|
T60029 |
SOS1-IN-11
|
|
Raf
|
|
SOS1-IN-11 is an effective inhibitor of SOS1 (IC50 = 30 nM). |
|
T73164 |
SOS1-IN-15
|
|
Raf
|
|
SOS1-IN-15 is an orally active and potent SOS1 inhibitor with potential antitumor activity.SOS1-IN-15 is used in the study of colon cancer. |
|
T12978 |
NSC-70220
|
SOS1-IN-1 |
Raf
|
|
SOS1-IN-1 is an inhibitor of SOS1. |
|
T63118 |
SOS1-IN-8
|
|
|
|
SOS1-IN-8 is an inhibitor of SOS1 and acts on SOS1-G12D (IC50: 11.6 nM) and SOS1-G12V (IC50: 40.7 nM). |
|
T62712 |
SOS1-IN-10
|
|
|
|
SOS1-IN-10 is a potent inhibitor of SOS1 that acts on KRAS G12C-SOS1 (IC50: 13 nM). |
|
T61963 |
SOS1-IN-3
|
|
|
|
SOS1-IN-3 is an effective inhibitor of SOS1 (son of sevenless homolog 1) (IC50=5 nM). SOS1-IN-3 shows antitumor activity. |
|
T79183 |
SOS1-IN-16
|
|
Ras
|
|
SOS1-IN-16 (Comp 54) serves as a selective SOS1 inhibitor exhibiting an IC50 value of 7.2 nM and demonstrates inhibitory activity against CYP3A4 with an IC50 of 8.9μM when testosterone is employed as a substrate. This co... |
|
T63044 |
SOS1-IN-6
|
|
|
|
SOS1-IN-6 (compound 33-P1) is a potent inhibitor of SOS1, acting on SOS1-G12D (IC50: 14.9 nM) and SOS1-G12V (IC50: 73.3 nM). |
|
T62003 |
SOS1-IN-13
|
|
|
|
SOS1-IN-13 is a potent inhibitor of son of sevenless homolog 1 (SOS1). SOS1-IN-13 shows IC 50 s of 6.5 nM and 327 nM for SOS1 and pERK, respectively. SOS1-IN-13 has research value in anticancer. |
|
T63083 |
SOS1-IN-4
|
|
|
|
SOS1-IN-4 is a potent inhibitor of SOS1 (IC50: 56 nM) and can be used in the study of KRAS-C12C/SOS1 interactions. |
|
T63781 |
SOS1-IN-5
|
|
|
|
SOS1-IN-5 is a pyrimidine bicyclic derivative and a potent inhibitor of SOS1. SOS1-IN-5 interferes with the RAS-SOS1 interaction, thereby blocking KRAS activation and exhibiting broad-spectrum inhibition of KRAS activity... |
|
T62923 |
SOS1-IN-7
|
|
|
|
SOS1-IN-7 (compound 18-p1) is a potent inhibitor of SOS1 and acts on SOS1-G12D (IC50: 20 nM) and SOS1-G12V (IC50: 67 nM). |
|
T62478 |
SOS1-IN-9
|
|
|
|
SOS1-IN-9 is a potent inhibitor of SOS1 that acts on KRAS G12C-SOS1 (IC50: 116.5 nM). |
|
T62371 |
SOS1-IN-12
|
|
|
|
SOS1-IN-12 is a potent inhibitor of SOS1, acting on SOS1 (Ki: 0.11 nM) and on pERK (IC50: 47 nM). |
|
T63887 |
SOS1-IN-14
|
|
|
|
SOS1-IN-14 is a selective, potent, orally active SOS1 inhibitor (IC50: 3.9 nM). sOS1-IN-14 is absorbed in the intestine using a P-glycoprotein-mediated efflux mechanism. sOS1-IN-14 can be used in the study of KRAS mutate... |
|
T63201 |
SOS1 activator 1
|
|
|
|
SOS1 activator 1 is an activator of SOS1-mediated nucleotide exchange (Kd: 44 nM).SOS1 is a guanine nucleotide exchange factor that binds to Ras proteins and catalyzes the exchange of GDP for GTP on RAS, resulting in the... |
|
T79162 |
SOS1/KRAS-IN-1
|
|
Ras
|
|
SOS1/KRAS-IN-1 (Compound 2) serves as an inhibitor of SOS1/KRAS, with potential application in the study of diseases mediated by SOS1/KRAS [1]. |
|
T79098 |
PROTAC SOS1 degrader-4
|
|
PROTACs
|
|
PROTAC SOS1 Degrader-4 (compound 10) is a potent degrader of SOS1 and exhibits antiproliferative activity [1]. |
|
T75020 |
PROTAC SOS1 degrader-3
|
|
|
|
PROTAC SOS1 Degrader-3 is a potent agent specifically designed to target and degrade SOS1 via the ubiquitin-proteasome system [1]. |
|
T74356 |
PROTAC SOS1 degrader-2
|
|
|
|
PROTAC SOS1 degrader-2, a potent degrader of PROTAC SOS1, effectively reduces the expression of pERK and RAS-GTP in a dose-dependent manner. It significantly inhibits tumor growth in vivo [1]. |
|
T74439 |
PROTAC SOS1 degrader-1
|
|
|
|
PROTAC SOS1 degrader-1, a potent compound, demonstrates an effective degradation of PROTAC SOS1 with a DC50 value of 98.4 nM. It exhibits antiproliferative activity against cancer cells harboring diverse KRAS mutations a... |
|
T12979 |
BI-3406
|
|
p38 MAPK
,
MAPK
,
Ras
|
|
BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity. |
|
TP2116 |
SAH-SOS1A
|
|
|
|
KRas/son of sevenless 1 (SOS1) interaction inhibitor. Binds within nucleotide binding pocket of KRas (Kd values are 106 - 176 nM for wild type KRas and various KRas mutants). Inhibits nucleotide binding to KRas in a conc... |
|
T76059 |
SAH-SOS1A TFA
|
|
|
|
SAH-SOS1A TFA is a peptide-based SOS1/KRAS protein interaction inhibitor. SAH-SOS1A TFA binds to wild-type and mutant KRAS (G12D, G12V, G12C, G12S, and Q61H) with nanomolar affinity ( EC 50 =106-175 nM). SAH-SOS1A TFA di... |
|
T5418 |
BAY-293
|
|
Raf
,
Ras
|
|
BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM). |
|
T38170 |
RMC-0331
|
RM-023 |
Raf
|
|
RMC-0331 (RM-023) is an orally available and potent SOS1 inhibitor.RMC-0331 has potential anticancer activity, blocking RAS activation by disrupting RAS-SOS1 interactions. |
|
T8721L |
I-37 free base( 2359690-13-2(free base))
|
|
Raf
|
|
I-37 free base is a novel benzylamino substituted pyridopyrimidinone as SOS1 inhibitor. |
|
T9755 |
MRTX0902
|
UNII-CRG69FR93G |
Raf
|
|
MRTX0902 is an effective and high selective inhibitor of SOS1 with an IC50 of 46 nM and a Ki of 2 nM. |
|
T69529 |
BI-0474
|
|
Ras
|
|
BI-0474 is a potent KRASG12C inhibitor that inhibits GDP-KRAS::SOS1 protein-protein interactions with an IC50 value of 7.0 nM.BI-0474 exhibits significant antiproliferative activity against NCI-H358 cells harboring the G... |
|
T8746L |
I-49 free base
|
Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-6-(tetrahydro-2H-pyran-4-yl)-,I-49 |
Raf
|
|
I-49 free base (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-6-(tetrahydro-2H-pyran-4-yl)-) is a novel benzylamino substituted pyridopyrimidinone as SOS1 inhibito... |
|
T24554 |
NSC-658497
|
NSC658497 |
|
|
NSC-658497 is a SOS1-Ras interaction inhibitor that acts by dose-dependently inhibiting SOS1 GEF activity. |
|
T71348 |
UC-773587
|
|
|
|
UC-773587 is a novel inhibitor of Ras signaling, binding to the Ras switch II interaction region of SOS1. |
|
T72347 |
KRAS G12C inhibitor 24
|
|
|
|
KRAS G12C Inhibitor 24 is a potent inhibitor that effectively disrupts the interaction between KRAS G12C and SOS1, achieving an inhibitory concentration (IC 50) of less than 50 nM. |
|
T72356 |
KRAS G12C inhibitor 56
|
|
|
|
KRAS G12C inhibitor 56, a powerful inhibitor of SOS1 with an inhibitory concentration (IC50) of 1.6 nM, holds promise for use in cancer research. |
|
T37422 |
Ras Inhibitory Peptide
|
|
|
|
Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to t... |
|
T8721 |
I-37
|
Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-6-(1-methylcyclopropyl)-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]- |
Raf
|
|
I-37 (Pyrido[4,3-d]pyrimidin-7(6H)-one, 2-methyl-6-(1-methylcyclopropyl)-4-[[(1R)-1-[2-methyl-3-(trifluoromethyl)phenyl]ethyl]amino]-) is a novel benzylamino substituted pyridopyrimidinone as SOS1 inhibitor. |
|
T63927 |
KRAS G12C inhibitor 25
|
|
|
|
KRAS G12C inhibitor 25 is an inhibitor of KRAS G12C. KRAS G12C inhibitor 25 inhibits the SOS1-assisted GDP/GTP exchange activity of KRAS-G12C mutants with an IC50 value of 0.48 nM. |
|
T69195 |
UC-857993
|
|
|
|
UC-857993, a selective SOS1-Ras inhibitor (Kd=14.7 μM, His6-SOS1cat), effectively suppresses catalytic activity. In addition to inhibiting ERK and Ras activation, it also hampers the growth of mouse embryonic fibroblasts... |
