PI3K

Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.PI3Ks are a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns). The pathway, with oncogene PIK3CA and tumor suppressor PTEN, is implicated in the sensitivity of cancer tumors to insulin and IGF1, and in calorie restriction.

Cat. No.	製品名	CAS No.	Purity
TN2259	Taurocholic acid	81-24-3	98%
TN2259	Taurocholic acid is a bile acid involved in the emulsification of fats.Taurocholic acid is cytoprotective, preventing tumor necrosis factor-alpha-induced cholang...
T3P2904	α-Linolenic acid	463-40-1	98%
T3P2904	Linolenic Acid is an essential fatty acid belonging to the omega-3 fatty acids group. It is highly concentrated in certain plant oils and has been reported to in...
TN2019	Orobol	480-23-9	98%
TN2019	Orobol is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover. Orobol inhibits PI3K isoforms with IC50s of 3.46-5.27 μM for PI3K α...
T2S1040	Jolkinolide B	37905-08-1	98%
T2S1040	Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
T2265	Bimiralisib	1225037-39-7	98%
T2265	PI3K-IN-2 is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity. PI3K-IN-2 inhibits the PI3K kinase i...
T36083	DS-7423	1222104-37-1	98%
T36083	DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR, respectively. DS-7423 possesses anti-tumor activity[1][2]. DS...
T39573	GSK251	2125968-05-8	98%
T39573	GSK251 is a novel, orally bioavailable inhibitor of PI3Kδ, exhibiting high potency and selectivity, with a unique binding mode.
TN1134	Euscaphic acid	53155-25-2	98%
TN1134	Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 w...
T8651	CAL-101	1146702-54-6	98%
T8651	CAL-101 is a selective inhibitor of p110δ(IC50 : 2.5 nM; in cell-free assays); shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 40...
T5818	Rigosertib sodium	592542-60-4	98%
T5818	Rigosertib, a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.
T61618	PI3K-IN-38	1382979-64-7	98%
T61618	PI3K-IN-38 is an orally available and potent PI3K inhibitor with an IC50 value of 0.541 µM for PI3K-α. PI3K-IN-38 exhibits anticancer and anti-inflammatory activ...
T11129	Duvelisib (R enantiomer)	1261590-48-0	98%
T11129	Duvelisib R enantiomer is an enantiomer with low activity of Duvelisib and is an inhibitor of PI3K.
T4867	Erucic acid	112-86-7	98%
T4867	Increased levels of erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression (PMID: 16581239 ). Er...
T9788	SN32976	1246202-11-8	98%
T9788	SN32976 is a pan PI3K inhibitor. SN32976 potently inhibited PI3K isoforms and mTOR, displaying preferential activity for PI3Kα and sparing of PI3Kδ.
T13386	Zandelisib	1401436-95-0	98%
T13386	Zandelisib is an inhibitor of phosphatidylinositol 3-kinase (PI3K)(p110δ, IC50 of 3.5 nM), and with antineoplastic activity.
T26252	PI3Kδ-IN-3	1431540-99-6	98%
T26252	PI3Kδ-IN-3 is a PI3Kδ inhibitor with an IC50 value of 9 nM.PI3Kδ-IN-3 has a favorable pharmacokinetic profile and inhibits B cell function.
TQ0003L1	740 Y-P acetate	TQ0003L1	98%
TQ0003L1	740 Y-P acetate is a potent and cell-permeable PI3K activator.740 Y-P acetate tends to bind to GST fusion proteins containing the N- and C-terminal SH2 structura...
T2083	PI-3065	955977-50-1	98%
T2083	PI-3065 is a novel potent and selective PI3K p110δ inhibitor.
T1827	Buparlisib	944396-07-0	98%
T1827	Buparlisib is an orally bioavailable specific oral inhibitor of the pan-class I PI3K (IC50s: 52/166/116/nM for p110α, p110β, and p110δ).
TN2063	Physalin B	23133-56-4	98%
TN2063	Physalin B is one of the major active compounds from the Solanaceae family of plants and has a wide range of biological activities for the treatment of inflammat...