|
T19595 |
UDP-glucuronic acid trisodium
|
UDP-glucuronic acid trisodium |
Others
|
|
UDP-glucuronic acid trisodium (UDP-glucuronic acid trisodium) is an indispensable precursor for vital glycoconjugates in various biological domains. These glycoconjugates encompass mammalian glycosaminoglycans, plant cel... |
|
T19596 |
UDP-GlcNAc Disodium Salt
|
Uridine 5′-diphospho-N-acetylglucosamine,UDP-α-D-N-Acetylglucosamine Disodium Salt |
Others
|
|
UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) is a nucleotide sugar. It is synthesized from glucose via the hexosamine biosynthetic pathway (HBP). |
|
T9369L |
UDP-a-D-Galactose disodium salt
|
|
Others
|
|
UDP-a-D-Galactose disodium salt is a donor substrate for galactosyltransferases employed in the biosynthesis of galactose-containing oligosaccharides[1]. |
|
T37900 |
UDP-Glucuronic Acid (sodium salt hydrate)
|
|
|
|
UDP-Glucuronic acid is a nucleoside diphosphate sugar that is a source of glucuronic acid for polysaccharide biosynthesis. This compound can be used for the formation of many glucuronides with various aglycones.1
1.Green... |
|
T37899 |
UDP-β-D-Glucose (sodium salt)
|
|
|
|
UDP-β-D-Glucose is the stereoisomer of UDP-α-D-glucose (sodium salt) . The activities of the UDP-β-D-glucose isomer are not known. |
|
T37898 |
UDP-α-D-Glucose (sodium salt hydrate)
|
|
|
|
UDP-α-D-Glucose is an endogenous nucleotide sugar involved in glycosyltransferase reactions in metabolism. It has been shown to bind the P2Y14receptor (EC50= 0.35 μM), an atypical P2Y receptor involved in the activation ... |
|
T22525 |
5-OMe-UDP trisodium salt
|
|
Others
|
|
Potent P2Y6 agonist |
|
T37901 |
UDP-N-acetyl-D-Glucosamine (sodium salt hydrate)
|
|
|
|
UDP-N-acetyl-D-Glucosamine is a natural nucleotide sugar that is used by glycosyltransferases to transfer N-acetyl-D-glucosamine residues to substrates.1It is an important component of antibiotic biosynthesis pathways in... |
|
T73809 |
UDP-GalNAc disodium
|
|
|
|
UDP-GalNAc (UDP-N-acetyl-D-galactosamine) disodium, a sugar nucleotide, serves as a substrate for EpsC115, an exopolymeric substances (EPS) N-terminal deletion mutant characterized by the absence of residues 1-115. Addit... |
|
T75579 |
UDP-xylose disodium
|
|
|
|
UDP-xylose disodium is a nature product that could be isolated from Cryptococcus laurentii (N RRL Y-1401). UDP-xylose disodium is a metabolite in the nucleotide sugar metabolism [1] . |
|
T74160 |
UDP-glucosamine disodium
|
|
|
|
UDP-glucosamine (UDP-GlcNAc) disodium serves as a substrate for O-GlcNAc transferase, facilitating the addition of O-GlcNAc to proteins, while its removal is catalyzed by O-GlcNAcase. This compound also represents the cu... |
|
T75398 |
UDP-sugar pyrophosphorylase (BlUSP)
|
|
|
|
UDP-sugar pyrophosphorylase (BlUSP) is an enzyme that activates glucose-1-phosphate (Glc-1-P) to UDP-glucose (UDP-Glc) and catalyzes the reversible transfer of the uridyl group from UTP to sugar-1-phosphate, resulting in... |
|
T83803 |
UDP-β-S sodium
|
Uridine-5' O-(2-thiodiphosphate) |
|
|
UDP-β-S, serving as a specific agonist for the purinergic P2Y6 receptor, effectively promotes inositol phosphate accumulation in 1321N1 cells containing P2Y6 receptors, with an EC50 value of 28 nM. This selectivity is ev... |
|
T83839 |
Uridine 5'-methylenediphosphate sodium
|
α,β-methylene UDP,UMP-CP |
|
|
Uridine 5’-methylenediphosphate (UMP-CP), a hydrolytically stable derivative of UDP and agonist of the purinergic P2Y14 receptor, exhibits selective inhibition of cAMP production in cells expressing human P2Y14 compared ... |
|
T9054 |
RO6889678
|
|
HBV
|
|
RO6889678 is HBV inhibitor with a complex ADME profile. |
|
T65012 |
Bis(4-nitrophenyl) phosphate
|
BNPP |
Others
|
|
Bis(4-nitrophenyl) phosphate (BNPP) inhibits UDP-galactose and can be used to study glycosyltransferase membrane topology. |
|
T10851 |
CMP-Sialic acid sodium salt
|
CMP-Neu5Ac sodium salt |
Others
|
|
CMP-Sialic acid sodium salt is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. It provides a substrate for Golgi sialyltransferases. UDP-GlcNAc 2-epimerase initiates sialic acid synthesis. |
|
T11876 |
LpxH-IN-AZ1
|
|
Antibacterial
|
|
|
|
T41275 |
PF-04753299
|
|
Others
|
|
PF-04753299 is a potent and selective inhibitor of UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase (LpxC), demonstrating bactericidal effects against gonococcal isolates. It exhibits inhibitory activity aga... |
|
T73899 |
Uridine diphosphate glucuronic acid ammonium
|
|
|
|
Uridine diphosphate glucuronic acid (UDP-GlcA) ammonium, formed through the enzymatic action of UDP-glucose dehydrogenase, serves as a crucial cofactor in sugar nucleotide biosynthesis. It acts as a pivotal precursor and... |
|
T75397 |
Hyaluronan synthase (PmHAS)
|
|
|
|
Hyaluronan synthase (PmHAS), a membrane protein, catalyzes the biosynthesis of hyaluronic acid (HA) by utilizing only Mg+2 along with two sugar-UDP substrates, GlcUA-UDP and GlcNAc-UDP, to polymerize HA chains [1] [2]. |
|
T71215 |
Faldaprevir sodium
|
|
|
|
Faldaprevir sodium is a potent NS3/NS4A protease inhibitor potentially for the treatment of HCV infection. Faldaprevir is known to inhibit P-glycoprotein, CYP3A4, and UDP-glucuronosyltransferase 1A1. |
|
T11715 |
JH-LPH-28
|
|
Others
|
|
JH-LPH-28, a sulfonyl piperazine analog, is a potent inhibitor of UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH, exhibiting exceptional antibiotic activity with a minimum inhibitory concentration (MIC) value of ... |
|
T19685 |
Faldaprevir
|
BI-201335,BI201335,BI 201335 |
|
|
Faldaprevir is an effective NS3/NS4A protease inhibitor potentially for the treatment of HCV infection. Faldaprevir is known to inhibit P-glycoprotein, CYP3A4, and UDP-glucuronosyltransferase 1A1. |
|
T39478 |
L-threo-PPMP
|
|
|
|
L-threo-PPMP is an inhibitor of GlcT, which is the UDP-Glc: Ceramide β1,1glucosyltransferase enzyme. It effectively inhibits glycosphingolipid biosynthesis, while also inducing apoptosis. These properties of L-threo-PPMP... |
|
T68827 |
MRS2690
|
|
|
|
MRS2690 is a potent P2Y14 receptor agonist (EC50 = 49 nM) that displays 7-fold higher potency than UDP-glucose. |
|
T37117 |
Etodolac Acyl Glucuronide
|
|
|
|
Etodolac acyl glucuronide is a phase II metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor etodolac .1It is formedviaglucuronidation of etodolac by the UDP-glucuronosyltransferase (UGT) isof... |
|
T73747 |
CMP-Sialic acid
|
|
|
|
CMP-Sialic acid (CMP-Neu5Ac) serves as an allosteric inhibitor of UDP-GlcNAc 2-epimerase, a substrate for Golgi sialyltransferases, and is crucial for the biosynthesis of sialic acid and its conjugates [1]. |
|
T75399 |
GlcNAc 1-P uridyltransferase (CjGlmU)
|
|
|
|
GlcNAc 1-P uridyltransferase (CjGlmU), a sugar nucleotidyltransferase (SNT), employs UTP and GlcNAc-1-P to synthesize UDP-GlcNAc, with potential implications in antimicrobial agent research [1]. |
|
T11716 |
JH-LPH-33
|
|
Others
|
|
JH-LPH-33, a sulfonyl piperazine analog, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. It exhibits remarkable antibiotic activity, reflected by a minimal inhibitory concentration (MIC) val... |
|
T75413 |
Beta-1,4-Galactosyltransferase (LgtB)
|
|
|
|
Beta-1,4-Galactosyltransferase (LgtB) (B4GALT1(LgtB)), a key enzyme in biochemical research, catalyzes the transfer of UDP-galactose to N-acetylglucosamine, resulting in the synthesis of galactose beta-1,4-N-acetylglucos... |
|
T72129 |
D,L-erythro-PDMP hydrochloride
|
|
|
|
D,L-erythro-PDMP hydrochloride, an erythro isomer of PDMP, inhibits the growth of cultured rabbit skin fibroblasts and serves as an effective inhibitor of UDP-glucose:ceramide glucosyltransferase. |
|
T35952 |
All-trans Retinoyl β-D-Glucuronide
|
|
|
|
all-trans Retinoyl β-D-glucuronide is a metabolite of all-trans retinoic acid formed by the UDP-glucuronosyltransferase (UGT) system. It is rapidly converted to all-trans retinoic acid following in vitro or in vivo admin... |
|
T62624 |
LpxA-IN-1
|
|
|
|
LpxA-IN-1, a novel UDP-N-acetylglucosamine acyltransferase (LpxA) inhibitor exhibiting potent activity (IC 50 2 nM), effectively targets Pseudomonas aeruginosa with a minimum inhibitory concentration (MIC) of 8 μg/mL. |
|
T38489 |
D,L-erythro-PDMP
|
|
|
|
D,L-erythro-PDMP, an erythro isomer of PDMP, exhibits growth inhibition on cultured rabbit skin fibroblasts. Additionally, this compound serves as an effective inhibitor of UDP-glucose: ceramide glucosyltransferase. |
|
T37852 |
Chlorzoxazone N-Glucuronide
|
|
|
|
Chlorzoxazone N-glucuronide is a phase II metabolite of the skeletal muscle relaxant chlorzoxazone . Chlorzoxazone N-glucuronide is formed via glucuronidation of chlorzoxazone by the UDP-glucuronosyltransferase (UGT) iso... |
|
T36300 |
Uridine-5’-monophosphate (sodium salt hydrate)
|
|
|
|
Uridine-5’-monophosphate (UMP) is a ribonucleotide.1It is formedviadecarboxylation of orotidine-5’-monophosphate (5’-OMP) by OMP decarboxylase. UMP is further phosphorylated by UMP-CMP kinase to form UDP and UTP during n... |
|
T36826 |
Acetaminophen Glucuronide (sodium salt)
|
|
|
|
Acetaminophen glucuronide is an inactive metabolite of the analgesic and antipyretic agent acetaminophen . It is formed via glucuronidation of acetaminophen by the UDP-glucuronosyltransferase (UGT) isoforms UGT1A6, UGT1A... |
|
T37484 |
1-Salicylate Glucuronide
|
|
|
|
1-Salicylate glucuronide is a metabolite of salicylic acid and aspirin .1It is formed from salicylic acid primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT1A9 but also by a variety of other UGT isoforms and ... |
|
T35845 |
(R,S)-Carvedilol Glucuronide
|
|
|
|
(R,S)-Carvedilol glucuronide is a racemic mixture of the carvedilol metabolites (R)-carvedilol glucuronide and (S)-carvedilol glucuronide. (R)-Carvedilol glucuronide is formed via glucuronidation of (R)-carvedilol by the... |
|
T61998 |
UGM-IN-3
|
|
|
|
UGM-IN-3 (compound 10a) is a inhibitor of UDP-galactopyranose mutase (UGM) with a Kd of 66 μM. UGM-IN-3 inhibits the growth of Mycobacterium tuberculosis (MIC= 6.2 μg/mL). |
|
T75418 |
Alpha-1,3-Galactosyltransferase (GTB)
|
|
|
|
Alpha-1,3-Galactosyltransferase (GTB) (alpha 1,3GT) is responsible for catalyzing the synthesis of the α-galactose (α-Gal) epitope, known as a xenoantigen. This enzyme facilitates the transfer of galactose from UDP-Gal t... |
|
T75411 |
Beta-1, 3-N-Acetylhexaminyltransferase (LgtA)
|
|
|
|
Beta-1, 3-N-Acetylhexaminyltransferase (LgtA), a glycosyltransferase, plays a critical role in biochemical studies by catalyzing the transfer of N-acetylglucosamine from UDP-GlcNAc to substrates including N-acetyllactosa... |
|
T36071 |
Silodosin Glucuronide (sodium salt)
|
|
|
|
Silodosin glucuronide is an active metabolite of the α1A-adrenergic receptor antagonist silodosin . It is formed from silodosin by the UDP-glucuronosyltransferase (UGT) isoform UGT2B7. Silodosin glucuronide is toxic to r... |
|
T75417 |
Alpha-1,3-Galactosyltransferase (a1,3GalT)
|
|
|
|
Alpha-1,3-Galactosyltransferase (a1,3GalT) (GGTA1) catalyzes the synthesis of the α-gal epitope by transferring a galactose (Gal) molecule in an α1-3 linkage from a uridyl-diphosphate (UDP) donor to the N-acetyllactosami... |
|
T78352 |
N-acetylglucosamine-1-P uridyltransferase (AGX1)
|
GlcNAc1pUT |
|
|
N-acetylglucosamine-1-P uridyltransferase (AGX1) (GlcNAc1pUT) is a bifunctional enzyme that couples with GlcNAc-1-P and UTP to catalyze the synthesis of UDP-GlcNAc through an uridyltransfer reaction. It exhibits acetyltr... |
|
T83873 |
Dabigatran Acyl-β-D-Glucuronide TFA
|
Dabigatran β-1-O-Acyl Glucuronide |
|
|
Dabigatran acyl-β-D-glucuronide, an active metabolite of the thrombin inhibitor dabigatran, is synthesized predominantly through the action of the UDP-glucuronosyltransferase isoform UGT2B15. This compound, at a concentr... |
|
T39790 |
LpxC-IN-5
|
|
|
|
LpxC-IN-5 is a potent, non-hydroxamate inhibitor of LpxC, which is an enzyme known as UDP-3-O-acyl-N-acetylglucosamine deacetylase. It exhibits an IC50 value of 20 nM. Furthermore, LpxC-IN-5 displays antibacterial activi... |
|
T35939 |
Dabigatran Acyl-β-D-Glucuronide
|
|
|
|
Dabigatran acyl-β-D-glucuronide is a major active metabolite of the thrombin inhibitor dabigatran . The prodrug of dabigatran, dabigatran etexilate , is hydrolyzed by plasma esterases to form dabigatran, which is metabol... |
|
T62664 |
Glucosylceramide synthase-IN-2
|
|
|
|
Glucosylceramide synthase-IN-2 (compound T-690) is a potent, blood-brain barrier-permeable, orally active inhibitor of glucosylceramide synthase (GCS) that acts on human GCS (IC50: 15 nM) and mouse GCS (IC50: 190 nM). Gl... |
