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T3280 |
Clodronate disodium tetrahydrate
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clodronic acid disodium tetrahydrate,Disodium clodronate tetrahydrate,Clastoban,Clodronate disodium |
IL Receptor
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TNF
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Clodronate disodium tetrahydrate (Clastoban) inhibits bone resorption and soft tissue calcification. |
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T7881 |
CTP disodium dihydrate
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P2X Receptor
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CTP disodium dihydrate is an agonist of P2X4 purinergic receptor |
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T4298 |
JNJ-47965567
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JNJ-479655 |
P2X Receptor
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JNJ-47965567 (JNJ-479655) is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel(with pKis of 7.9 and 8.7 for human and rat P2X7, respectively). |
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T23164 |
PIT
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2,2'-Pyridylisatogen tosylate |
P2Y Receptor
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PIT (2,2'-Pyridylisatogen tosylate) is a specific and non-competitive antagonist of the Purinergic receptor P2Y1 with an IC50 of 0.14 μM for human P2Y1. PIT does not affect nucleotide binding and can be used in studies a... |
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T8946 |
Indophagolin
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P2X Receptor
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5-HT Receptor
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Autophagy
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Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. |
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T20731 |
Brilliant blue G-250
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BBG,Acid blue 90, Coomassie Brilliant Blue G,Brilliant Blue G |
P2X Receptor
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Brilliant blue G-250 (Acid blue 90, Coomassie Brilliant Blue G) is an antagonist of the P2X7 purinergic receptor. |
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T19049 |
Procion Blue HB
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Reactive Blue 2 |
Others
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Procion Blue HB is an antagonist of purinergic. |
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T23241 |
Ro 0437626
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Others
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P2X1 purinergic receptor antagonist |
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T23581 |
2-Methylthioadenosine diphosphate trisodium
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2 Methylthio ADP,2MeSADP,2-Methylthio-ADP,2 MeS ADP,2-MeS-ADP |
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2-MeS-ADP is a purinergic agonist that acts by displaying selectivity for P2Y1, P2Y12, and P2Y13 receptors and inhibiting cAMP accumulation. |
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T70667 |
KF 20274
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KF 20274 is an adenosine A1 antagonist; purinergic receptor antagonist. |
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T70450 |
BMS-870145
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BMS-870145 is a potent and selective P2Y1 purinergic receptor antagonist.. |
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T62488 |
P2X7 receptor antagonist-1
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P2X7 receptor antagonist-1 is a purinergic P2X7 receptor antagonist with anti-neuroinflammatory effects. |
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T29730 |
AGR-540
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AGR540 |
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AGR-540 is a prodrug of AGR-529. AGR-540 has been shown to return plasma triglyceride concentrations to normal levels in mouse models. This effect may be attributed to an interaction of the molecule with A1 purinergic re... |
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T39891 |
8-Bromo-ATP
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8-Bromoadenosine 5'-triphosphate,8-Bromo-ATP,8-Br-ATP |
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8-Bromo-ATP (8-Bromoadenosine 5'-triphosphate) is a purinergic P2X receptor agonist and an ATP analogue. It exhibits cytotoxicity towards multiple myeloma cells, with an IC50 of 23.1 μM. |
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T74409 |
EVT-401
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EVT-401 (P2X7 receptor antagonist-1), a purinergic P2X7 receptor antagonist, demonstrates efficacy in combating neuroinflammation [1]. |
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T83823 |
Sp-Uridine-5'-O-(1-thiotriphosphate) sodium
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Sp-UTP-α-S |
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Sp-Uridine-5'-O-(1-thiotriphosphate) (Sp-UTP-α-S) acts as a nucleotide agonist for purinergic Y2 (P2Y2) and P2Y4 receptors, efficiently inducing inositol phosphate accumulation in 1321N1 astrocytoma cells that express th... |
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T83839 |
Uridine 5'-methylenediphosphate sodium
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α,β-methylene UDP,UMP-CP |
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Uridine 5’-methylenediphosphate (UMP-CP), a hydrolytically stable derivative of UDP and agonist of the purinergic P2Y14 receptor, exhibits selective inhibition of cAMP production in cells expressing human P2Y14 compared ... |
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T36222 |
2-oxo Clopidogrel
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2-oxo Clopidogrel is an intermediary metabolite of clopidogrel . Clopidogrel is a prodrug that is converted to its active metabolite via two sequential oxidative steps. The first step leads to formation of 2-oxo clopidog... |
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T35431 |
(±)-Clopidogrel (hydrochloride)
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Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM). Clopidogrel inhibits ADP-induced platelet aggregation ex ... |
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T83822 |
Rp-Uridine-5'-O-(1-thiotriphosphate) sodium
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Rp-UTP-α-S |
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Rp-Uridine-5'-O-(1-thiotriphosphate) (Rp-UTP-α-S) serves as a nucleotide agonist for purinergic P2Y2 and P2Y4 receptors, effectively inducing inositol phosphate accumulation within 1321N1 astrocytoma cells that express e... |
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T83827 |
Adenosine-5'-O-(3-thiotriphosphate) sodium
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ATPγS,Adenosine 5'-(γ-thio)-triphosphate |
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Adenosine-5'-O-(3-thiotriphosphate) (ATPγS), an agonist of the purinergic P2Y11 receptor, prompts inositol phosphate accumulation in CHO-K1 cells harboring the human or canine P2Y11 receptor with EC50 values of 1.2 and 1... |
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T33631 |
Neocuproine
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Neocuproin |
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Neocuproine is a copper(I) chelator that enhances the purinergic component of vasoconstriction induced by electric field stimulation, and is often used as a ligand reagent and copper ion detector.Neocuproine forms stable... |
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T37313 |
ITH15004
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ITH15004 is a non-nucleotide antagonist of the purinergic P2X7receptor (IC50= 9 μM in HEK293 cells expressing the human receptor).1It inhibits ATP-induced currents inX. laevisoocytes expressing the human P2X7receptor whe... |
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T83833 |
Rp-2'-Deoxyuridine-5'-O-(1-thiotriphosphate) sodium
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Rp-dUTP-α-S |
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Rp-2'-Deoxyuridine-5'-O-(1-thiotriphosphate) (Rp-dUTP-α-S), a sulfur-containing nucleotide isomer and purinergic P2Y2 receptor agonist, preferentially promotes inositol phosphate accumulation in 1321N1 astrocytoma cells ... |
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T36112 |
Clopidogrel Carboxylic Acid (hydrochloride)
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Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM). Clopidogrel inhibits ADP-induced platelet aggregation ex ... |
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T83803 |
UDP-β-S sodium
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Uridine-5' O-(2-thiodiphosphate) |
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UDP-β-S, serving as a specific agonist for the purinergic P2Y6 receptor, effectively promotes inositol phosphate accumulation in 1321N1 cells containing P2Y6 receptors, with an EC50 value of 28 nM. This selectivity is ev... |
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T83813 |
8-Azidoadenosine-5'-O-diphosphate sodium
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8-azido-ADP,Click Tag™ 8-Azidoadenosine-5'-O-diphosphate |
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8-Azidoadenosine-5'-O-diphosphate (8-azido-ADP), a clickable variant of the ATP precursor and purinergic receptor ligand ADP, serves as a photoaffinity label for proteins including glutamate dehydrogenase (GDH) isoprotei... |
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T83840 |
Uridine-5'-O-(3-thiotriphosphate) sodium
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UTP-γ-S |
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Uridine-5'-O-(3-thiotriphosphate) (UTP-γ-S) is a hydrolysis-resistant UTP derivative and an agonist of the purinergic P2Y2 receptor. It effectively induces inositol phosphate formation in 1321N1 astrocytoma cells harbori... |
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T83808 |
Sp-Adenosine-5'-O-(1-thiotriphosphate) sodium
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Sp-ATP-α-S |
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Sp-Adenosine-5'-O-(1-thiotriphosphate) (Sp-ATP-α-S), an isomer of the ATP-α-S sulfur-containing nucleotide derivative and a purinergic P2Y1 receptor agonist, effectively increases calcium mobilization in HEK293 cells har... |
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T83807 |
Rp-Adenosine-5'-O-(1-thiotriphosphate) sodium
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Rp-ATP-α-S |
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Rp-Adenosine-5'-O-(1-thiotriphosphate) (Rp-ATP-α-S), a sulfur-containing nucleotide derivative isomer and a purinergic P2Y1 receptor agonist, promotes calcium mobilization in HEK293 cells expressing the human P2Y1 recept... |
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T83802 |
TNP-ATP sodium
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TNP-ATP, a derivative of ATP, acts as an antagonist to the purinergic P2Y1, P2X3, and P2X2/3 receptors, demonstrating selectivity by showing lower inhibitory concentrations (IC50 = 6, 0.9, 7 nM, respectively) compared to... |
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T83820 |
TNP-GTP sodium
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TNP-Guanosine 5'-triphosphate |
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TNP-GTP, a fluorescent derivative of guanosine 5'-triphosphate (GTP), essential for protein synthesis and gluconeogenesis, exhibits an emission peak at 552 nm when excited at 410 nm in water. Its fluorescence intensity i... |
