Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic, and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM, and 8 nM, respectively. Zotepine is a second-generation antipsychotic with a primary use as a treatment for schizophrenia, although clinical trials have been conducted into its efficacy as an antimanic agent in patients with acute bipolar mania.
説明 | Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic, and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM, and 8 nM, respectively. Zotepine is a second-generation antipsychotic with a primary use as a treatment for schizophrenia, although clinical trials have been conducted into its efficacy as an antimanic agent in patients with acute bipolar mania. |
ターゲット&IC50 | 5-HT2C:3.2 nM(Kd), 5-HT2A:2.6 nM(Kd), H1 receptor:3.3 nM(Kd) |
分子量 | 331.86 |
分子式 | C18H18ClNOS |
CAS No. | 26615-21-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (75.33 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Zotepine 26615-21-4 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor 5-HT Receptor Adrenergic Receptor Dopamine Receptor antipsychotic antidepressive Serotonin Receptor Inhibitor anxiolytic inhibit 5-hydroxytryptamine Receptor Beta Receptor inhibitor