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T32558 |
Lanosteryl acetate
|
Lanosterol acetate |
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Lanosteryl acetate is a bioactive chemical. |
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T8490 |
Butoconazole
|
1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole |
Antifungal
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Butoconazole (1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole) is an imidazole antifungal agent |
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T3934 |
Isavuconazonium sulfate
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Antifungal
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Isavuconazonium sulfate is hydrolyzed by plasma esterases to yield the active moiety isavuconazole. Isavuconazole binds to and inhibits the fungal cytochrome P450 family enzyme lanosterol 14-alpha-demethylase (CYP51), wh... |
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T7866 |
Difenoconazole
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Others
,
Antifungal
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Difenoconazole is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell ... |
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T5966 |
Hexaconazole
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(-)-Hexaconazol |
Reactive Oxygen Species
,
Antifungal
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Hexaconazole ((-)-Hexaconazol) is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of ... |
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T1438 |
Butoconazole nitrate
|
RS 35887 |
Estrogen/progestogen Receptor
,
Antifungal
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Butoconazole Nitrate is the nitrate salt form of butoconazole, a synthetic imidazole derivative with fungistatic properties. Butoconazole nitrate (RS 35887) interferes with steroid biosynthesis by inhibiting the conversi... |
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T1187 |
Bifonazole
|
Bay H-4502 |
P450
,
Antibiotic
,
Antifungal
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Bifonazole (Bay H-4502) acts to destabilize the fungal cytochrome p450 51 enzyme (also known as Lanosterol 14-alpha-demethylase). It works by inhibiting the production of a substance called ergosterol, which is an essent... |
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T1290 |
Oxiconazole nitrate
|
Ro 13-8996 |
Others
,
Antibiotic
,
Antifection
,
Antifungal
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Oxiconazole nitrate (Ro 13-8996) is the nitrate salt form of oxiconazole, a broad spectrum imidazole derivative with antifungal activity. Although the exact mechanism of action has yet to be fully elucidated, oxiconazole... |
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T4039 |
BIBB 515
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Others
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BIBB 515 is a selective and potent inhibitor of OSC in vivo with an ED50 value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively. 2, 3-Oxidosqualene cyclase (OSC) is an important enzyme in the biosynthesis of... |
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T25625 |
Lanomycin
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|
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Lanomycin, isolated from Pycnidiophora dispersa, inhibits lanosterol 14alpha-demethylase. |
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T25127 |
Azalanstat
|
RS-21607,RS 21607,RS21607 |
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Azalanstat is a lanosterol 14 alpha-demethylase inhibitor. The enzyme catalyzes the first step in the conversion of lanosterol to cholesterol in mammals. |
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T71536 |
Mdl 28815
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Mdl 28815 is a potent inhibitor of 2,3-oxidosqualene cycloartenol & lanosterol cyclases. |
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T26191 |
SK&F 104976
|
SK&F104976,Skf104976,Skf 104976,SK&F-104976,Skf-104976 |
|
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SK&F 104976 is a 32-carboxylic acid derivative of lanosterol. It was found to be a potent lanosterol 14 alpha-demethylase (14 alpha DM) inhibitor. |
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T32095 |
Holothurinogenin
|
Nobilisidenol A |
|
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Holothurinogenin, as a lanosterol derivative, has toxic to nerve tissue. |
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T69167 |
Buthiobate
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|
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Buthiobate is a fungicide which inhibits lanosterol 14 alpha-demethylation catalyzed by a cytochrome P-450. |
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T26424 |
A 60586
|
A60586,A-60586 |
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A 60586, a non-azole inhibitor of ergosterol biosynthesis, inhibits lanosterol 14alpha-demethylase and displays in-vitro antifungal activity. |
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T70158 |
Quilseconazole besylate
|
|
|
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Quilseconazole besylate, also known as VT-1129 besylate, is a potent, orally active fungal Cyp51 (lanosterol 14-α-demethylase) inhibitor. |
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T64029 |
Antifungal agent 42
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|
|
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Antifungal agent 42 is an antifungal agent that has an inhibitory effect on biofilm formation. Antifungal agent 42 inhibits C.alb.'s lanosterol 14α-demethylase (CYP51). |
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T63285 |
Antifungal agent 40
|
|
|
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Antifungal agent 40 is an antifungal agent that extends into the narrow hydrophobic pocket II of C. alb. CYP51 and inhibits the activity of lanosterol 14α-demethylase (CYP51), which has an inhibitory effect on biofilm fo... |
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T70660 |
Azalanstat HCl
|
|
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Azalanstat HCl is an anti-obesity drug acting as a lanosterol 14α-demethylase inhibitor. Azalanstat HCl has been shown to inhibit cholesterol synthesis in HepG2 cells, human fibroblasts, hamster hepatocytes and hamster l... |
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T70661 |
Azalanstat mesylate
|
|
|
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Azalanstat mesylate is an anti-obesity drug acting as a lanosterol 14α-demethylase inhibitor. Azalanstat mesylate has been shown to inhibit cholesterol synthesis in HepG2 cells, human fibroblasts, hamster hepatocytes and... |
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T68998 |
Parconazole Free Base
|
|
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Parconazole Free Base is used in veterinary as an oral fungicide with a broad-spectrum activity against dermatophytes, yeasts, and others fungi. This compound does not have any antibacterial effect. The mechanism of acti... |
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T64105 |
Voriconazole camphorsulfonate
|
|
|
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Voriconazole (UK-109496) camphorsulfonate is a second generation broad-spectrum triazole antifungal compound that exhibits inhibition of fungal ergosterol biosynthesis. Voriconazole camphorsulfonate exhibits antifungal e... |
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T79550 |
Antifungal agent 68
|
|
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Antifungal agent 68 (compound 10) effectively combats fungal infections caused by Candida and Cryptococcus gattii through the inhibition of ergosterol biosynthesis, likely via interaction with lanosterol 14α-demethylase ... |
