Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Amodiaquine is a synthetic aminoquinoline, used to treat malaria.
説明 | Amodiaquine is a synthetic aminoquinoline, used to treat malaria. |
ターゲット&IC50 | Nurr1-LBD (ligand binding domain):20 μM (EC50) |
In vitro | Inflammatory responses are considered to play pivotal roles in the pathogenesis of intracerebral hemorrhage (ICH).?a nuclear receptor Nurr1 (NR4A2) was expressed prominently in microglia/macrophages and astrocytes in the perihematomal region in the striatum of mice after ICH.?Daily administration of a Nurr1 agonist amodiaquine (40 mg/kg, i.p.) from 3 h after ICH induction diminished perihematomal activation of microglia/macrophages and astrocytes.?Amodiaquine also suppressed ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice.?These results suggest that Nurr1 serves a novel target for ICH therapy. |
分子量 | 355.86 |
分子式 | C20H22ClN3O |
CAS No. | 86-42-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 71 mg/mL (199.52 mM)
You can also refer to dose conversion for different animals. 詳細
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Amodiaquine 86-42-0 Chromatin/Epigenetic Microbiology/Virology Others Histone Methyltransferase Parasite CCL2 Nurr1 IL-1β Amodiaquin inhibit Inhibitor anti-inflammatory CXCL2 neuroprotective antimalarial N-methyltransferase inhibitor