ROR

The RAR-related orphan receptors (RORs) are members of the nuclear receptor family of intracellular transcription factors. There are three forms of ROR, ROR-α, -β, and -γ and each is encoded by a separate gene RORA, RORB, and RORC respectively. The RORs are somewhat unusual in that they appear to bind as monomers to hormone response elements as opposed to the majority of other nuclear receptors which bind as dimers. They bind to DNA elements called ROR response elements (RORE).

Cat. No.	製品名	CAS No.	Purity
T9623	RORγt inverse agonist 13	2170477-75-3	98%
T9623	RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist (IC50=63.8 nM), with improved drug-like properties[1].
T13172L1	TMP-778	1422171-08-1	98%
T13172L1	TMP-778 is a selective inverse agonist of RORγt.
T12753	RORγt Inverse agonist 6	1887161-80-9	98%
T12753	RORγt Inverse agonist 6 is an agonist of RORγt inverse. RORγt Inverse agonist 6 can be used in research on Th17-driven autoimmune diseases.
T4670	SR0987	303126-97-8
T4670	SR0987 is a RORγt agonist,
T4594	SR1078	1246525-60-9
T4594	SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ.
T5164	Cabozantinib hydrochloride	1817759-42-4	97.09%
T5164	Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM...
T7388	GSK805	1426802-50-7	98%
T7388	GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand bindi...
T13502	3-Oxo-5β-cholanoic acid	1553-56-6	98.01%
T13502	3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (Dehydrolithocholic acid) is a bile acid metabolite and inhibits the differentiation of TH17 cells by directly ...
T16929	SR2211	1359164-11-6	98.2%
T16929	SR2211 is a specific modulator and an inverse agonist of RORγ(IC50 = 320 nM, Ki = 105 nM).
T39250	Bevurogant	1817773-66-2	98.78%
T39250	Bevurogant is an antagonist of RORγt receptor and can be used in studies about the treatment of chronic inflammatory diseases.
T13362	XY101	2349368-16-5	98.81%
T13362	XY101 is a selective, metabolically stable and orally available agonist of RORγ inverse(IC50 of 30 nM and a Kd of 380 nM).
TQ0007	Cintirorgon	2055536-64-4	98.85%
TQ0007	Cintirorgon (LYC-55716) is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.
T2834	Nobiletin	478-01-3	98.88%
T2834	Nobiletin (Hexamethoxyflavone) is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities. Nobiletin is pr...
T5163	SR1001	1335106-03-0	99.04%
T5163	SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM).
T5160	SR3335	293753-05-6	99.41%
T5160	SR3335 (ML 176) is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).
T6690	T0901317	293754-55-9	99.43%
T6690	T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
T3S1251	Neoruscogenin	17676-33-4	99.5%
T3S1251	1. Neoruscogenin represents a universal pharmacological tool for RORα research due to its specific selectivity profile versus other nuclear receptors.
T9635	Cedirogant	2055496-11-0	99.57%
T9635	Cedirogant (ABBV-157) is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study.
T37587	ML 209	1334526-14-5	99.65%
T37587	ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 μM in a reporter assay).1It inhibits RORγt-induced transcription i...
T14369	AZD-0284	2101291-07-8	99.75%
T14369	AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].