Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively).
説明 | DC-05 is an inhibitor of DNA methyltransferase 1 (DNMT1) (IC50 and a Kd: 10.3 μM and 1.09 μM, respectively). |
ターゲット&IC50 | PRMT1:37.1 μM, DNMT1:1.09 μM (kd), DNMT1:10.3 μM |
In vitro | DC-05 is a non-nucleoside DNMT1 inhibitor with low micromolar IC50 values and significant selectivity toward other AdoMet-dependent protein methyltransferases.?DC-05 (1.25, 2.5, 5, and 10 μM) effectively inhibits the proliferation of HCT116 (human colon cancer) and Capan-1 (human pancreatic adenocarcinoma cells) after treatment for 24, 48, and 72 h. DC-05 displays poor potent activities against DNMT3A, DNMT3B, G9a, SUV39H1, MLL1, SET7/9, and PRMT1 (IC50: >200, >200, >150, >150, >150, >150, 37.1 μM) [1]. |
分子量 | 383.49 |
分子式 | C25H25N3O |
CAS No. | 890643-16-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (260.76 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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DC-05 890643-16-0 Chromatin/Epigenetic DNA Methyltransferase Histone Methyltransferase Inhibitor DC 05 DC05 DNMTs DNA MTases inhibit inhibitor