PRMT1 | TargetMol

カタログ番号	製品名	別名	ターゲット
T38421	PRMT1-IN-1	PRMT1-IN-1
	PRMT1-IN-1 is a PRMT1 inhibitor.
T27133	DCLX069	DCLX 069,DCLX-069	Histone Methyltransferase
	DCLX069 is a potent and selective PRMT1 inhibitor. DCLX069 occupies the SAM binding pocket to exert the inhibitory effect. DCLX069 effectively blocks cell proliferation in breast cancer, liver cancer and acute myeloid le...		Histone Methyltransferase
T2352	AMI-1		Histone Methyltransferase
	AMI-1 is an effective and selective Histone Methyltransferase (HMT) inhibitor (IC50: 3.0/8.8 μM, for yeast Hmt1p, and human PRMT1).		Histone Methyltransferase
T7697	BIX-01294		Histone Methyltransferase , Autophagy
	BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).		Histone Methyltransferase , Autophagy
T1959	BIX-01294 trihydrochloride	BIX 01294	Histone Methyltransferase , Autophagy
	BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.		Histone Methyltransferase , Autophagy
T2097	C-7280948	C7280948	Histone Methyltransferase
	C-7280948 is a PRMT1 inhibitor.		Histone Methyltransferase
T21826	TC-E 5003	NSC 30176	Histone Methyltransferase
	TC-E 5003 (NSC-30176) is a selective inhibitor of PRMT1 with IC50 of 1.5 μM.		Histone Methyltransferase
T11500L	GSK3368715 dihydrochloride	EPZ019997 dihydrochloride,GSK3368715 2HCl,EPZ019997 2HCl	Histone Methyltransferase
			Histone Methyltransferase
T6900	MS023		Histone Methyltransferase
	MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, respectively.		Histone Methyltransferase
T10682L	CARM1-IN-1	CARM1-IN-7G	Histone Methyltransferase
	CARM1-IN-1 (CARM1-IN-7G) is a selective inhibitor of CARM1 with IC50 of 8.6 μM. CARM1-IN-1 shows weak activity against PRMT1 and SET7 with IC50 > 600 μM.		Histone Methyltransferase
T61338	MS023 dihydrochloride	MS023 2HCl	Histone Methyltransferase
	MS023 dihydrochloride (MS023 2HCl) is a selective, cytosolic and highly potent inhibitor of human type I protein arginine methyltransferases (PRMTs) with antitumour activity, inhibits PRMT1, PRMT3, PRMT4, PRMT6, and PRMT...		Histone Methyltransferase
T4393	MS049 2HCl (1502816-23-0(free base))		Histone Methyltransferase
	MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM). It is less active against additional type I PRMTs (IC50s = >130, >220, and 1.6 μM for PRMT1, PRMT3, and PRMT8, respectively) and...		Histone Methyltransferase
T11338	Furamidine	DB75,NSC 305831	Others
	Furamidine is also a selective and cell-permeable protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 μM, 28...		Others
T22342	GSK3368715 3HCl	EPZ019997 3HCl,GSK3368715(EPZ019997)	Histone Methyltransferase
	GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 nM.		Histone Methyltransferase
TP2041	C 21
	Selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.8 μM). Exhibits five-fold selectivity for PRMT1 over PRMT6 and >250-fold selectivity over PRMT3 and CARM1.
T11500	GSK3368715	EPZ019997	Histone Methyltransferase
			Histone Methyltransferase
T77787	MS023 trihydrochloride	MS023 3HCl	Histone Methyltransferase
	MS023 trihydrochloride (MS023 3HCl) is a selective and potent human type I protein arginine methyltransferase (PRMT) inhibitor with potential anticancer activity against PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8 for cancer r...		Histone Methyltransferase
T27395	Furamidine dihydrochloride	DB 75, DB75, NSC 305831, WR199385,Furamidine HCl
	Furamidine is a cell-permeable, selective inhibitor of protein arginine methyltransferase 1 (PRMT1). Furamidine binds to strings of AT base pair sequences in DNA′s minor groove. Furamidine targets the enzyme active site ...
T64186	CARM1-IN-1 hydrochloride
	CARM1-IN-1 hydrochloride is a potent and selective inhibitor of CARM1 (IC50: 8.6 μM) with low inhibition of PRMT1 and SET7.
T72013	Epigenetic Multiple Ligand
	Epigenetic Multiple Ligand is a cell-permeable inhibitor of substrate processing by several chromatin-associated enzymes, including SIRT1/2, H3/SET7, H3/p300/CBP, H4/RmtA, PABP1/CARM1, and H4/PRMT1. It acts by inducing e...
T19243	CMP-5 hydrochloride		Others
	CMP-5 hydrochloride is a potent and selective PRMT5 inhibitor, while displays no activity against PRMT1/4/7 enzymes. It selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations.		Others
T22325	EPZ020411 hydrochloride	EPZ020411 HCl	Histone Methyltransferase
	EPZ020411 hydrochloride is a selective and potent small molecule PRMT6 inhibitor with an IC50 value of 10 nM.		Histone Methyltransferase
T10967	DC_C66		Others
	DC_C66 DC_C66 has good selectivity for CARM1, PRMT1 (IC50 = 21μM), PRMT6 (IC50 = 47μM) and PRMT5. It is a cell-permeable, selective co-activator related arginine methyltransferase 1 (CARM1) inhibitor with IC50 of 1.8 μM.		Others
T23030	MS023 (hydrochloride) (1831110-54-3 free base)	MS023 (hydrochloride)	Others
	MS023 is a type I PRMT inhibitor (IC50: 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectively).		Others
T15080	DC-05		DNA Methyltransferase , Histone Methyltransferase
	DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).		DNA Methyltransferase , Histone Methyltransferase
T81399	PRMT4-IN-2
	PRMT4-IN-2 (compound 55) acts as a pan-inhibitor across various protein arginine methyltransferase (PRMT) isoforms, exhibiting inhibitory potencies with IC50 values of 92 nM for PRMT4, 436 nM for PRMT6, 460 nM for PRMT1,...
T22239	AMI-1, free acid
	AMI-1 free acid is a potent, cell-permeable, and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), demonstrating inhibitory concentration 50 (IC50) values of 8.8 μM for human PRMT1 and 3.0 μM for yea...
T36802	Bisubstrate Inhibitor 78
	Bisubstrate inhibitor 78 is an inhibitor of nicotinamide N-methyltransferase (NNMT; IC50= 1.41 μM).1It binds the NNMT active site in the binding pockets for the NNMT substrates S-adenosyl-L-methionine (SAM) and nicotinam...
T4314	EPZ020411	EPZ020411 2HCl	Histone Methyltransferase
	EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).		Histone Methyltransferase
T4334	EPZ020411 2HCl (1700663-41-7(free base))		Histone Methyltransferase
	EPZ020411 is an effective and specific small molecule PRMT6 inhibitor (IC50=10 nM).		Histone Methyltransferase
T68378	PRMT4-IN-1		Histone Methyltransferase
	PRMT4-IN-1 is a selective inhibitor of PRMT4, demonstrating an IC50 value of 3.2 nM, and has been shown to reduce the relative viability of MCF7 cells [1].		Histone Methyltransferase