkey NNMT (mkNNMT), and 0.21 µM...
T78163	JBSNF-000028 TFA		Others
	JBSNF-000028 TFA, a nicotinamide N-methyltransferase (NNMT) inhibitor, exhibits oral activity with inhibitory concentration 50 (IC50) values of 0.033 μM, 0.19 μM, and 0.21 μM for human NNMT (hNNMT), monkey NNMT (mkNNMT),...		Others
T64189	NNMT-IN-3
	NNMT-IN-3 (compound 14) is a potent and selective inhibitor of nicotinamide N-methyltransferase (NNMT) with IC50 values of 1.1 nM and 0.4 μM in cell-free and cell-based assays, respectively. nNMT-IN-3 can be used in stud...
T83713	DC432 TFA
	DC432 is a cell-permeable peptide that serves as an inhibitor of N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1; IC50 = 0.054 µM), capable of binding to both NTMT1 and NTMT2 with dissociation constants (Kds) of 0.3 ...
T81432	PNMT-IN-1
	PNMT-IN-1 (inhibitor 4) is a selective second generation inhibitor [1] of phenylethanolamine N-methyltransferase (PNMT), exhibiting a Ki value of 1.2 nM and an IC50 value of 81 nM. Additionally, it disrupts the activity ...
T81661	NNMT-IN-4
	NNMT-IN-4 (compound 38) is a selective, uncompetitive inhibitor of nicotinamide N-methyltransferase (NNMT) with in vitro biochemical and cell-based assay IC50 values of 42 nM and 38 nM, respectively. It demonstrates favo...
T83867	UNC8153 TFA
	UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and NSD3 at 20 µM, and demonstrating a 50% degradation constant (DC50) of 350 nM. At a concentrati...

Compounds

Metoprine

T8548

Synonym:

Target: Histone Methyltransferase, Antifolate, Histamine Receptor

Amodiaquine

T8381

Synonym:

Target: Others, Histone Methyltransferase, Parasite

RG108

T2038

Synonym: N-Phthalyl-L-tryptophan

Target: DNA Methyltransferase

AMI-1

T2352

Synonym:

Target: Histone Methyltransferase

XY1

T7157

Synonym:

Target: Histone Methyltransferase

Amodiaquine dihydrochloride dihydrate

T0381

Synonym: Amodiaquine hydrochloride,Amodiaquin dihydrochloride dihydrate

Target: Histone Methyltransferase, Parasite, Histamine Receptor

LY 78335

T22956

Synonym: 1-(2,3-Dichlorophenyl)ethanamine hydrochloride

Target: Others

Arazine

T10363

Synonym: N-Acetyl-S-farnesyl-L-cysteine

Target: Histone Methyltransferase, Autophagy

NNMTi

T8760

Synonym: 5-Amino-1-methylquinolinium

Target: Others

BIX-01294 trihydrochloride

T1959

Synonym: BIX 01294

Target: Histone Methyltransferase, Autophagy

JBSNF-000028

T72947

Synonym: JBSNF-000028 free base

Target: Others

PDAT

T24604

Synonym: Propyl Dimethyl Amino Tryptamine

SKF 91488 dihydrochloride

Synonym: LY87130,LY-87130

Target:

LY 134046

T27872

Synonym: LY-134046,LY134046,Lilly 134046

N-acetyl-S-geranylgeranyl-L-Cysteine

T37693

Synonym:

Target:

Chlorpromazine Sulfone Hydrochloride

T70105

Synonym:

Target:

Bisubstrate Inhibitor 78

Synonym: BAY598 R-isomer,BAY 598 R-isomer

Synonym: MS 2177,MS-2177

Target:

Amodiaquine hydrochloride

T22242

Synonym:

Target:

JBSNF-000028 hydrochloride

T78164

Synonym:

Target: Others

JBSNF-000028 free base

カタログ番号	製品名	別名	ターゲット
T1354	N-Acetyl-5-hydroxytryptamine	Normelatonin,O-Demethylmelatonin,N-Acetylserotonin	Trk receptor , Endogenous Metabolite
	N-Acetyl-5-hydroxytryptamine (O-Demethylmelatonin) , also known as Normelatonin, is the immediate precursor of melatonin. It is produced from serotonin by the enzyme aralkylamine N-acetyltransferase and is converted to m...		Trk receptor , Endogenous Metabolite
T8790	1-Methylhistamine dihydrochloride		Endogenous Metabolite
	1-Methylhistamine dihydrochloride is a major metabolite of histamine by histamine N-methyltransferase in the pathway of histidine metabolism. It has been used as a biomarker of histaminergic system activity in the brains...		Endogenous Metabolite
T4909	N-Acetyl-DL-methionine		Others , Endogenous Metabolite
	N-acetyl-L-methionine is nutritionally and metabolically equivalent to L-methionine. Methionine is a dietary indispensable amino acid required for normal growth and development of humans, other mammals, and avian species...		Others , Endogenous Metabolite
T4120	N-Methylsarcosine	N,N-Dimethylglycine,N,N-Dimethylaminoacetic acid,Dimethylglycine,DMG	Endogenous Metabolite
	N-Methylsarcosine (Dimethylglycine) is used as an athletic performance enhancer and immunostimulant. It is also used in the treatment of autism, epilepsy and mitochondrial disease. It is also employed as a biomarker of p...		Endogenous Metabolite

天然物製品

N-Acetyl-5-hydroxytryptamine

T1354

Synonym: Normelatonin,O-Demethylmelatonin,N-Acetylserotonin

Target: Trk receptor, Endogenous Metabolite

1-Methylhistamine dihydrochloride

T8790

Synonym:

Target: Endogenous Metabolite

N-Acetyl-DL-methionine

T4909

Synonym:

Target: Others, Endogenous Metabolite

N-Methylsarcosine

T4120

Synonym: N,N-Dimethylglycine,N,N-Dimethylaminoacetic acid,Dimethylglycine,DMG

Target: Endogenous Metabolite

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPJ-01118	GNMT Protein, Human, Recombinant (His)	Human	E. coli
	Glycine N-Methyltransferase (GNMT) is a tetrameric cytosolic protein. GNMT catalyzes the synthesis of N-methylglycine from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. It can affects DNA methylation b...
TMPK-01308	TAG-72 Protein, Canine, Recombinant (His)	Canine	E. coli
	The guanine-N7 methyltransferase domain of vaccinia virus mRNA capping enzyme is a heterodimer composed of a catalytic subunit and a stimulatory subunit. Cap (guanine-N7) methylation is an essential step in eukaryal mRNA...
TMPJ-01114	GAMT Protein, Human, Recombinant (His)	Human	E. coli
	GAMT is a methyltransferase which belongs to the class I-like SAM-binding methyltransferase superfamily. It contains one RMT2 (arginine N-methyltransferase 2-like) domain and is expressed in liver. GAMT converts guanidoa...
TMPY-02340	HNMT Protein, Human, Recombinant (GST)	Human	E. coli
	HNMT (Histamine N-methyltransferase) is a Protein Coding gene. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. HNMT, the major enzyme for the metabol...
TMPH-02564	CARNMT1 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of ...
TMPY-01285	METTL11A Protein, Human, Recombinant	Human	E. coli
	METTL11A Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 25.5 kDa and the accession number is A0A024R8E4.
TMPY-01284	METTL11A Protein, Human, Recombinant (GST)	Human	E. coli
	METTL11A Protein, Human, Recombinant (GST) is expressed in E. coli expression system with GST tag. The predicted molecular weight is 52.2 kDa and the accession number is A0A024R8E4.
TMPH-01970	EEF2KMT Protein, Human, Recombinant (His)	Human	E. coli
	Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on 'Lys-525'. EEF2KMT Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is ...
TMPH-00313	TRNA (guanine-N(7)-)-methyltransferase Protein, Brugia malayi, Recombinant (His)	Brugia malayi	E. coli
	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. tRNA (guanine-N(7)-)-methyltransferase Protein, Brugia malayi, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. ...
TMPY-02420	HEMK2 Protein, Human, Recombinant (His)	Human	E. coli
	N6AMT1 (N-6 Adenine-Specific DNA Methyltransferase 1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene encodes an N(6)-adenine-specific DNA methyltransferase. It belongs to t...
TMPY-01708	DOT1L Protein, Human, Recombinant	Human	E. coli
	Histone-lysine N-methyltransferase, H3 lysine-79 specific, also known as Histone H3-K79 methyltransferase, DOT1-like protein, Lysine N-methyltransferase 4 and DOT1L, is a nucleus protein which belongs to theDOT1 famil...
TMPY-01229	SETD7 Protein, Human, Recombinant (His)	Human	E. coli
	Histone-lysine N-methyltransferase SETD7, also known as SET domain containing (lysine methyltransferase) 7, SET7/9, Histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, and SETD7, is a member of the histone-lysine ...
TMPH-02635	EEF1AKMT2 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'. EEF1AKMT2 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted...
TMPY-01657	SUV420H2 Protein, Human, Recombinant (His & GST)	Human	E. coli
	Histone-lysine N-methyltransferase SUV42H2, also known as Suppressor of variegation 4-2 homolog 2, Su(var)4-2 homolog 2, Lysine N-methyltransferase 5C, SUV42H2 and KMT5C, is nucleus protein that belongs to the histone-ly...
TMPH-02227	ERG Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure. ERG Protein, Human, Recombina...
TMPH-01529	INMT Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, ...
TMPY-01383	PRMT6 Protein, Human, Recombinant (His & Flag)	Human	HEK293 Cells
	Protein arginine N-methyltransferase 6, also known as Histone-arginine N-methyltransferase PRMT6, PRMT6, and HRMT1L6, is a member of the protein arginine N-methyltransferase family and PRMT6 subfamily. PRMT6 is highly ex...
TMPY-01661	METTL1 Protein, Human, Recombinant (His)	Human	E. coli
	tRNA (guanine-N(7)-)-methyltransferase, also known as Methyltransferase-like protein 1, tRNA (m7G46)-methyltransferase and METTL1, is a nucleus protein that belongs to the methyltransferase superfamily and TrmB family. M...
TMPY-01268	SMYD3 Protein, Human, Recombinant (GST)	Human	Baculovirus Insect Cells
	SET and MYND domain-containing protein 3, also known as Zinc finger MYND domain-containing protein 1, SMYD3, and ZMYND, is a member of the histone-lysine methyltransferase family. SMYD3 contains one MYND-type zinc finger...
TMPY-01270	PRMT3 Protein, Human, Recombinant (GST)	Human	E. coli
	Protein arginine methyltransferase 3, also known as PRMT3, is one of four type I protein arginine methyltransferases (PRMT) that in humans is encoded by the PRMT3 gene. Methylation of arginine residues is a widespread po...