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T23101 |
O-3M3FBS
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Others
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Inactive analog of m-3M3FBS (PLC activator) |
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T22408 |
Proflavine
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3,6-Diaminoacridine |
Antibacterial
|
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Proflavine (3,6-Diaminoacridine) (3,6-Diaminoacridine) is a disinfectant bacteriostatic against many gram-positive bacteria and is a topical antiseptic used mainly in wound dressings. |
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T0438 |
Proflavine Hemisulfate
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3,6-Diaminoacridine hemisulfate,Proflavin hemisulfate |
Others
,
Potassium Channel
,
DNA
,
Thrombin
,
Antibacterial
,
Autophagy
|
|
Proflavine Hemisulfate (3,6-Diaminoacridine hemisulfate) is the hemisulfate salt form of proflavine, an acridine-derived fluorescent contrast and disinfectant agent that can potentially be used for cellular imaging and a... |
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T4542 |
Clonixin
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Clonixic acid |
Others
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Clonixin (Clonixic acid) is a non-steroidal anti-inflammatory drug (NSAID) with analgesic properties. This compound has been reported to block prostaglandin synthesis, and to block inward calcium currents. |
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T21263 |
Amlodipine maleate
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Amlodipine (+-)-form maleate,Amvaz |
Calcium Channel
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Amlodipine maleate (Amvaz) is an orally active dihydropyridine calcium channel blocker that inhibits calcium inward flow by blocking voltage-dependent L-type calcium channels.Amlodipine maleate is used in the study of hy... |
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T27205 |
DPI 201-106
|
DPI-201-106 |
Sodium Channel
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DPI-201-106 is a cardioselective inhibitor of the TTX-resistant h1 Na channel inactivation. DPI-201-106 inhibits the L-type calcium current, and inward and delayed rectifier potassium currents. |
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T6541 |
Ibutilide Fumarate
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Corvert Fumarate,U70226E |
Calcium Channel
,
Sodium Channel
|
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Ibutilide Fumarate (U70226E) is the fumarate salt form of ibutilide, a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow, inward, predominately sodium current rather than by blocking outwar... |
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T0866 |
Propafenone
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Rythmol,Propafenonum |
Potassium Channel
,
MRP
,
Sodium Channel
|
|
Propafenone (Propafenonum) is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.... |
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T15555 |
IK1 inhibitor PA-6
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Potassium Channel
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IK1 inhibitor PA-6 (PA-6) is a selective and potent inhibitor of IK1 (KIR2.x ion-channel-carried inward rectifier current)(IC50 of 12-15 nM for human and mouse KIR2.x currents). |
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T36033 |
DETA NONOate
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NOC-18,Diethylamine NONOate |
NO Synthase
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DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor with vasodilatory and antidepressant activity.DETA NONOate can be used to activate inward currents in neurons, which may accelerate the healing of MRSA-infect... |
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T22361 |
Mepivacaine
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Carbocaine |
Sodium Channel
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Mepivacaine (Carbocaine) is an amide compound for local anaesthesia that causes transient loss of self-consciousness in humans or animals. mepivacaine acts by binding to specific voltage-gated sodium channels in nerve ce... |
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T0207 |
Ranolazine dihydrochloride
|
RS 43285,Ranolazine 2HCl |
Calcium Channel
,
Sodium Channel
,
Autophagy
|
|
Ranolazine dihydrochloride (Ranolazine 2HCl) , an antianginal agent, can treat arrhythmia via a novel mechanism of action (inhibition of the late phase of the inward sodium current), and do not affect blood pressure or h... |
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T13387L |
Zatebradine hydrochloride
|
UL-FS-49CL,UL-FS-49 |
Others
,
HCN Channel
|
|
Zatebradine hydrochloride (UL-FS-49CL) is a highly effective and effective HCN Channel inhibitor (IC50:1.96 µM). HCN Channel is an effective hyperpolarization activated loop nucleotide gated channel. Zatebradine hydrochl... |
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T2535 |
Ivabradine hydrochloride
|
S 16257-2,Ivabradine HCl |
Adrenergic Receptor
|
|
Ivabradine hydrochloride (S 16257-2) is a new If inhibitor (IC50: 2.9 μM). Ivabradine Hydrochloride is the hydrochloride salt form of ivabradine, an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gat... |
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T19839 |
Oxatomide
|
Oxatomida |
P2X Receptor
,
Calcium Channel
,
5-HT Receptor
,
Histamine Receptor
|
|
Oxatomide (Oxatomida) is a potent and orally active dual H1 histamine receptor and P2X7 receptor antagonist with antihistamine and antiallergic activity.Oxatomide can be used to block ATP-induced currents in the human P2... |
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T24948 |
VU625
|
VU007625,VU 625,VU 007625,VU-625,VU-007625 |
|
|
VU625 is an effective inhibitor of Aedes aegypti inward rectifier potassium channels. |
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T5336L |
Zacopride
|
Racemic zacopride |
|
|
Zacopride is a selective agonist of inward rectifier potassium current (I K1) channel, inhibiting ventricular arrhythmias without affecting atrial arrhythmias. |
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T23012 |
MNI caged kainic acid
|
|
Others
|
|
Generates large inward currents at resting membrane potential |
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T80510 |
Tertiapin-RQ
|
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Potassium Channel
|
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Tertiapin-RQ, an inward rectifier potassium (K+) channel-blocking peptide, exhibits antidepressant effects [1]. |
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T71406 |
SA 2572
|
|
|
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SA 2572 is a newly synthesized Ca2+ antagonist having a inhibitory effect on the fast Na+ inward channel. |
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T70063 |
GYKI 52466 HCl
|
|
|
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GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 µM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 µM but also i... |
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T68361 |
Asocainol hydrochloride
|
|
|
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Asocainol hydrochloride ia an antiarrhythmic drug which inhibits slow Ca2+ influx. This is accompanied by alterations in normal Na+-carried action potentials. Therefore, Asocainol not only inhibits Ca2+ inflow but also i... |
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T17240 |
VU041
|
|
Others
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VU041 is an inhibitor of Anopheles gambiae and Aedes aegypti inward rectifier potassium 1 channels (IC50: 2.5 μM and 1.7 μM, respectively). VU041 inhibits appreciably is mammalian Kir2.1 (IC50: 12.7 μM) and has less inhi... |
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T37093 |
4,9-Anhydrotetrodotoxin
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4,9-Anhydrotetrodotoxin,4,9-anhydro-TTX |
|
|
4,9-Anhydrotetrodotoxin (4,9-anhydro-TTX) is a derivative of TTX that selectively blocks inward sodium current through Nav1.6 voltage-activated sodium channels (IC50 = 7.8 nM in Xenopus oocytes). [1][2][3] It demonstrate... |
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TP1967 |
Phrixotoxin 3
|
|
|
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Potent blocker of voltage-gated sodium channels (IC50 values are 0.6, 42, and 72 nM for NaV1.2, NaV1.3 and NaV1.5 respectively). Blocks inward sodium currents in a voltage-dependent manner. |
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T36740 |
Guanosine 5’-diphosphate (sodium salt hydrate)
|
|
|
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Guanosine 5’-diphosphate (GDP) is a purine nucleotide and biosynthetic precursor of guanosine 5’-triphosphate .1It has been used to study the conformations of GTPases.2GDP (100 μM) activates sulfonylurea receptor 2B (SUR... |
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TP2114 |
Tertiapin-Q
|
|
|
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A high affinity blocker for inward-rectifier K+ channels, this compound is a stable derivative of the bee venom toxin tertiapin. Binds to ROMK1 (Kir1.1) and GIRK1/4 (Kir3.1/3.4) channels with high affinity (Ki values are... |
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T41209 |
DPNB-ABT 594
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|
|
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DPNB-ABT 594 is a nitrobenzyl-caged ABT 594, a selective α4β2 nAChR agonist. One-photon uncaging evokes large inward currents and Ca2+transients on cell bodies and dendrites of medial habenular neurons in mouse brain sli... |
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T63445 |
Amlodipine mesylate
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|
|
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Amlodipine mesylate is an oral active dihydropyridine calcium channel blocker that blocks voltage-dependent L-type calcium channels and inhibits calcium inward flow, and is an anti-anginal agent. amlodipine mesylate can ... |
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T37199 |
Bilaid C
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|
|
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Bilaid C is a tetrapeptide μ-opioid receptor agonist (Ki= 210 nM in HEK293 cell membranes expressing the human receptor) that has been found inPenicillium.1It inhibits forskolin-induced cAMP accumulation by 77% in HEK293... |
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T70987 |
AT-1001
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|
|
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AT-1001 is an α3β4 nAChR partial agonist. AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats. AT-1001 also potently and reversib... |
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T75855 |
Phrixotoxin 3 TFA
|
|
|
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Phrixotoxin 3 TFA is a potent inhibitor of voltage-gated sodium channels, demonstrating IC50 values of 0.6 nM for NaV1.2, 42 nM for NaV1.3, 72 nM for NaV1.4, 288 nM for NaV1.1, and 610 nM for NaV1.5, respectively. This c... |
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TP1513 |
Egg Laying Hormone, aplysia
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|
|
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Egg-laying hormone (ELH) is a neuropeptide synthesized by the bag cell neurons, Egg-laying hormone (ELH) induces egg laying and its correlated behavior in Aplysia californica. Egg-laying hormone (ELH) has been purified t... |
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TP2016 |
Huwentoxin-IV
|
Huwentoxin IV |
|
|
Selective NaV1.7 channel blocker. Preferentially inhibits neuronal NaV1.7, 1.2 and 1.3 (IC50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes NaV1.4 and 1.5 (IC50 = >10 μM). Inhibits the channel b... |
|
TMIH-0087 |
Amlodipine-d4 Maleate (Racemic)
|
|
|
|
Amlodipine-d4 Maleate (Racemic) is a deuterated compound of Amlodipine Maleate (Racemic). Amlodipine Maleate (Racemic) has a CAS number of 88150-47-4. Amlodipine maleate is an orally active dihydropyridine calcium channe... |
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T83749 |
Tertiapin LQ TFA
|
TPNLQ |
|
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Tertiapin LQ, a peptide derivative of honeybee venom peptide tertiapin, acts as an inhibitor of inwardly rectifying potassium (Kir) channels. Specifically, it targets and inhibits heteromultimeric potassium channels, inc... |
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T69600 |
Spermidine-d6
|
|
|
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Spermidine-d6 is intended for use as an internal standard for the quantification of spermidine by GC- or LC-MS. Spermidine is an endogenous polyamine. It is formed from putrescine by spermidine synthase. Spermidine (25 µ... |
