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Search Results for " cell-penetration "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T2354	UNC 0631	UNC0631	Histone Methyltransferase
	UNC 0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM).		Histone Methyltransferase
TQ0232	UNC0646	UNC 0646	Histone Methyltransferase
	UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646(UNC 0646) potently blocks G9a/GLP methyltransferase activity in cells ...		Histone Methyltransferase
TP2505L	LAH4 acetate	KKALLALALHHLAHLALHLALALKKA acetate,LAH4 acetate(184776-51-0 Free base)	Antibacterial
	LAH4 acetate is the α-helical structure of the designed amphoteric peptide antibiotic, which is capable of complexing DNA, associating with the cell surface membrane and wrapped in the endosome, which is destroyed with t...		Antibacterial
T11797	L-690488		Others
	L-690488 has more effective cell penetration than L-690330. L-690488 is a prodrug of L-690330 and is a selective inositol monophosphatase (IMPase) inhibitor.		Others
T61701	SHP2-IN-9
	SHP2-IN-9 is a potent inhibitor (IC50 = 1.174 μM) specifically targeting the SHP2 protein, displaying improved penetration across the blood-brain barrier. It exhibits a remarkable 85-fold selectivity for SHP2 over SHP1. ...
T60970	Caprochlorone
	Caprochlorone exhibits antiviral activity against orthopoxvirus that decreases the influenza virus titers in infected-mice lungs. Caprochlorone can inhibit cell penetration by virus as well as delays newly formed virus r...
T17454	ATP-polyamine-biotin		Others
	ATP-polyamine-biotin is a cell-permeable, efficient kinase cosubstrate with conversions and kinetics similar to those of other known ATP analogues. APB shows a cytotoxicity EC50 value of 19 ± 1 mM. ATP-polyamine-biotin i...		Others
T75762	LAH4 TFA
	LAH4 TFA, an alpha-helix of the designed amphipathic peptide antibiotic, demonstrates potent antimicrobial, nucleic acid transfection, and cell penetration capabilities, alongside high plasmid DNA delivery capacities. It...
T68547	SNJ-1945
	SNJ-1945 is a calpain inhibitor with more favorable retinal penetration, high oral bioavailability, and long half-life. SNJ1945 rescued defective function in lissencephaly. SNJ-1945 protects SH-SY5Y cells against MPP(+) ...
T61388	HAChE/Aβ1-42-IN-1
	Compound 16 (hAChE/Aβ1-42-IN-1) is a potent inhibitor targeting both hAChE and Aβ1-42 aggregation, demonstrating considerable safety in hepG2 cell lines and excellent brain-blood barrier (BBB) penetration with a broad sa...
T81526	Pegsebrenatide	NLY01
	Pegsebrenatide (NLY01), a long-acting GLP-1R agonist, exhibits an extended half-life and favorable blood-brain barrier penetration. It impedes A1 astrocyte transformation, mitigates dopaminergic cell death, and ameliorat...
T71577	KOS-1584
	KOS-1584 is a second-generation epothilone with potential antineoplastic activity. Epothilone KOS-1584 binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which m...
T82010	JDB175		BTK
	JDB175, a selective BTK inhibitor with oral bioavailability, demonstrates excellent penetration through the blood-brain barrier. It exhibits potent activity against central nervous system lymphoma in a mouse model, with ...		BTK
T68860	Iso-Fludelone
	Iso-Fludelone is the third-generation epothilone B analogue with potential anti-mitotic and antineoplastic activites. Iso-fludelone binds to tubulin and induces microtubule polymerization and stabilizes microtubules agai...

Compounds

UNC 0631

T2354

Synonym: UNC0631

Target: Histone Methyltransferase

UNC0646

TQ0232

Synonym: UNC 0646

Target: Histone Methyltransferase

LAH4 acetate

TP2505L

Synonym: KKALLALALHHLAHLALHLALALKKA acetate,LAH4 acetate(184776-51-0 Free base)

Target: Antibacterial

カタログ番号	製品名	別名	ターゲット
T4820	Maleimide	2,5-Pyrroledione	Others
	Maleimide (2,5-Pyrroledione) (2,5-Pyrroledone) is a new nanoparticle surface functional group which favors easy conjugation with cell penetration peptides. The conjugation is enabled via click chemistry to preserve its b...		Others
T3229	Cytochalasin D		ATPase , p38 MAPK , Calcium Channel , Akt , PI3K
	Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head dec...		ATPase , p38 MAPK , Calcium Channel , Akt , PI3K

天然物製品

Maleimide

T4820

Synonym: 2,5-Pyrroledione

Target: ATPase, p38 MAPK, Calcium Channel, Akt, PI3K

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-01813	ACRV1 Protein, Human, Recombinant (His)	Human	HEK293
	Acrosomal protein SP-1, also known as Acrosomal vesicle protein 1 and ACRV1, is a testis-specific, differentiation antigen, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the a...
TMPH-00521	G3P Protein, Enterobacteria phage M13, Recombinant (His)	Enterobacteria phage M13	Yeast
	Plays essential roles both in the penetration of the viral genome into the bacterial host via pilus retraction and in the extrusion process. During the initial step of infection, G3P mediates adsorption of the phage to i...
TMPH-00674	OmpA Protein, E. coli O157:H7, Recombinant (His & SUMO)	E. coli	E. coli
	With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows dow...
TMPH-00782	OMP P5 Protein, Haemophilus influenzae, Recombinant (His & Myc & SUMO)	Haemophilus influenzae	E. coli
	Acts as a fimbriae subunit, allowing adhesion to host cells.; With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows...
TMPH-02377	OmpA Protein, Klebsiella pneumoniae, Recombinant (His & Myc)	Klebsiella pneumoniae	E. coli
	With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows dow...
TMPH-03472	OmpA Protein, Salmonella typhi, Recombinant (His)	Salmonella typhi	E. coli
	With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows dow...
TMPH-03426	Rotavirus X (isolate novel adult diarrhea rotavirus-B219) VP4 Protein (His)	RVX	Yeast
	Spike-forming protein that mediates virion attachment to the host epithelial cell receptors and plays a major role in cell penetration, determination of host range restriction and virulence. Rotavirus attachment and entr...
TMPH-03425	Rotavirus A (strain St. Thomas 3) VP4 Protein (His)	RV-A	Yeast
	Spike-forming protein that mediates virion attachment to the host epithelial cell receptors and plays a major role in cell penetration, determination of host range restriction and virulence. Rotavirus attachment and entr...
TMPH-03424	Rotavirus A (strain Nebraska calf diarrhea virus) VP4 Protein (His & Myc)	RV-A	E. coli
	Spike-forming protein that mediates virion attachment to the host epithelial cell receptors and plays a major role in cell penetration, determination of host range restriction and virulence. Rotavirus attachment and entr...
TMPH-02345	Influenza A H1N1 (train A/Hickox/1940) Hemagglutinin/HA Protein (His & SUMO)	H1N1	E. coli
	Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis...
TMPH-00698	OmpA Protein, E. coli, Recombinant (His)	E. coli	in vitro E. coli expression system
	With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm (Probable). Plays a role in resistance to environmental stress, and a role in outer membrane functionality and c...