|
T1463 |
Ramelteon
|
TAK-375 |
Melatonin Receptor
,
MT Receptor
|
|
Ramelteon (TAK-375) is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist. |
|
T12877L |
Seltorexant
|
JNJ-42847922 |
OX Receptor
|
|
Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 receptor antagonist (pKi: 8.0 and 8.1 for human a... |
|
T3722 |
MK-1064
|
Urokinase inhibitor 1,MK 1064 |
OX Receptor
|
|
MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA). |
|
T14983 |
Clomethiazole
|
Distraneurin,Chlormethiazole,5-(2-CHLOROETHYL)-4-METHYLTHIAZOLE |
P450
,
GABA Receptor
|
|
Clomethiazole (Distraneurin) is an orally active GABAA agonist and it is an anticonvulsant agent. It also has the potential for treating convulsive status epilepticus. Chlormethiazole inhibits cytochrome P450 isoforms: C... |
|
T41143 |
PCPA methyl ester hydrochloride
|
4-Chloro-DL-phenylalanine methyl ester hydrochloride |
5-HT Receptor
,
Hydroxylase
|
|
pCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) is an inhibitor of tryptophan hydroxylase inhibitor and 5-HT synthesis. pCPA methyl ester hydrochloride is permeable across the blood... |
|
T67782 |
Daridorexant hydrochloride
|
Nemorexant hydrochloride,Quviviq |
OX Receptor
|
|
Daridorexant hydrochloride (Nemorexant hydrochloride) is a New Dual Orexin Receptor Antagonist. Daridorexant hydrochloride can be used for Insomnia research. |
|
T32105 |
Cipepofol
|
HSK3486,HSK 3486,HSK-3486 |
|
|
HSK3486 is similar to propofol and is a general anesthetic, which may have therapeutic potential in insomnia, migraine, anxiety, analgesia, and other aspects. |
|
T5500 |
DORA-22
|
|
OX Receptor
|
|
DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory |
|
T30188L |
Atagabalin HCl
|
PD-0200390 HCl,Atagabalin HCl(223445-75-8 Free base） |
Calcium Channel
|
|
Atagabalin HCl is a novel voltage-dependent calcium channel (VDCC) α2δ subunit (1 and 2) ligand that affects slow-wave sleep and can be used to treat insomnia. |
|
T37979 |
N-Desmethyl Pimavanserin
|
AC-279 |
5-HT Receptor
|
|
N-Desmethyl Pimavanserin (AC-279) is the active metabolite of Pimavanserin, a 5-HT2A receptor inverse agonist, which is used in the treatment of sleep disorders such as insomnia. |
|
T1619 |
Trazodone hydrochloride
|
KB-831,Trazodone HCl,AF-1161 |
5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Trazodone hydrochloride (Trazodone HCl) is a serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressi... |
|
T22530 |
6-Chloromelatonin
|
|
Melatonin Receptor
,
Dopamine Receptor
|
|
6-Chloromelatonin is a potent melatonin receptor agonist, a 5-methoxyindole compound that competes for the same presynaptic melatonin receptor sites in the rabbit retina and inhibits the calcium-dependent release of [3H]... |
|
T69715 |
ORN-0829 hydrate
|
|
|
|
ORN-0829 hydrate is a potent dual orexin 1/2 receptor antagonist for the treatment of insomnia. |
|
T61088 |
Propiomazine
|
|
|
|
Propiomazine is an orally active antihistamine agent that possesses sedative properties. It finds utility in insomnia research [1] [2]. |
|
T26061 |
Reposal
|
WT-161,Reposamal,Reposal novo,WT161,WT 161 |
|
|
Reposal is a barbiturate derivative invented in the 1960s in Denmark. It has hypnotic, sedative, and anticonvulsant properties, and was used primarily for the therapy of insomnia. |
|
T29008 |
Triclofos Sodium
|
SCH-10159,SCH 10159,SCH10159 |
|
|
Triclofos Sodium is used to treat insomnia and used for sedation. |
|
T69063 |
Orvepitant
|
|
|
|
Orvepitant is a potent and selective NK1 antagonist, which may be potentially useful for patients with major depressive disorder (MDD), anxiety and insomnia. |
|
T68469 |
NBI-75043
|
|
|
|
NBI-75043 is a histamine H1 receptor antagonist, for potential use in the treatment of insomnia. |
|
T30188 |
Atagabalin
|
PD 0200390,PD-0200390,PD0200390 |
|
|
Atagabalin, also known as PD 0200390, is a gabamimetic agent under development for the treatment for insomnia. Atagabalin is related to gabapentin, which similarly binds to the α2δ calcium channels (1 and 2). It was disc... |
|
T38139 |
Orexin receptor antagonist 2
|
|
|
|
Orexin Receptor Antagonist 2 (compound 30), characterized by its potent antagonistic activity with pKis of 7.69 and 9.78, holds promise for insomnia research[1]. |
|
T39004 |
Vornorexant
|
ORN-0829,TS-142 |
|
|
Vornorexant (ORN-0829; TS-142) is a potent dual OX1R and OX2R antagonist with IC 50 values of 1.05 nM and 1.27 nM, respectively. Vornorexant exhibits potent sleep-promoting effects in vivo and can be used for insomnia tr... |
|
T72954 |
Fazamorexant
|
YZJ-1139 |
|
|
Fazamorexant (YZJ-1139) is a powerful orexin receptor antagonist effective for insomnia research. |
|
T32833 |
Lobeline, (+)-
|
(+)-Lobeline |
|
|
Lobeline, (+)- is an alkaloid that has actions similar to nicotine on nicotinic cholinergic receptors but is less potent. It has been proposed for a variety of therapeutic uses including in respiratory disorders, periphe... |
|
T69419 |
Vestipitant mesylate
|
|
|
|
Vestipitant mesylate is one of the most potent and selective NK(1) receptor antagonists ever discovered, showing appropriate pharmacokinetic properties and in vivo activity. Its actions support the utility of NK(1) recep... |
|
T69420 |
Vestipitant
|
|
|
|
Vestipitant, also known as GW597599, is one of the most potent and selective NK(1) receptor antagonists ever discovered, showing appropriate pharmacokinetic properties and in vivo activity. Its actions support the utilit... |
|
TMIH-0582 |
Trazodone-d8 hydrochloride
|
|
|
|
Trazodone-d8 hydrochloride is a deuterated compound of Trazodone hydrochloride. Trazodone hydrochloride has a CAS number of 25332-39-2. Trazodone hydrochloride is a serotonin uptake inhibitor that is used as an antidepre... |
