Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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50 mg | 在庫あり | ¥ 8,000 | |||
100 mg | 在庫あり | ¥ 11,000 | |||
200 mg | 在庫あり | ¥ 18,000 | |||
500 mg | 在庫あり | ¥ 41,000 |
説明 | Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis. |
ターゲット&IC50 | CYP3A4:6.1 nM |
In vitro | Like other Hedgehog (Hh) pathway antagonists, Itraconazole can inhibit the activity of the Hh pathway and the growth of medulloblastoma in a murine syngeneic transplant model. |
In vivo | Itraconazole exhibits affinity for mammalian cytochrome P-450 enzymes and fungal P-450-dependent enzymes, thereby possessing potential for clinically significant interactions with azoles (e.g., simvastatin, terfenadine, rifampin, oral contraceptives, H2 receptor antagonists, warfarin, cyclosporine). Metabolized into hydroxy-itraconazole (OH-ITZ) and two novel metabolites, keto-itraconazole (keto-ITZ) and N-desalkyl itraconazole (ND-ITZ), its metabolites are inhibitors of CYP3A4 as potent, or more so, than itraconazole itself. Itraconazole acts on the hedgehog (Hh) signaling pathway component Smoothened with a mechanism distinct from cyclopamine and other known SMO antagonists, preventing SMO accumulation stimulated by Hh activation. It inhibits 60 clinical isolates of Aspergillus with MICs at 0.25 mg/mL, primarily by damaging ergosterol synthesis, leading to defective fungal cell membranes with altered permeability and function. |
別名 | R51211 |
分子量 | 705.63 |
分子式 | C35H38Cl2N8O4 |
CAS No. | 84625-61-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 7.06 mg/mL (10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Itraconazole 84625-61-6 Autophagy GPCR/G Protein Metabolism Microbiology/Virology Stem Cells Hedgehog/Smoothened P450 Antifungal Antibiotic Inhibitor inhibit Fungal R-51211 CYP-450 lanosterol anticancer Triazole Hedgehog ergosterol Cytochrome P450 antiangiogenic R51211 antifungal CYPs 14α-demethylase R 51211 inhibitor