83
1
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T8485 | THIQ | Melanocortin Receptor | |
THIQ is a selective melanocortin-4 receptor (MC4R) agonist (hMC4R and rMC4R with IC50 of 1.2 nM and 0.6 nM , respectively). | |||
TP1898 | HS024 | HS 024 | Melanocortin Receptor |
HS024 is a highly potent melanocortin MC4 receptor antagonist (Ki values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake, and blocks α-MSH- and MTII-... | |||
T7589 | Afamelanotide acetate | afamelanotide | Melanocortin Receptor |
Afamelanotide acetate is a synthetic α-melanocyte stimulating hormone analogue and first-in-class melanocortin-1 receptor agonist, used to for Erythropoietic Protoporphyria. | |||
TP1889 | MCL0020 | MCL 0020 | Melanocortin Receptor |
MCL0020 is a potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and > 10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no e... | |||
T5464 | JNJ-10229570 | JNJ10229570,UNII-N9IX402L35,JNJ 10229570 | Melanocortin Receptor |
JNJ-10229570 (UNII-N9IX402L35) is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R), which inhibits sebaceous gland differentiation and the production of sebum-specific lipids. | |||
T7608 | Bremelanotide Acetate | bremelanotide,PT-141 Acetate | Melanocortin Receptor |
Bremelanotide Acetate (PT-141 Acetate) is an agonist of melanocortin receptor (MCR) . | |||
T7813 | α-MSH | MSH, amide,CZEN-002,α-Melanocyte-Stimulating Hormone (MSH), amide | Melanocortin Receptor , Adenylyl cyclase |
α-MSH (MSH, amide) is amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase. | |||
TP1097 | Melanotan I | [Nle4,D-Phe7]-α-MSH,Afamelanotide,MT-I | Others |
Melanotan I is a non-specific melanocortin receptor (MCR) agonist, an α-melanocyte-stimulating hormone (α-MSH) analog, which is injected subcutaneously to increase the amount of melanin in the skin Melanotan I is used as... | |||
T7769 | Nonapeptide-1 | Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-,Melanostatine™ 5 | Others |
Nonapeptide-1 (Melanostatine™ 5) can inhibit the synthesis of melanin, which makes it of interest for treating certain skin conditions. | |||
T7627 | Adrenocorticotropic Hormone (ACTH) (4-10), human | Adrenocorticotropic Hormone (ACTH) (4-10),ACTH (4-10), human,Acth (4-10) | Melanocortin Receptor |
Adrenocorticotropic Hormone (ACTH) (4-10) is an agonist of potent melanocortin(MC4R) receptor . | |||
T9596 | AP1189 acetate | Melanocortin Receptor | |
AP1189 acetate is a biased agonist at melanocortin 1 and melanocortin 3 receptors. | |||
TP1953L | PG 931 acetate | PG 931 acetate (667430-81-1 Free base) | Melanin-concentrating Hormone Receptor (MCHR) |
PG 931 acetate is a potent agonist of melanocortin 4 (MC4) receptors. | |||
T8231 | Adrenocorticotropic Hormone (ACTH) (1-39), human | ACTH (1-39), human | Others |
Adrenocorticotropic Hormone (ACTH) (1-39), human (ACTH (1-39), human) is an agonist of melanocortin receptor. | |||
T23516 | VU590 | Potassium Channel | |
VU590 is a potent and moderately selective inhibitor of extrarenal medullary potassium ROMK (Kir1.1).VU590 inhibits Kir7.1 and modulates uterine myometrial contractility and melanocortin signalling. | |||
T7627L | Adrenocorticotropic Hormone (ACTH) (4-10) TFA | Adrenocorticotropic Hormone (ACTH) (4-10) TFA(4037-01-8(free base)),Acth (4-10) | Melanocortin Receptor |
Adrenocorticotropic Hormone (ACTH) (4-10) TFA (Acth (4-10)) is an agonist of potent melanocortin(MC4R) receptor . | |||
TP1011L | ACTH (1-17) acetate | Melanocortin Receptor | |
ACTH (1-17) acetate is a potent agonist at the human melanocortin 1 (MC1) receptor with high affinity(Ki = 0.21 nM). | |||
T69526 | PF-07258669 | Melanocortin Receptor | |
PF-07258669 is a selective melanocortin 4 receptor (MC4) antagonist used in the study of cachexia and loss of appetite. | |||
TP1004L | Beta-MSH (1-22) (human) acetate | Beta-MSH (1-22) (human) acetate (17908-57-5 Free base) | Melanocortin Receptor |
Beta-MSH (1-22) (human) acetate (Beta-MSH (1-22) (human) acetate (17908-57-5 Free base)) , is an endogenous melanocortin-4 receptor (MC4-R) agonist. | |||
TP1324 | Melanotan (MT)-II | Melanocortin Receptor | |
Melanotan (MT)-II, a synthetic melanocortin receptor agonist, is a synthetic analogue of the peptide hormone α-melanocyte-stimulating hormone (α-MSH). | |||
T12882L | Setmelanotide Acetate(920014-72-8 free base) | RM-493 Acetate,IRC-022493 Acetate,BIM-22493 Acetate | Melanocortin Receptor |
Setmelanotide Acetate(920014-72-8 free base) (RM-493 Acetate) is a selective agonist of melanocortin 4 receptor (MC4R)(human and rat MC4R with EC50s of 0.27 nM and 0.28 nM, respectively). | |||
TP2212L | A-MSH, amide Acetate(581-05-5 free base) | Melanocortin Receptor | |
a-MSH, amide Acetate as an endogenous neuropeptide. It is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic activities. α-MSH is a post-translational derivative of pro-opiomelano... | |||
TP1893L1 | [D-Trp8]-γ-MSH acetate(321351-81-9 free base) | Melanocortin Receptor | |
[D-Trp8]-γ-MSH acetate(321351-81-9 free base) is a selective melanocortin 3 (MC3) receptor agonist (IC50 values are 6.7, 340 and 600 nM for human MC3, MC5 and MC4 receptors respectively) and displays anti-inflammatory ef... | |||
T16879L | SHU 9119 acetate | SHU 9119 acetate (168482-23-3 free base) | Melanocortin Receptor |
SHU 9119 acetate is a well-known antagonist of human melanocortin 3 and 4 (hMC3R, hMC4R) receptors and a partial hMC5R agonist. The IC50 values of human MC3R, MC4R and MC5R is 0.23, 0.06, and 0.09 nM respectively. | |||
TP1952L | PG 106 acetate | PG 106 acetate(944111-22-2 Free base) | Melanocortin Receptor |
PG 106 acetate is an effective and selective antagonist of the human melanocortin 3 (hMC3) receptor with an IC50 of 210 nM. PG 106 acetate has no activity with the hMC5 receptor and hMC4 receptors with an EC50 of 9900 nM... | |||
TP2015L | HS 014 acetate(207678-81-7 free base) | Melanocortin Receptor | |
HS 014 acetate is a potent and selective melanocortin MC4 receptor antagonist (Ki values are 3.16, 108, 54.4 and 694 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake in rats and no... | |||
T25310 | Dersimelagon | MT-7117 | Melanocortin Receptor |
Dersimelagon (MT-7117) is an orally active, selective agonist for the melanocortin 1 receptor (MC1R), demonstrating EC50 values of 8.16 nM (h), 3.91 nM (cm), 1.14 nM (m), and 0.251 nM (r) across species such as human, cy... | |||
T22989 | ML 00253764 hydrochloride | Others | |
melanocortin MC4 receptor antagonist | |||
TP1242 | 1-39-Corticotropin (human)(TFA) | Adrenocorticotropic Hormone (ACTH) (1-39), human(TFA) | |
Adrenocorticotropic Hormone (ACTH) (1-39) human(TFA),a member of the melanocortin family, is a melanocortin receptor agonist. It stimulates production of CS by the adrenals, but melanocortin receptors are also found in t... | |||
T33419 | MK-0493 HCl | MK 0493,MK-0493,MK0493 | |
MK-0493 is a novel, potent, and selective agonist for melanocortin receptor 4 (MC4R). | |||
T24495 | MPCI | ||
MPCI is a selective melanocortin-4 receptor antagonist. | |||
T28635 | RY764 | RY 764,RY-764 | |
RY764 is a potent and selective agonist of melanocortin subtype-4 receptor. | |||
T12415 | PF-00446687 | Others | |
PF-00446687 is a selective agonist of melanocortin-4 receptor (MC4R) (EC50 of 12 ± 1 nM). | |||
T27986 | MCL0129 | MCL-0129,MCL 0129 | |
MCL0129, a selective and non-peptidergic melanocortin 4 (MC4) receptor antagonist, is a potential treatment for cachexia. | |||
T10251 | Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA | ACTH (1-39) (mouse, rat) TFA | Others |
Adrenocorticotropic Hormone (ACTH) (1-39), rat (TFA) is a potent melanocortin 2 receptor (MC2) agonist. | |||
T16086 | MK-0493 | Others | |
MK-0493 is an effective and selective agonist of the melanocortin receptor 4 (MC4R). It also demonstrated significant reductions in energy intake. | |||
T10230 | MC-4R Agonist 1 | Others | |
MC-4R Agonist 1 is an agonist of human melanocortin-4 receptor (MC-4R) and can be used in the research of sexual dysfunction, obesity, and diabetes. | |||
T12072 | ML-00253764 hydrochloride | Others | |
ML-00253764 hydrochloride is an antagonist of nonpeptidic melanocortin receptor 4 (MC4R) (Ki and IC50 of 0.16 µM and 0.103 µM, respectively). | |||
T69607 | Dersimelagon phosphate | ||
Dersimelagon phosphate is a selective melanocortin-1 receptor (MC1R) agonist that increases skin melanin without sun exposure and is being developed to increase light tolerance in EPP/XLP patients. | |||
T12944 | SNT-207707 | Others | |
SNT-207707 is a potent, selective and orally active antagonist of melanocortin MC-4 receptor(IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor). | |||
T75965 | β-Melanocyte Stimulating Hormone (MSH), human TFA | ||
β-Melanocyte Stimulating Hormone (MSH), human TFA, is a 22-residue peptide that functions as an endogenous agonist for the melanocortin-4 receptor (MC4-R) [1]. | |||
T16879 | SHU 9119 | Others | |
SHU 9119 is an effective human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist (IC50: 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively). | |||
T20467 | Bremelanotide | PT-141,PT141,PT 141 | |
Bremelanotide is a synthetic peptide analog of alpha-MSH and is an agonist at melanocortin receptors including the MC3R and MC4R. | |||
TP1004 | β-Melanocyte Stimulating Hormone (MSH), human | Beta-MSH (1-22) (human) | |
Stimulating -Melanocyte Stimulating Hormone (MSH), human TFA, is a 22 peptide and is an endogenous melanocortin-4 receptor.MC4 - R) agonists. | |||
T12945 | SNT-207858 free base | Others | |
TP1893 | [D-Trp8]-γ-MSH | ||
[D-Trp8]-γ-MSH is a selective melanocortin 3 (MC3) receptor agonist (IC50 values are 6.7, 340 and 600 nM for human MC3, MC5 and MC4 receptors respectively). [D-Trp8]-γ-MSH displays anti-inflammatory efficacy. | |||
T75977 | ACTH (1-17) (TFA) | ||
ACTH (1-17) TFA, an analogue of adrenocorticotropin, serves as a highly effective agonist for the human melanocortin 1 (MC1) receptor, exhibiting a dissociation constant (K i) of 0.21 nM. | |||
T68328 | Modimelanotide | ||
Modimelanotide is a melanocortinergic peptide drug derived from α-melanocyte-stimulating hormone (α-MSH) which was under development for the treatment of acute kidney injury. It acts as a non-selective melanocortin recep... | |||
TP1010 | ACTH (1-17) (TFA) (7266-47-9 free base) | α1-17-ACTH TFA,ACTH (1-17) (TFA) | |
ACTH (1-17) TFA is a corticotrophin analogue and an effective human melanocortin 1 (MC1) receptor agonist with Ki value of 0.21 nM. | |||
T10568 | BMS-470539 dihydrochloride | Others | |
T12946 | SNT-207858 | Others | |
カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPY-01117 | MRAP Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
MRAP (Melanocortin 2 Receptor Accessory Protein) is a Protein Coding gene. This gene encodes a melanocortin receptor-interacting protein. It belongs to the MRAP family. MRAP, which contains a single transmembrane domain,... |