|
T15260 |
Evenamide
|
NW-3509 |
Sodium Channel
|
|
Evenamide (NW-3509) is a sodium channel blocker. Which shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness. |
|
T61710 |
Antileishmanial agent-7
|
|
|
|
Antileishmanial agent-7 (compound 23) exhibits strong antileishmanial activity against Leishmania donovani and L-6, with IC50 values of 6.89 and 259 μM, respectively [1]. |
|
T61199 |
Antileishmanial agent-2
|
|
|
|
Antileishmanial agent-2 demonstrates potent submicromolar antileishmanial activity (IC50 = 0.29 μM) and a remarkable selectivity index against mammalian cells. |
|
T61560 |
Antileishmanial agent-5
|
|
|
|
Antileishmanial agent-4 is a ribonucleoside analogue with potent activity against L.infantum and T.cruzi, having EC 50 values of 0.68 μM and 0.83 μM, respectively [1]. |
|
T63281 |
Antileishmanial agent-11
|
|
|
|
Antileishmanial agent-11 is a potent antileishmanial agent that acts on Leishmania brazilensis (IC50: 28.3 μM), Leishmania infantum (IC50: 24.8 μM) and T. cruzi (IC50: 13.0 μM) with outstanding antiprotozoal effect. |
|
T61391 |
Antileishmanial agent-3
|
|
|
|
Antileishmanial agent-3 (Compound 13) effectively inhibits the growth of Leishmania major [1]. |
|
T62574 |
Antileishmanial agent-6
|
|
|
|
Antileishmanial agent-6 is a potent anti-leishmanial agent with anti-leishmanial activity (IC50: 0.54 μM) and cytotoxicity (IC50: 10.2 μM) against Leishmania donovani and L-6. |
|
T78963 |
Antileishmanial agent-16
|
|
Parasite
|
|
Antileishmanial agent-16 (compound 14c), an anti-Leishmania agent, exhibits potent activity against Leishmania major promastigotes (IC50 = 0.59 µM) and amastigotes (IC50 = 0.81 µM), while maintaining a favorable safety p... |
|
T61416 |
Antileishmanial agent-9
|
|
|
|
Antileishmanial agent-9 (compound 16c) exhibits potent and selective activity against Leishmania donovani (L. donovani) with an IC50 value of 4.01 μM. In addition, this compound demonstrates relatively low cytotoxicity i... |
|
T62330 |
Antileishmanial agent-12
|
|
|
|
Antileishmanial agent-12 (compound 5a) is a potent anti-leishmanial agent with antibacterial activity against Leishmania brazilensis (IC50: 14.9 μM), Leishmania infantum (IC50: 21.3 μM) and T. cruzi (IC50. 9.3 μM). 9.3 μ... |
|
T61100 |
Antileishmanial agent-4
|
|
|
|
Antileishmanial agent-4, a ribonucleoside analogue, functions as an antileishmanial agent [1]. |
|
TP2331 |
Leishmania peptide 183
|
Peptide 183,p183,Leishmania |
|
|
Leishmania peptide 183 is an antigen. |
|
T40117 |
Antileishmanial agent-1
|
|
|
|
Antileishmanial agent-1 demonstrates activity against both L. amazonensis promastigotes (IC 50 = 15.52 μM) and intracellular amastigotes (IC 50 = 4.10 μM). |
|
T72260 |
Antileishmanial agent-13
|
|
|
|
Antileishmanial agent-13, a quinoline-isatin hybrid, functions as an antileishmanial agent targeting the L. Major Leishmania strain through an anti-folate mechanism. This compound exhibits potent inhibition of both the p... |
|
T62210 |
Antileishmanial agent-10
|
|
|
|
Antileishmanial agent-10 (Compound 7h) is an antiprotozoal agent. |
|
T83045 |
Antileishmanial agent-25
|
|
Parasite
|
|
Antileishmanial agent-25 (compound 24) exhibits selective activity against intracellular amastigotes, demonstrating an inhibitory concentration (IC50) of 6.63 μM [1]. |
|
T79632 |
Antileishmanial agent-21
|
|
Parasite
|
|
Antileishmanial agent-21 (compound 4e) functions as an inhibitor of Leishmania pteridine reductase 1 (Lm-PTR1), employing an anti-folate mechanism. Its antileishmanial effects can be negated by folic acid and leucovorin.... |
|
T78680 |
Antileishmanial agent-14
|
|
Parasite
|
|
Antileishmanial agent-14, a sulfuretin analog, exhibits potential activity against Leishmania donovani promastigotes (IC 50 = 4.1 μM) and inhibits infection by L. donovani amastigotes (IC 50 = 11.1 μM) [1]. |
|
T78962 |
Antileishmanial agent-15
|
|
Parasite
|
|
Antileishmanial agent-15 (compound 13c) exhibits potent activity against L. major promastigotes and amastigotes, demonstrating IC50 values of 0.78 μM for promastigotes and 0.99 μM for amastigotes, while also showing cyto... |
|
T79390 |
Antileishmanial agent-23
|
|
Parasite
|
|
Antileishmanial agent-23 (compound G1/9), a potent and selective trypanothione reductase (TR) inhibitor, exhibits an IC50 of 2.24 ± 0.52 μM. It effectively inhibits the growth of Leishmania, Trypanosoma cruzi, and Trypan... |
|
T79419 |
Antileishmanial agent-24
|
|
Parasite
|
|
Antileishmanial agent-24 (compound 33) exhibits antileishmanial activity, demonstrating an inhibitory concentration 50 (IC50) value of 5.39 μM against amastigotes [1]. |
|
T60638 |
Antileishmanial agent-8
|
|
|
|
Antileishmanial agent-8 (compound 18) shows potent and selective activity against Leishmania donovani ( L. donovani ) (IC50 = 5.64 μM) with relatively low cytotoxicity in L-6 cells (IC 50 =73.9 μM) [1]. |
|
T79633 |
Antileishmanial agent-22
|
|
Parasite
|
|
Antileishmanial agent-22 (compound 15b) serves as an antiparasitic and antibacterial, exhibiting activities against Leishmania (IC50 = 0.408 μM), malaria, and tuberculosis. It operates on an antifolate mechanism, suppres... |
|
T79471 |
Antileishmanial agent-20
|
|
Parasite
|
|
Antileishmanial agent-20 exhibits selectivity against the Leishmania parasite, with IC50 values of 2.8 μM for L. infantum and 0.2 μM for L. braziliensis. It is a potential research tool for studying these parasites [1]. |
|
T79449 |
Antileishmanial agent-19
|
|
Parasite
|
|
Compound F27 (Antileishmanial agent-19) is an antileishmanial compound effective against L. donovani promastigotes, demonstrating an IC50 of 3.39 μM. It functions by inhibiting the Leishmania prolyl-tRNA synthetase and d... |
|
T78964 |
Antileishmanial agent-17
|
|
Parasite
|
|
Antileishmanial agent-17, a coumarin hybrid, exhibits potent antileishmanial activity (IC50 <0.78 μM) while proving non-toxic to normal VERO cells. It specifically interacts with the folate pathway enzymes pteridine redu... |
|
T6241 |
Quetiapine hemifumarate
|
Quetiapine Fumarate,ICI-204636 |
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
|
|
Quetiapine hemifumarate (ICI-204636), an atypical antipsychotic, is used in the treatment of bipolar I mania, schizophrenia, bipolar II depression, bipolar I depression. |
|
T15117 |
Didesmethyl cariprazine
|
|
Dopamine Receptor
,
5-HT Receptor
|
|
Didesmethyl cariprazine, a metabolite of Cariprazine, is the major cyclic active part. Didesmethyl cariprazine has a long half-life of 1-3 weeks. Cariprazine is a potent D3 preference D3/D2 receptor partial agonist of do... |
|
T19680 |
Zotepine
|
|
Dopamine Receptor
,
5-HT Receptor
,
Adrenergic Receptor
,
Histamine Receptor
|
|
Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic, and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM, and 8 nM, respectively. Zotepine is a second... |
|
T22589 |
Asenapine hydrochloride
|
|
Others
|
|
Asenapine is a new atypical antipsychotic developed for the treatment of schizophrenia and acute mania associated with bipolar disorder. |
|
T63592 |
Thiothixene hydrochloride
|
|
|
|
Thiothixene hydrochloride is an antipsychotic agent that can be used in the study of schizophrenia and bipolar mania. |
|
T28282 |
Oxypertine
|
Win-18501,Forit,Win18501,Win 18501 |
|
|
Oxypertine is an indole-derivative antipsychotic with general properties similar to those of the chlorpromazine and phenothiazine. Oxypertine is used as a treatment for various psychoses including mania, schizophrenia, ... |
|
T71578 |
Endoxifen mesylate
|
|
|
|
Endoxifen, also known as N-desmethyl-4-hydroxytamoxifen, is a chemical that is under development for estrogen receptor-positive breast cancer. It is also being evaluated as an antipsychotic for treatment of mania and ot... |
|
T9540 |
Phenelzine
|
Fenelzyna,(2-phenylethyl)-hydrazin |
Dopamine Receptor
,
Serotonin Transporter
,
Norepinephrine
|
|
Phenelzine is an antidepressant and mania drug, which is a monoamine oxidase inhibitor. Its antidepressant effect is similar to that of niacinamide. It can reduce the degradation of catecholamines (norepinephrine, dopami... |
