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T62764 |
Estrogen receptor α antagonist 1
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Others
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Estrogen receptor α antagonist 1 (compound 35) is a highly selective estrogen receptor α antagonist that acts on estrogen receptor α (IC50: 0.02 μM), estrogen receptor β (IC50. Estrogen receptor α antagonist 1 (compound ... |
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T6306 |
Erteberel
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LY500307 |
Estrogen Receptor/ERR
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Estrogen/progestogen Receptor
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Erteberel (LY500307) is a potent, selective estrogen receptor β agonist with EC50 of 0.66 nM, 32-fold selectivity against estrogen receptor α. Phase 2. |
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T5835 |
PROTAC ERRα ligand 2
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Estrogen Receptor/ERR
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Estrogen/progestogen Receptor
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PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist( IC50 : 5.67 nM) |
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T15191 |
PROTAC ERRα ligand 1
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Estrogen Receptor/ERR
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Estrogen/progestogen Receptor
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PROTAC ERRα ligand 1 is an α (ERRα) antagonist of estrogen-related receptor (IC50s of 0.04 and 2.8 μM for ERRα and ERRγ, respectively). |
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T16566 |
Propyl pyrazole triol
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PPT |
Estrogen Receptor/ERR
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Estrogen/progestogen Receptor
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Propyl pyrazole triol (PPT) is a selective agonist of estrogen receptor alpha. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: ... |
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T11230 |
ERRα antagonist-1
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ERR+/- antagonist-1,ERRa antagonist-1 |
Estrogen/progestogen Receptor
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ERRα antagonist-1 (ERR+/- antagonist-1) is a high-affinity, selective antagonist of the estrogen-related receptor α (ERRα). It effectively prevents the interaction of ERRα with both Proliferator-activated Receptor γ Coac... |
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T13700 |
GDC-0927 Racemate
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SRN-927 Racemate |
Others
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GDC-0927 Racemate is a degrader of estrogen receptor, is used in the research of ER-related diseases, potently inhibits ER-α activity, with an IC50 of 0.2 nM. |
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T39368 |
GNE-149
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Others
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GNE-149 is an orally bioavailable compound that acts as a full antagonist of estrogen receptor α (ERα) with an IC50 of 0.053 nM. It is also classified as a selective estrogen receptor degrader (SERD). GNE-149 holds poten... |
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T79109 |
Estrogen receptor modulator 8
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Estrogen Receptor/ERR
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Estrogen Receptor Modulator 8 (compound 4) is an orally active inhibitor targeting Estrogen Receptor/ERR α with potent efficacy (IC50 = 0.437 nM in MCF-7 cells) and effectively hampers MCF-7 cell proliferation (IC50 = 0.... |
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T25367 |
EM-800
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EM800,EM 800 |
Others
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EM-800 is a high affinity ligand for estrogen receptor-α (ERα), the prodrug of EM-652. EM-800 independently inhibited the growth of E1-stimulated ZR-75-1 xenograft tumors in nude mice. |
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T62490 |
OBHS
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Others
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OBHS is an inhibitor of estrogen receptor alpha (ERα). |
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T63277 |
Estrogen receptor antagonist 2
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Others
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Estrogen receptor antagonist 2 is a selective down-regulator of estrogen receptor. Estrogen (E2) and estrogen alpha receptor (ERα) are important drivers of breast cancer development. estrogen receptor antagonist 2 has re... |
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T17940 |
Estrone-N-O-C1-amido
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ERα ligand 1 |
Others
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Estrone-N-O-C1-amido (ERα ligand 1) is an estrogen ligand derived from Estrone that specifically binds to estrogen receptor α (ERα). Through a linker, Estrone-N-O-C1-amido (ERα ligand 1) forms a complex with the cIAP1 li... |
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T63582 |
Estrogen receptor antagonist 1
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Others
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Estrogen receptor antagonist 1 is a potent antagonist of the estrogen receptor. Estrogen receptor antagonist 1 has shown research potential in breast cancer disease. |
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T22159 |
TCS HDAC6 20b
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Others
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TCS HDAC6 20b is a HDAC6 -selective inhibitor that blocks the growth of estrogen receptor α-positive breast cancer MCF-7 cells [1]. |
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T36913 |
17-Epiestriol
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Others
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17-Epiestriol is a metabolite of estrone .1It is formed from estroneviaa 16α-hydroxy estrone intermediate by reduction of the C-17 ketone. 17-Epiestriol binds to estrogen receptor α (ERα) and ERβ with relative binding af... |
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T79382 |
ER degrader 6
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Estrogen Receptor/ERR
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ER degrader 6 (compound 35s) is a potent selective estrogen receptor modulator (SERM) with the capacity to degrade Estrogen Receptor (ER)α. It disrupts the microtubule network, inhibiting tubulin polymerization, and effe... |
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T39298 |
Raloxifene 4-Monomethyl Ether
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Others
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Raloxifene 4-Monomethyl Ether (Compound 37) is a derivative of Raloxifene which acts as an inhibitor of estrogen receptor α. It effectively suppresses the activity of MCF-7 cells, exhibiting an IC50 value of 1 μM and a p... |
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T39203 |
Raloxifene 6-Monomethyl Ether
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Others
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Compound 7, or Raloxifene 6-Monomethyl Ether, is a derivative of Raloxifene that effectively inhibits estrogen receptor α. It also displays the inhibitory effects on MCF-7 cells, with an IC50 of 250 nM and a pIC50 of 6.6... |
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T40349 |
DS45500853
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Others
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DS45500853, an estrogen-related receptor α (ERRα) agonist, acts as an inhibitor of the binding interaction between receptor-interacting protein 140 (RIP140) corepressor peptide (10 nM) and GST-ERRα ligand-binding domain ... |
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T39838 |
(S,R,S)-AHPC-C7-amine
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VH032-C7-amine,(S,R,S)-AHPC-C7-amine |
Others
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(S,R,S)-AHPC-C7-amine, also known as VH032-C7-amine, is a chemically synthesized conjugate that functions as an E3 ligase ligand-linker. This compound combines the VH032-based VHL ligand with a specific linker designed f... |
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T61923 |
ERRα antagonist-2
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Others
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ERRα antagonist-2 (Compound 11) is a potential Reverse agonist of ERR α (estrogen receptor related receptor α) (IC50=0.80 μ M). ERRα antagonist-2 can inhibit the migration and invasion of ER-negative MDA-MB-231 cells. ER... |
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T39651 |
(S,R,S)-AHPC-C5-NH2
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(S,R,S)-AHPC-C5-NH2,VH032-C5-NH2 |
Others
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(S,R,S)-AHPC-C5-NH2, also known as VH032-C5-NH2, is a synthetic compound designed as an E3 ligase ligand-linker conjugate. This compound combines the VH032-based von Hippel-Lindau (VHL) ligand with a linker, enabling it ... |
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T18605 |
PROTAC ERα Degrader-2
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Others
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PROTACs
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PROTAC ERα Degrader-2 is composed of a cIAP1 ligand binding group, a linker, and an estrogen receptor α (ERα) binding group, serving as an ERα degrader. It achieves maximal ERα degradation in human mammary tumor MCF7 cel... |
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T83907 |
10-Chloroestra-1,4-diene-3,17-dione
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10-chloro-1,4-Estradiene |
Others
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10-Chloroestra-1,4-diene-3,17-dione acts as an estrogen receptor α (ERα) agonist, enhancing reporter gene expression in S. cerevisiae with an EC50 of 0.36 nM for the human receptor. Additionally, it functions as an aroma... |
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T60827 |
TPBM
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Others
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TPBM is a potent inhibitor of estrogen receptor α (ERα). The IC 50 value of TPBM for 17β-estradiol (E2)-ERα is 9 μM. TPBM is not toxic to cells and reduces E2·ERα recruitment to an endogenous estrogen-responsive gene. TP... |
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T60441 |
DK3
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Others
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DK3 is a potent and selective agonist of estrogen-related receptor alpha (ERRα). ERRα is a potential drug target for cancer and metabolic diseases [1]. |
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T60759 |
DS20362725
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Others
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DS20362725 is an agonist of estrogen-related receptor α (ERRα) that is able to be used for the metabolic disorders research, for example, type 2 diabetes mellitus (T2DM). The IC 50 value of DS20362725 inhibiting the bind... |
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T18697 |
SNIPER(ER)-87
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Others
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SNIPER(ER)-87 is a chemical compound composed of a derivative of the inhibitor of apoptosis protein (IAP) ligand LCL161 conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen using a PEG linker. It effecti... |
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T74375 |
PROTAC ERα Y537S degrader-1
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Others
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PROTAC ERα Y537S degrader-1 comprises a ubiquitin E3 ligase binding group, a linker and a protein binding group. PROTAC ERα Y537S degrader-1 is an estrogen receptor-alpha (ERα) Y537S degrader [1] . |
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T64026 |
ERα antagonist 1
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Others
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ERα antagonist 1 is a selective, potent, covalent estrogen receptor alpha (ERα) antagonist that blocks the cell cycle of MCF-7 cells in G0/G1 phase and induces apoptosis. |
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T74060 |
AZ'6421
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Others
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AZ'6421, functioning as a Proteolysis Targeting Chimera (PROTAC), selectively degrades estrogen receptor alpha, demonstrating potent anti-tumor activity by inhibiting uncontrolled cellular proliferation characteristic of... |
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T62106 |
(Rac)-ErSO-DFP
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Others
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(Rac)-ErSO-DFP is a derivative of ErSO-DFP and a selective small molecule Erα biomodulator. (Rac)-ErSO-DFP overactivates ERα+-dependent anticipatory unfolded protein responses and exhibits anti-estrogen receptor alpha-po... |
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T35676 |
17β-hydroxy Exemestane
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Others
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17β-hydroxy Exemestane is the primary active metabolite of exemestane . It is formed by metabolism of exemestane by the cytochrome P450 (CYP) isoforms CYP1A and CYP4A11. 17β-hydroxy Exemestane is an aromatase inhibitor (... |
