|
T7476 |
AS057278
|
3-Methylpyrazole-5-carboxylic acid |
Others
|
|
AS057278 (3-Methylpyrazole-5-carboxylic acid) is an D-amino acid oxidase (DAAO) inhibitor. |
|
T3472 |
CGS 27023A
|
|
MMP
|
|
CGS 27023A is a non-peptidic, potent, and orally active stromelysin inhibitor. |
|
T1980 |
HA14-1
|
|
BCL
|
|
HA14-1, a Bcl-2/Bcl-XL antagonist, is a non-peptidic ligand of a Bcl-2 surface pocket (IC50: ~9 μM). |
|
T61964 |
RXFP3/4 agonist 2
|
|
RXFP receptor
|
|
RXFP3/4 agonist 2 is a potent non-peptidic bis-RXFP3/4 agonist that induces the interaction between RXFP3 and β-arrestin-2, and can be used to study diseases caused by metabolic abnormalities. |
|
T2639 |
LY2811376
|
|
Beta Amyloid
,
Beta-Secretase
,
BACE
|
|
LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity towards BACE1 over BACE2, and more than 50-fold inhibition... |
|
T24735 |
RP-23618
|
|
Others
|
|
RP-23618 is a non-peptidic antagonist of RANTES. |
|
T24625 |
PF-184563
|
PF184563,PF 184563 |
Others
|
|
PF-184563 is an effective and selective non-peptidic V1a receptor antagonist. |
|
T71596 |
Bag-2
|
|
Others
|
|
Bag-2 is a Novel potent, non-peptidic bombesin receptor subtype-3 (BRS-3) agonist. |
|
T71595 |
Bag-1
|
|
Others
|
|
Bag-1 is a novel potent, non-peptidic bombesin receptor subtype-3 (BRS-3) agonist. |
|
T70471 |
Cgs 26303
|
|
Others
|
|
Cgs 26303 is a potent non-peptidic inhibitor of neutral endopeptidase capable of protecting atrial natriuretic peptide from enzymatic degradation. |
|
T71091 |
Y2-Antagonist-2
|
|
Others
|
|
Y2-Antagonist-2 is a novel, selective, soluble non-peptidic NPY Y2 receptor antagonist with enhanced CNS exposure. |
|
T71997 |
CypD-IN-29
|
|
Others
|
|
CypD-IN-29 is a non-peptidic inhibitor of cyclophilin D as a neuroprotective agent in Aβ-induced mitochondrial dysfunction. |
|
T16986 |
Tanomastat
|
BAY 12-9566 |
MMP
|
|
Tanomastat is an orally bioavailable and non-peptidic biphenyl matrix metalloproteinases inhibitor. For MMP-2, MMP-3, MMP-9, MMP-13 the Ki values are 11, 143, 301, and 1470 nM respectively. |
|
T40358 |
Ensitrelvir fumarate
|
S-217622 fumarate |
Others
|
|
Ensitrelvir (S-217622) fumarate is a novel orally active inhibitor, targeting the SARS-CoV-2 3CL protease (IC50 = 13 nM). It demonstrates non-covalent and non-peptidic characteristics. This compound represents a pioneeri... |
|
T74939 |
HIV protease-IN-1
|
|
Others
|
|
HIV protease-IN-1 (compound 1·succinate), a potent non-peptidic inhibitor of HIV protease, is utilized for AIDS research [1]. |
|
T74097 |
THX-B
|
|
Others
|
|
THX-B, a potent non-peptidic antagonist of the neurotrophin receptor p75 (p75 NTR), is utilized in the study of diabetic kidney disease, neurodegenerative, and inflammatory disorders [1] [2] [3]. |
