ペプチド
抗体
色素試薬
PROTAC
バーチャルスクリーニング
TargetMolキット
Cell Counting Kit-8 (CCK-8)
Inhibitor Cocktails
天然化合物
フェノール類
アルカロイド類
フラボノイド類
阻害剤
血管新生
アポトーシス
オートファジー
細胞周期・チェックポイント
クロマチン・エピジェネティック
細胞骨格シグナル
DNA損傷・DNA修復
内分泌・ホルモン
GPCR/Gタンパク質
免疫・炎症
JAK・STATシグナル
| Cat. No. | 製品名 | CAS No. | Purity | Chemical Structure |
|---|---|---|---|---|
| T1926 | Sonidegib | 956697-53-3 | 98% |
|
| LDE225 (NVP-LDE225; Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively. | ||||
| T40465 | SAG dihydrochloride | 2702366-44-5 | 98% |
|
| SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist ( EC 50 =3 nM; K d =59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and co... | ||||
| T22814 | GSA-10 | 300833-95-8 | 98% |
|
| Smoothened (Smo) receptor agonist | ||||
| T4211 | SAG hydrochloride (912545-86-9(free base)) | 2095432-58-7 | 98% |
|
| SAG hydrochloride is a chlorobenzothiophene-containing compound which acts as a SMO agonist. | ||||
| T1543 | Naftifine hydrochloride | 65473-14-5 | 98% |
|
| Naftifine Hydrochloride is the hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exact... | ||||
| T2450 | SANT-1 | 304909-07-7 | 98% |
|
| SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM). | ||||
| T1094 | Tolnaftate | 2398-96-1 | 98% |
|
| Tolnaftate is a synthetic antifungal agent. | ||||
| T1011 | Itraconazole | 84625-61-6 | 98% |
|
| Itraconazole is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis. | ||||
| T14965 | Ciliobrevin D | 1370554-01-0 | 98% |
|
| Ciliobrevin D is a AAA+ ATPase motor cytoplasmic dynein inhibitor. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation and it also inhibit... | ||||
| T23370 | SMANT hydrochloride | 1177600-74-6 | 98% |
|
| SMANT hydrochloride is an antagonist of Smoothened accumulation. | ||||
| T22089 | HPI 1 | 599150-20-6 | 98% |
|
| HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5... | ||||
| T15019L | CUR61414 hydrochloride | 98% |
|
|
| CUR61414 is a potent and cell permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM). CUR61414 is a small-molecule aminoproline class compound. CUR... | ||||
| T3460 | HhAntag | 496794-70-8 | 98% |
|
| HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity.... | ||||
| T15019 | CUR61414 | 334998-36-6 | 98% |
|
| CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM). | ||||
| T6514 | Glasdegib | 1095173-27-5 | 98% |
|
| Glasdegib (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2. | ||||
| T1810 | Purmorphamine | 483367-10-8 | 98% |
|
| Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of osteoblast differentiation. | ||||
| T1779 | SAG | 912545-86-9 | 98% |
|
| SAG is a potent Smo receptor agonist and activates the Hedgehog signaling pathway. | ||||
| T3070 | GANT 61 | 500579-04-4 | 98% |
|
| GANT 61 is an inhibitor for Gli1 and Gli2. | ||||
| T2825 | Cyclopamine | 4449-51-8 | 98% |
|
| Cyclopamine, a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids. | ||||
| T14188 | ALLO-2 | 1357350-60-7 | 98% |
|
| ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM. | ||||
