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MAPK

A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase). MAPKs are involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. They regulate cell functions including proliferation, gene expression, differentiation, mitosis, cell survival, and apoptosis.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T63119 NF-κB/MAPK-IN-1 2413940-56-2 98%
NF-κB/MAPK-IN-1 is a potent dual inhibitor of the NF-κB and MAPK pathways with potential anti-inflammatory activity, inhibition of NO production, and inhibition ...
T16432 Pan-RAS-IN-1 1835283-94-7 98%
Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their effectors.
T36680 SM1-71 2088179-99-9 98%
SM1-71 is a potent multi-targeted acrylamide-modified TAK1 inhibitor that inhibits MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3,...
T8152 6-Demethoxytangeretin 6601-66-7 98%
6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa.
T14072 A-443654 552325-16-3 98%
A-443654 is a pan-Akt inhibitor. A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
T3672 Nomilin 1063-77-0 98%
Nomilin is naturally occurring triterpenoids, have immunomodulatory activity.
T21547 PAF (C16) 74389-68-7 98%
PAF (C16) is a potent MAPK and MEK/ERK activator that induces increased vascular permeability. PAF (C16) (PAF (C16)) is a platelet-activating factor, a phospholi...
T4264 Takinib 1111556-37-6 98%
Takinib (EDHS-206) is a specific and effective TAK1 inhibitor(IC50= 9.5 nM).
T3350 Selonsertib 1448428-04-3 98%
Selonsertib (GS-4997) is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and an...
TN1711 Gossypetin 489-35-0 98%
Gossypetin, a hexahydroxylated flavonoid extractable from Rhodiola rosea Linn. is a potent MKK3 and MKK6 inhibitor that strongly attenuates the MKK3/6-p38 signal...
TQ0079 GNE-495 1449277-10-4 98%
GNE-495 is a potent and specific MAP4K4 inhibitor (IC50: 3.7 nM).
T39321 CC-99677 1887069-10-4 98%
CC-99677 (Gamcemetinib) is a selectively targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune diseases that translates biochemical potency into cellular pot...
T7283 Sodium lauroyl-α-hydroxyethyl sulfonate T7283
Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.
T12979 BI-3406 2230836-55-0 100%
BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.
T8843 APS6-45 2188236-41-9 100%
APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.
TN4114 Gardenin A 21187-73-5 95.15%
Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.
T9880 ZINC05007751 591239-68-8 97.12%
ZINC05007751 is an effective inhibitor of NIMA-related kinase NEK6 (IC50 = 3.4 μM). ZINC05007751 is very selective against NEK1 and NEK6 with no significant acti...
T3101 NQDI-1 175026-96-7 97.19%
NQDI-1 (NQDI 1) is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50/Ki: 3 μM/500 nM).
T40350 HPK1-IN-4 2739844-28-9 97.2%
HPK1-IN-4 is an HPK1 (MAPK41) inhibitor with an IC 50 of 0.061 nM. HPK1-IN-4 is often used as a preclinical immunotherapy tool compound.
T60012 HS-243 848249-10-5 97.34%
HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.
NF-κB/MAPK-IN-1
T63119
NF-κB/MAPK-IN-1 is a potent dual inhibitor of the NF-κB and MAPK pathways with potential anti-inflammatory activity, inhibition of NO production, and inhibition ...
Pan-RAS-IN-1
T16432
Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their effectors.
SM1-71
T36680
SM1-71 is a potent multi-targeted acrylamide-modified TAK1 inhibitor that inhibits MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3,...
6-Demethoxytangeretin
T8152
6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa.
A-443654
T14072
A-443654 is a pan-Akt inhibitor. A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
Nomilin
T3672
Nomilin is naturally occurring triterpenoids, have immunomodulatory activity.
PAF (C16)
T21547
PAF (C16) is a potent MAPK and MEK/ERK activator that induces increased vascular permeability. PAF (C16) (PAF (C16)) is a platelet-activating factor, a phospholi...
Takinib
T4264
Takinib (EDHS-206) is a specific and effective TAK1 inhibitor(IC50= 9.5 nM).
Selonsertib
T3350
Selonsertib (GS-4997) is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and an...
Gossypetin
TN1711
Gossypetin, a hexahydroxylated flavonoid extractable from Rhodiola rosea Linn. is a potent MKK3 and MKK6 inhibitor that strongly attenuates the MKK3/6-p38 signal...
GNE-495
TQ0079
GNE-495 is a potent and specific MAP4K4 inhibitor (IC50: 3.7 nM).
CC-99677
T39321
CC-99677 (Gamcemetinib) is a selectively targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune diseases that translates biochemical potency into cellular pot...
sodium lauroyl-α-hydroxyethyl sulfonate
T7283
Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.
BI-3406
T12979
BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.
APS6-45
T8843
APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.
Gardenin A
TN4114
Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.
ZINC05007751
T9880
ZINC05007751 is an effective inhibitor of NIMA-related kinase NEK6 (IC50 = 3.4 μM). ZINC05007751 is very selective against NEK1 and NEK6 with no significant acti...
NQDI-1
T3101
NQDI-1 (NQDI 1) is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50/Ki: 3 μM/500 nM).
HPK1-IN-4
T40350
HPK1-IN-4 is an HPK1 (MAPK41) inhibitor with an IC 50 of 0.061 nM. HPK1-IN-4 is often used as a preclinical immunotherapy tool compound.
HS-243
T60012
HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.
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