SLF | TargetMol

カタログ番号	製品名	別名	ターゲット
T13888	SLF		Others
	SLF is a synthetic ligand for FK506-binding protein (FKBP)( with an affinity of 3.1 μM for FKBP51 and an IC50 of 0.22 μM for FKBP12). SLF can be used in the synthesis of PROTAC.		Others
T18061	KB02-SLF		Others , PROTACs
	KB02-SLF is a PROTAC-based nuclear FKBP12 degrader, known as a molecular glue. It facilitates the degradation of nuclear FKBP12 by covalently modifying DCAF16, an E3 ligase. Moreover, KB02-SLF enhances the longevity of p...		Others , PROTACs
T13914	SLF-amido-C2-COOH	PROTAC FKBP12-binding moiety 1	Others
	SLF-amido-C2-COOH is a synthetic ligand for FKBP (SLF), and can be used in the synthesis of PROTACs.		Others
T73817	SLF TFA
	SLF TFA, a synthetic ligand for FK506-binding protein (FKBP), exhibits affinity toward FKBP51 with a value of 3.1 μM and demonstrates an IC50 of 2.6 μM for FKBP12. This compound is utilized in the synthesis of PROTAC [1]...
T61112	SLF1081851		LPL Receptor
	SLF1081851 is a Spns2 inhibitor. SLF1081851 inhibits S1P release with IC50 of 1.93 μM.		LPL Receptor
T62851	SLF1081851 TFA
	SLF1081851 (TFA) is a Spns2 inhibitor with an IC50 value of 1.93 μM for inhibition of S1P release.SLF1081851 (TFA) plays a key role in development and the immune system.
T74026	AUTAC2
	AUTAC2, an autophagy-mediated degrader (AUTAC) targeting FKBP12, comprises an FBnG (p-Fluorobenzyl Guanine) and an SLF (c ligand of FKBP) moiety. The SLF component binds non-covalently to FKBP12 [1].
T18597	DFKBP-1		Others , PROTACs
	dFKBP-1 is a potent and PROTAC-based FKBP12 degrader. dFKBP-1 incorporates the ligand SLF of FKBP12, the Thalidomide based cereblon ligand and a linker[1].		Others , PROTACs
T80928	TSPO ligand-3		AUTACs
	TSPO ligand-3, functioning as an AUTAC2 ligand, incorporates both a p-fluorobenzylguanine (FBnG) and a synthetic ligand of FKBP (SLF) moiety, leading to the substantial inhibition of FKBP12 in HeLa cells [1].		AUTACs
T39923	KB02-COOH	KB02-COOH
	KB02-COOH is a synthetic fragment derived from ubiquitin E3 ligase ligand KB02, which possesses potential utility in the synthesis of PROTAC compounds. Notably, KB02-COOH can be employed in the generation of PROTAC const...

Compounds

SLF

T13888

Target: Others, PROTACs

SLF-amido-C2-COOH

T13914

Synonym: PROTAC FKBP12-binding moiety 1

Target: Others, PROTACs

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-02105	SCF Protein, Mouse, Recombinant (His)	Mouse	Baculovirus Insect Cells
	SCF Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 19.7 kDa and the accession number is P20826-1.
TMPY-05135	SCF Protein, Mouse, Recombinant (His), Biotinylated	Mouse	Baculovirus Insect Cells
	SCF Protein, Mouse, Recombinant (His), Biotinylated is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 19.7 kDa and the accession number is P20826-1.
TMPJ-00895	SCF Protein, Rat, Recombinant (HEK293, His)	Rat	HEK293 Cells
	SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, ...
TMPK-01441	HLA-A*02:01&B2M&PRAME (ALYVDSLFFL) Monomer Protein, Human, MHC (His & Avi)	Human	HEK293 Cells
	PRAME (PReferentially expressed Antigen in MElanoma) is a melanoma-associated antigen expressed in cutaneous and ocular melanomas and some other malignant neoplasms, while its expression in normal tissue and benign tumor...
TMPH-02063	SLFN12 Protein, Human, Recombinant (His)	Human	E. coli
	SLFN12 Protein, Human, Recombinant (His) is expressed in in vitro E. coli expression system.
TMPH-02062	SLFN11 Protein, Human, Recombinant (His)	Human	E. coli
	SLFN11 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 69.6 kDa and the accession number is Q7Z7L1.