store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ramelteon (TAK-375) is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist.
説明 | Ramelteon (TAK-375) is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist. |
ターゲット&IC50 | MT2 receptor:112 pM(Ki), MT receptor (chicken):23.1 pM(Ki), MT1 receptor:14 pM(Ki) |
キナーゼ試験 | cDNA encoding the human MT1 gene is introduced into CHO cells. Cells are harvested at confluence in Ca2+ and Mg2+ free Hanks' balanced salt solution containing 5 mM EDTA and collected by centrifugation. Cells are homogenized in ice-cold 50 mM Tris–HCl buffer, washed twice, pelleted, and stored at -30°C until the binding assays are conducted. Test compound and 40 pM 2-[ 125I]melatonin are mixed with the thawed homogenate in a total volume of 1 mL and incubated at 25°C for 150 min. The reaction is terminated by addition of 3 mL of icecold buffer followed by vacuum filtration on a Whatman GF/B. The filter is washed twice and radioactivity is counted by a g-counter[1]. |
別名 | TAK-375 |
分子量 | 259.34 |
分子式 | C16H21NO2 |
CAS No. | 196597-26-9 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 49 mg/mL (188.9 mM)
DMSO: 49 mg/mL (188.9 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Ramelteon 196597-26-9 GPCR/G Protein Neuroscience Melatonin Receptor MT Receptor TAK375 rebound insomnia TAK-375 insomnia MT2 withdrawal symptom MT1 inhibit discontinuation Inhibitor next-morning residual effect oral TAK 375 inhibitor