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天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T4573	Cyclothiazide		GluR
	Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its response to glutamic acid (EC50 = 3.8 M).		GluR
T14989	CMPD101		ROCK , GRK , PKC
	CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM). Which can be used for the study of heart failure. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKCα with I...		ROCK , GRK , PKC
T4236	AR-M 1000390 hydrochloride	ARM390 Hydrochloride,ARM-390 HCl	Opioid Receptor
	AR-M 1000390 hydrochloride (ARM-390 HCl) , also known as ARM-390, is a low-internalizing nonpeptidic δ-selective opioid receptor agonist; derivative of SNC 80. Does not trigger acute desensitization of the analgesic resp...		Opioid Receptor
T27806	Lecozotan HCl	SRA-333,SRA333,SRA 333,Lecozotan hydrochloride	5-HT Receptor
	Lecozotan HCl (SRA-333) is a potent and selective 5-HT antagonist that significantly enhances KCl-stimulated glutamate and acetylcholine release from the hippocampal dentate gyrus and has cognitive enhancing properties. ...		5-HT Receptor
T33289	Meproadifen
	Meproadifen enhances activation and desensitization of the acetylcholine receptor-ionic channel complex (AChR).
TP2058	Catestatin
	Non-competitive nicotinic cholinergic antagonist; selectively inhibits nicotinic-stimulated catecholamine secretion from chromaffin cells and noradrenergic neurons (IC50 ~ 200 nM). Blocks nicotinic-induced cationic signa...
T38392	JAMI1001A
	JAMI1001A is a positive allosteric modulator of the AMPA receptor, effectively modulating the deactivation and desensitization of both flip and flop receptor isoforms.
T36634	ZQ 16
	Selective medium-chain free fatty acid receptor GPR84 agonist (EC50 = 139 nM). Exhibits no response at GPR40, GPR41, GPR119 or GPR120 at 100 μM. Activates calcium mobilization, inhibits cAMP accumulation, and induces ERK...
T80503	Proadrenomedullin (N-20) (bovine, porcine)	ProADM N20(bovine, porcine),PAMP-20(bovine, porcine)
	Proadrenomedullin (N-20) (ProADM N20) (bovine, porcine) is a peptide known for its strong hypotensive effects and inhibition of catecholamine release from chromaffin cells without competing with other substances. It effe...
T76399	PKI(5-22)amide
	PKI(5-22)amide, an active inhibitory fragment of the cyclic AMP-dependent protein kinase (PKA) inhibitor, effectively prevents PKA activation. However, it does not reduce the homologous desensitization of CRF1 receptors ...
T72744	(R)-PF-06256142
	(R)-PF-06256142, the R enantiomer of PF-06256142, exhibits low activity. PF-06256142 itself is distinguished as a potent and selective orthosteric D1 receptor agonist, with the capability to minimize receptor desensitiza...
T71398	RO5126946
	RO5126946 is a Novel α7 nicotinic acetylcholine receptor-positive allosteric modulator. RO5126946 allosterically modulates α7nAChR activity. RO5126946 increased acetylcholine-evoked peak current and delayed current decay...

Compounds

Target: ROCK, GRK, PKC

AR-M 1000390 hydrochloride

T4236

Synonym: ARM390 Hydrochloride,ARM-390 HCl

Target: Opioid Receptor

Lecozotan HCl

T27806

Synonym: SRA-333,SRA333,SRA 333,Lecozotan hydrochloride

Target: 5-HT Receptor

Proadrenomedullin (N-20) (bovine, porcine)

T80503

Synonym: ProADM N20(bovine, porcine),PAMP-20(bovine, porcine)

カタログ番号	製品名	別名	ターゲット
TN5580	Rediocide A
	Rediocide A, an insecticide, can inhibit calcium mobilization in Drosophila G-protein- coupled receptors (GPCR)s other than methuselah, it can induce GPCR desensitization and internalization, and such effects are mediate...

天然物製品

Recombinant Proteins

Species：

Expression System：

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カタログ番号	製品名	Species	Expression System
TMPJ-00983	ARRB1 Protein, Human, Recombinant (His)	Human	E. coli
	β-Arrestin-1 (ARRB1) is a cytoplasmic protein that belongs to the arrestin family. ARRB1 is expressed at high levels in peripheral blood leukocytes and the central nervous system. ARRB1 regulates agonist-mediated G-prote...
TMPH-02267	AGTRAP Protein, Human, Recombinant (His & Myc & SUMO)	Human	in vitro E. coli expression system
	Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decr...
TMPH-02331	GLRA1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Channel characteristics depend on the subunit co...
TMPY-04555	GRK5 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	G protein-coupled receptor kinase 5, also known as G protein-coupled receptor kinase GRK5 and GRK5, is a member of the protein kinase superfamily, AGC Ser/Thr protein kinase family, and GPRK subfamily. GRKs specifically ...
TMPH-02540	GRK2 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to...
TMPH-01719	OPRM1 Protein, Human, Recombinant (His)	Human	in vitro E. coli expression system
	Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to th...
TMPJ-00715	FGF-19 Protein, Human, Recombinant (His)	Human	E. coli
	Fibroblast growth factor 19 (FGF19) is a secreted protein which belongs to the FGFs family. FGF19 is expressed in fetal brain, cartilage, retina, and adult gall bladder. FGFs modulate cellular activity via at least 5 dis...